Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

500 SMALLPOX VACCINE
Exanthems
(2004): Greenberg RN+, Clin Infect Dis 38(7), 958
Exfoliative dermatitis
Folliculitis
(2005): Oh RC, Mil Med 170(2), 133 (2 cases)
(2004): Greenberg RN+, Clin Infect Dis 38(7), 958
Herpes simplex
(1982): Mintz L, JAMA 247(19), 2704 (recurrent) (at site)
Herpes zoster
Histiocytoma
(1981): Slater DN+, Br J Dermatol 105(2), 215
Jadassohn–Borst epithelioma
Kaposi’s varicelliform eruption
Keratoacanthoma
Lichen vaccinatus
Lupus erythematosus (discoid)
(1987): Lupton GP, JAmAcadDermatol17, 688 (in vaccination
scar)
Melanoma
Photosensitivity
Pigmentation
Pruritus
(2004): Greenberg RN+, Clin Infect Dis 38(7), 958
Purpura
(1981): Burke PJ+, Pa Med 84(9), 49
Pyogenic granuloma
Rash (sic)
(2002): Frey SE+, NEnglJMed346, 1265 (site other than
vaccination site)
Scar
(2006): Waibel KH+, Int J Dermatol 45(6), 764 (exaggerated)
Side effects (sic) (0.01%)
Stevens–Johnson syndrome
(2004): Chopra A+, Mayo Clin Proc 79(9), 1193
(2003): Wharton M+, MMWR Recomm Rep 52(RR-7), 1
Toxic epidermal necrolysis
Urticaria
(2004): Greenberg RN+, Clin Infect Dis 38(7), 958
Vaccinia
(2004): Kelly CD+, J Clin Microbiol 42(3), 1373
(2003): Miller JR+, Emerg Infect Dis 9(12), 1649
(2003): Wharton M+, MMWR Recomm Rep 52(RR-7), 1
(1988): Landthaler M+, Hautarzt 39, 322
(1980): Kanra G+, Cutis 26, 267 (vulva from 7–month-old
daughter’s vaccination)
Vaccinia gangrenosum
Vaccinia necrosum
(1982): MMWR Morb Mortality Wkly Rep 31(36), 501
(1981): Funk EA+, South Med J 74(3), 383
Eyes
Blepharitis
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Conjunctivitis
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Corneal opacity
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Eyelid pruritus
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Iritis
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Keratouveitis
(1994): Lee SF+, Am J Ophthalmol 117(4), 480 (autoinoculation)
Periorbital edema
(2004): Fillmore GL+, Ophthalmology 111(11), 2086
Photophobia
(2005): McMahon AW+, Vaccine 2005 Jan 19;23(9), 1097
Other
Chills
(2002): Frey SE+, NEnglJMed346, 1265
Death
(2006): Kretzschmar M+, PLoS Med 3(8), e272
(2003): MMWR Morb Mortal Wkly Rep 52(39), 933 (2 cases)
Fever
Injection-site pain
(2002): Frey SE+, NEnglJMed346, 1265
Injection-site pyoderma
(2003): Wharton M+, MMWR Recomm Rep 52(RR-7), 1
Myalgia/Myositis/Myopathy/Myotoxicity
(2002): Frey SE+, NEnglJMed346, 1265
Tumors
SODIUM CROMOGLYCATE
(See CROMOLYN)
SODIUM OXYBATE
Synonyms: Gamma Hydroxybutyrate; GHB
Trade name: Xyrem (Orphan Medical)
Indications: Cataplexy (in patients with narcolepsy)
Category: Anesthetic, general
Half-life: 0.3–1 hour
Clinically important, potentially hazardous interactions
with: alcohol, hypnotics, sedatives
Reactions
Skin
Diaphoresis
(2001): Bowles TM+, Pharmacotherapy 21(2), 254 (following
withdrawal)
(2001): Dyer JE+, Ann Emerg Med 37(2), 147 (following
withdrawal)
(2000): Craig K+, JEmergMed18(1), 65 (following withdrawal)
Mucosal
Sialorrhea
Other
Death
(2002): Smith KM+, Am J Health Syst Pharm 59(11), 1067
(2001): Dyer JE+, Ann Emerg Med 37(2), 147 (following
withdrawal)
(2001): Kalasinsky KS+, JForensicSci46(3), 728
(2001): Nini A+, Harefuah 140(12), 1148
(2001): Okun MS+, J Pharm Pharm Sci 4(2), 167
(2001): Persson SA+, Lakartidningen 98(38), 4026
(2000): Timby N+, Am J Med 108(6), 518
(1998): Li J+, Ann Emerg Med 31(6), 729
(1995): Ferrara SD+, JForensicSci40(3), 501 (also taking IV
heroin)
Infections
Pain
Porphyria
Rhabdomyolysis
Upper respiratory infection
Note: Sodium oxybate is a class of drugs that are also known as:
‘Designer’ drugs; Party drugs; Club drugs; Recreational drugs; ‘Rave’
drugs; Fantasy drugs; Date rape drugs; abuse drugs