Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

SELENIUM
Trade names: Bio-Active Selenium (Solaray); Exsel Shampoo;
Head & Shoulders Intensive Treatment Dandruff Shampoo
(Procter & Gamble); Selenate; Selenite; selenium dioxide;
selenium sulfide; selenocysteine; SelenoMax (Source Naturals);
selenomethionine; Selsun Blue (Chattem); Selsun Shampoo
(Chattem); Vpak51
Indications: Anticancer (stomach, colorectal, lung, prostate),
arthritis, asthma, heart disease, HIV inhibitor. Treatment of
dandruff, fungal infections (tinea versicolor), and seborrhea
Category: Antioxidant; Trace element
Half-life: 12–41 hours; Selenomethionine: 252 days, Selinite: 102
days
Clinically important, potentially hazardous interactions
with: cholesterol-lowering drugs, cisplatin, clozapine,
dimercaprol, niacin, oral corticosteroids, simvastatin
Reactions
Skin
Adverse effects (sic)
(1994): Yang G+, J Trace Elem Electrolytes Health Dis 8(3–4), 159
(chronic exposure)
(1989): Stacchini A+, J Trace Elem Electrolytes Health Dis
3(4), 193
Allergic reactions (sic)
Carcinoma
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic
exposure)
(2000): Vinceti M+, J Clin Epidemiol 53(10), 1062 (chronic
exposure)
(2000): Vinceti M+, Sci Total Environ 250(1–3), 1 (chronic
exposure)
(1999): Barceloux DG, J Toxicol Clin Toxicol 37(2), 145
(deficiency)
(1997): Foster LH+, Crit Rev Food Sci Nutr 37(3), 211
(deficiency)
Dermatitis
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic
exposure)
Diaphoresis
Erythema chronicum persistans
(2003): Smith S, Louisville, KY (from Internet) (observation)
Lupus erythematosus (from deficiency)
Melanoma
(1998): Vinceti M+, Cancer Epidemiol Biomarkers Prev 7(10), 853
(chronic exposure)
Photosensitivity
Pruritus
Rash (sic)
Scleroderma (deficiency)
Mucosal
Sialorrhea
Hair
Hair – alopecia
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic
exposure)
(1996): Whanger P+, Ann Clin Lab Sci 26(2), 99 (chronic
exposure)
Hair – brittle
(1994): Yang G+, J Trace Elem Electrolytes Health Dis 8(3–4), 159
(chronic exposure)
Hair – changes (sic)
(1999): Barceloux DG, J Toxicol Clin Toxicol 37(2), 145 (chronic
exposure)
(1997): Hathcock JN, Am J Clinical Nutrition 66, 427
Hair – pigmentation
Nails
Nails – brittle
(1997): Hathcock JN, Am J Clinical Nutrition 66, 427
(1996): Whanger P+, Ann Clin Lab Sci 26(2), 99 (chronic
exposure)
(1995): Yang GQ+, Biomed Environ Sci 8(3), 187 (deficiency)
(1994): Yang G+, J Trace Elem Electrolytes Health Dis 8(3–4), 159
(chronic exposure)
Nails – loss
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic
exposure)
Nails – paronychia
Nails – white streaking
Other
Death (overdose)
Infections
Myalgia/Myositis/Myopathy/Myotoxicity
Note: Selenium is an essential component of glutathione peroxidase.
Inadequate concentrations of dietry selenium account, in part, for
Keshan disease (a fatal cardiomyopathy)
SENNA
Scientific names: Cassia acutifolia; Cassia angustifolia; Cassia
obtusifloia; Cassia senna; Cassia tora; Senna alexandrina; Senna
obtusifolia; Senna tora
Family: Caesalpiniaceae; Fabaceae
Trade and other common names: Agiolax; Agoral (Numark);
Alesandrian; Black-Draught (Monticello); Cassia leaf; Ex-Lax
(Novartis); Fletcher’s Castoria (Mentholatum); Gentlax ;
Glysennid; Goldline Senna; Herbal Trim Tea; Khartoum senna;
Laci Le Beau Corp; Manevac; Perdiem (Novartis); PMS-
Sennosides; Prodiem Plus (Novartis); Riva-Senna; Senexon; Senna
alenxandrina; Senna Lax; Senna-Gen; Sennatab; Senokot; Senolax;
Super Dieter’s Tea; X-Prep
Category: Stimulant laxative
Purported indications and other uses: Laxative, cathartic,
cholagogue, purgative
Half-life: N/A
Clinically important, potentially hazardous interactions
with: digoxin, quinidine, squill
Part used: Leaves and/or seed pods
Reactions
SENNA 493
Skin
Acute generalized exanthematous pustulosis (AGEP)
(2003): Bonnetblanc JM+, Ann Dermatol Venereol 130(1 Pt 1), 59
Adverse effects (sic)
(1996): Sykes NP, JPainSymptomManage11(6), 363
(1993): Passmore AP+, Pharmacology 47, 249
(1988): Jagjivan B+, Br J Radiol 61(729), 853
Allergic reactions (sic)
(1991): Marks GB+, Am Rev Respir Dis 144(5), 1065
Bullous dermatitis
(2003): Spiller HA+, Ann Pharmacother 37(5), 636
Dermatitis
(2001): Leventhal JM+, Pediatrics 107(1), 178
Edema