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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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490 SACCHARIN<br />

(1989): Birbeck J, NZMedJ102, 24<br />

*Note: Saccharin is a sulfonamide <strong>and</strong> can be absorbed systemically.<br />

Sulfonamides can produce severe, possibly fatal, reactions such as<br />

toxic epidermal necrolysis <strong>and</strong> Stevens–Johnson syndrome<br />

SALMETEROL<br />

Trade names: Advair (GSK); Salmeter; Serevent (GSK); Serobid;<br />

Zantirel<br />

Indications: Asthma<br />

Category: Adrenergic beta2-receptor agonist<br />

Half-life: 3–4 hours<br />

Reactions<br />

Skin<br />

Angioedema<br />

Eczema<br />

(1997): Leal GB, Fortaleza, Brazil (from Internet) (observation)<br />

Exanthems<br />

Pruritus<br />

Rash (sic) (1–3%)<br />

(1994): D’Alonzo GE+, JAMA 271, 1412<br />

(1991): Hatton MQ+, Lancet 337, 1169<br />

Urticaria (1–3%)<br />

(1991): Hatton MQF+, Lancet 337, 1169<br />

Mucosal<br />

Oral c<strong>and</strong>idiasis<br />

(2002): Beeh KM+, Pneumologie 56(2), 91<br />

Other<br />

Death<br />

(2006): Currie GP+, <strong>Drug</strong> Saf 29(8), 647<br />

(2006): Dekhuijzen PN, Ned Tijdschr Geneeskd 150(16), 889<br />

(2006): Donohue JF+, J Fam Pract Suppl, 1<br />

(2006): Lang DM, Cleve Clin J Med 73(11), 973<br />

(2006): Martinez FD, Clin Rev Allergy Immunol 31(2–3), 269<br />

(2006): Salpeter SR+, AnnInternMed144(12), 904<br />

(2003): Prescrire Int 12(66), 142<br />

Hypersensitivity (

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