Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

(1995): Brandstatter G+, Clin Ther 17(3), 467
(1988): Inoue M, Drugs 35, 114
Other
Myalgia/Myositis/Myopathy/Myotoxicity
ROXITHROMYCIN
Trade names: Biaxsig (Aventis); Romicin (Pacific); Ruclid; Rulid
(Roussel-Uclaf); Ruxid; Surlid
Indications: Respiratory tract, urinary and soft tissue infections
Category: Antibiotic, macrolide
Half-life: 8–15 hours
Clinically important, potentially hazardous interactions
with: digoxin, disopyramide, ergot alkaloids, gemfibrozil,
midazolam, simvastatin, terfenadine, theophylline, warfarin
Reactions
Skin
Allergic granulomatous angiitis (Churg–Strauss syndrome)
(1998): Dietz A+, Laryngorhinootologie 77(2), 111
Angioedema
Baboon syndrome
(2002): Amichai B+, Clin Exp Dermatol 27(6), 523
Erythema
(2001): Easton-Carter KL+, Pharmacotherapy 21(7), 867
Fixed eruption
(1998): Kruppa A+, Dermatology 196(3), 335
Pruritus
Purpura
Rash (sic)
(2001): Easton-Carter KL+, Pharmacotherapy 21(7), 867
(1995): Durant J+, Infection 23 Suppl 1, S33
Urticaria
(2002): Gurvinder SK+, Allergy 57(3), 262
(1998): Kruppa A+, Dermatology 196(3), 335
Nails
Nails – onycholysis
(2005): Sharma N+, Indian J Dermatol Venereol Leprol 71, 49
Nails – pigmentation
(1995): Dawn G+, Dermatology 191(4), 342
Other
Abdominal pain
(1998): Sprinz E+, J Antimicrob Chemother 41 Suppl B, 85
(1995): Durant J+, Infection 23 Suppl 1, S33
Adverse effects
(2004): Akcay A+, Ann Pharmacother 38(4), 721
(2000): Hatipoglu ON+, Yonsei Med J 41(3), 340 (6.6%)
(1998): Moniot-Ville N+, JIntMedRes26(3), 144
(1998): Tatsis G+, J Antimicrob Chemother 41 Suppl B, 69 (3%)
(1994): Markham A+, Drugs 48(2), 297 (4%)
(1992): De Vlieger A+, Diagn Microbiol Infect Dis 15(4
Suppl), 123S
(1992): Marsac JH, Diagn Microbiol Infect Dis 15(4 Suppl), 81S
(4%)
Hypersensitivity
(1998): Kruppa A+, Dermatology 196(3), 335
Infections
(2002): Perez-Castrillon JL+, Ann Pharmacother 36(11), 1808
RUE
Scientific names: Ruta chalepensis; Ruta corsica; Ruta graveolens;
Ruta montana
Family: Rutaceae
Trade and other common names: Country man’s treacle;
Herb of grace; Herbygrass; ruda
Category: Antispasmodic
Purported indications and other uses: Hysteria, coughs,
croup, colic, flatulence, mild stomachic, insomnia, abdominal
cramps, nervous headache, giddiness, hysteria, palpitation,
abortifacient, cysticide, vermifuge, insecticide. Topical: irritant,
rubefacient for eczemas, psoriasis and rheumatic pain, sciatica,
headache, chronic bronchitis. Flavoring in alcoholic beverages,
salads, meats and cheeses
Half-life: N/A
Reactions
Skin
Bullous dermatitis
(1999): Schempp CM+, Hautarzt 50(6), 432
Clammy skin
Dermatitis
Edema
Erythema
(1985): Brener S+, Contact Dermatitis 12(4), 230
(1983): Heskel NS+, Contact Dermatitis 9(4), 278
Photosensitivity
(1999): Schempp CM+, Hautarzt 50(6), 432
(1999): Wessner D+, Contact Dermatitis 41(4), 232
(1995): Ortiz-Frutos FJ+, Contact Dermatitis 33(4), 284
(1990): Ena P+, Contact Dermatitis 22(1), 63
(1989): Goncalo S+, Contact Dermatitis 21(3), 200
(1985): Brener S+, Contact Dermatitis 12(4), 230
(1983): Gawkrodger DJ+, Contact Dermatitis 9(3), 224
(1983): Heskel NS+, Contact Dermatitis 9(4), 278
Vesiculation
(1985): Brener S+, Contact Dermatitis 12(4), 230
(1983): Heskel NS+, Contact Dermatitis 9(4), 278
Other
Death
SACCHARIN
Trade names: Saccharin; Sweet ’n Low
Indications: Sugar substitute
Category: Sweetening agent
Half-life: N/A
Reactions
Skin
Dermatitis
(1989): Birbeck J, NZMedJ102, 24
Exanthems
Fixed eruption
Photosensitivity
Pruritus
(1989): Birbeck J, NZMedJ102, 24
Sensitivity (sic)
Urticaria
SACCHARIN 489