02.06.2013 Views

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Other<br />

Inappropriate secretion of antidiuretic hormone (SIADH)<br />

(2001): Chitre MM+, Pharmacotherapy 21(4), 493<br />

Myalgia/Myositis/Myopathy/Myotoxicity (2%)<br />

RIFAMPIN<br />

Synonym: rifampicin<br />

Trade names: Abrifam; Corifam; Ramicin; Rifadin (Sanofi-<br />

Aventis); Rifaldin; Rifamed; Rimactane (Novartis); Rimpin;<br />

Rimycin; Rofact<br />

Indications: Tuberculosis<br />

Category: Antibiotic, rifamycin<br />

Half-life: 3–5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amiodarone, amprenavir, anisindione, antacids,<br />

anticoagulants, aprepitant, atazanavir, atovaquone,<br />

beclomethasone, buprenorphine, corticosteroids, cortisone,<br />

cyclosporine, dapsone, darunavir, delavirdine, dexamethasone,<br />

dicumarol, digoxin, flunisolide, fosamprenavir, halothane,<br />

imatinib, isoniazid, itraconazole, ketoconazole, lapatinib,<br />

methylprednisolone, midazolam, nelfinavir, nifedipine, oral<br />

contraceptives, prednisone, protease inhibitors, pyrazinamide,<br />

ramelteon, ritonavir, saquinavir, solifenacin, sunitinib, tacrolimus,<br />

telithromycin, temsirolimus, tipranavir, triamcinolone, triazolam,<br />

voriconazole, warfarin, zaleplon<br />

Reactions<br />

Skin<br />

Acne<br />

(1990): Mimouni A+, <strong>Drug</strong> Intell Clin Pharm 24, 947<br />

(1985): Holdiness MR, Int J Dermatol 24, 280<br />

Acute generalized exanthematous pustulosis<br />

(2006): Azad A+, Intern Med J 36(9), 619<br />

Allergic reactions (sic)<br />

Angioedema<br />

(1989): Holdiness MR, Med Toxicol Adv <strong>Drug</strong> Exp 4, 444 (72%)<br />

Bullous dermatitis (

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!