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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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460 PROPYLTHIOURACIL<br />

PROPYLTHIOURACIL<br />

Trade names: Propacil; Propycil; Propyl-Thyracil (Paladin); Tiotil<br />

Indications: Hyperthyroidism<br />

Category: Antithyroid, hormone modifier<br />

Half-life: 1–5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticoagulants, dicumarol, myrrh, warfarin<br />

Reactions<br />

Skin<br />

Acne<br />

(1980): Vasily DB+, JAMA 243, 458<br />

Acute febrile neutrophilic dermatosis (Sweet’s syndrome)<br />

(2005): Boulenger-Vazel A+, Ann Dermatol Venereol 132(1), 27<br />

(1999): Miller RM+, Br J Dermatol 141(5), 943<br />

Adverse effects (sic)<br />

(1982): Pacini F+, J Endocrinol Invest 5, 403<br />

Angioedema (1%)<br />

(1980): Vasily DB+, JAMA 243, 458<br />

Dermatitis<br />

(1993): Elias AN+, JAmAcadDermatol29, 78<br />

Edema (

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