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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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456 PROMETHAZINE<br />

PROMETHAZINE<br />

Trade names: Anergan; Atosil; Bonnox; Closin; Goodnight;<br />

Histantil; Pentazine; Phenazine; Phenergan (Wyeth); Prometh-50;<br />

Prothiazine; Pyrethia<br />

Indications: Allergic rhinitis, urticaria<br />

Category: Antipsychotic, phenothiazine; Histamine H1 receptor<br />

antagonist<br />

Half-life: 10–14 hours<br />

Clinically important, potentially hazardous interactions<br />

with: antihistamines, arsenic, chlorpheniramine, dofetilide,<br />

nalbuphine, piperazine, quinolones, sparfloxacin, zaleplon<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (

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