Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Xerosis Mucosal Lip ulceration (1984): Reilly GD+, Acta Derm Venereol (Stockh) 64, 270 Sialorrhea Tongue pigmentation (1989): Alroe C+, Med J Aust 150, 724 Xerostomia (>10%) Other Anaphylactoid reactions/Anaphylaxis (1–10%) Gynecomastia (1–10%) PROCYCLIDINE Trade names: Apricolin; Kemadren; Kemadrin (Monarch); Onservan; Procyclid Indications: Parkinsonism Category: Muscarinic antagonist Half-life: N/A Duration of action: 4 hours Clinically important, potentially hazardous interactions with: anticholinergics, arbutamine Skin Photosensitivity (1–10%) Rash (sic) (10%) Mucosal Xerostomia (>10%) PROGESTINS Reactions Generic names: Hydroxyprogesterone Trade names: Delta-Lutin; Duralutin; Hylutin; Pro-Depo; Prodrox Medroxyprogesterone Trade names: Curretab; Provera (Pfizer) Megestrol Trade name: Megace Norethindrone Trade names: Aygestin (Barr); Micronor; Norlutin; Norlutate; Nor-QD Norgestrol Trade name: Ovrette Progesterone Trade names: Gesterol 50; Progestaject Category: Progestogen Half-life: N/A Clinically important, potentially hazardous interactions with: acitretin, dofetilide Reactions Skin Acne (2003): Cohen EB+, Ned Tijdschr Geneeskd 147(43), 2137 (implant) (1995): Freeman EW+, JAMA 274, 51 Acute generalized exanthematous pustulosis (AGEP) (1998): Kuno Y+, Acta Derm Venereol 78, 383 Angioedema Dermatitis (2001): Izu K+, JUOEH23(4), 431 Diaphoresis (31%) (1990): Willemse PHB+, Eur J Cancer 26, 337 (31%) Edema Erythema multiforme (2005): Suzuki R+, Br J Dermatol 152(2), 370 (1985): Wojnarowska F+, JRSocMed78, 407 Erythema nodosum Exanthems Hemorrhage Melasma Peripheral edema Pruritus Rash (sic) Telangiectasia Urticaria (1995): Shelley WB+, Cutis 55, 282 (observation) (1994): Shelley WB+, Cutis 55, 21 (observation) (1994): Yee KC+, Br J Dermatol 130, 121 Hair Hair – alopecia Hair – hirsutism Other Anaphylactoid reactions/Anaphylaxis Gynecomastia (painful) PROMAZINE Trade names: Liranol; Prazine; Protactyl; Savamine; Talofen Indications: Psychotic disorders, schizophrenia Category: Antipsychotic, phenothiazine Half-life: 24 hours Clinically important, potentially hazardous interactions with: sparfloxacin Reactions PROMAZINE 455 Skin Dermatitis Edema Exanthems Photosensitivity (1–10%) Phototoxicity (1997): Eberlein-Konig B+, Dermatology 194(2), 131 (16%) (1985): Chignell CF+, Environ Health Perspect 64, 103 (1985): Motten AG+, Photochem Photobiol 42, 9 Pigmentation (
456 PROMETHAZINE PROMETHAZINE Trade names: Anergan; Atosil; Bonnox; Closin; Goodnight; Histantil; Pentazine; Phenazine; Phenergan (Wyeth); Prometh-50; Prothiazine; Pyrethia Indications: Allergic rhinitis, urticaria Category: Antipsychotic, phenothiazine; Histamine H1 receptor antagonist Half-life: 10–14 hours Clinically important, potentially hazardous interactions with: antihistamines, arsenic, chlorpheniramine, dofetilide, nalbuphine, piperazine, quinolones, sparfloxacin, zaleplon Reactions Skin Allergic reactions (sic) (
- Page 480 and 481: Chills (5-10%) Hypersensitivity (
- Page 482 and 483: OXACILLIN Trade names: Bactocill; B
- Page 484 and 485: Other Anaphylactoid reactions/Anaph
- Page 486 and 487: OXYMORPHONE Synonym: 14-hydroxy-dih
- Page 488 and 489: (2001): Robinson JB+, Gynecol Oncol
- Page 490 and 491: PANCRELIPASE Trade names: Cotazym (
- Page 492 and 493: Exanthems Fixed eruption (1994): Ki
- Page 494 and 495: (2006): Bettoli V+, Acta Derm Vener
- Page 496 and 497: Reactions Skin Adverse effects (sic
- Page 498 and 499: (1981): Hashimoto K+, JAmAcadDermat
- Page 500 and 501: Hypersensitivity (1999): Hsu HL+, T
- Page 502 and 503: Injection-site calcification (1991)
- Page 504 and 505: PEPPERMINT Scientific name: Mentha
- Page 506 and 507: (1995): Magro CM+, JAmAcadDermatol3
- Page 508 and 509: (1993): Leenutaphong V+, Int J Derm
- Page 510 and 511: PHENYLEPHRINE Trade names: Dionephr
- Page 512 and 513: (1991): Kleier RS, Arch Dermatol 12
- Page 514 and 515: Lymphoproliferative disease (1992):
- Page 516 and 517: (2006): Andersen KE+, Contact Derma
- Page 518 and 519: Oral candidiasis Stomatodynia Vagin
- Page 520 and 521: Reactions Skin Exanthems Petechiae
- Page 522 and 523: Reactions Skin Acne (1-10%) Angioed
- Page 524 and 525: Pruritus (
- Page 526 and 527: PREDNISONE Trade names: Deltasone (
- Page 528 and 529: Other Anticonvulsant hypersensitivi
- Page 532 and 533: (1982): Gall H+, Derm Beruf Umwelt
- Page 534 and 535: (2006): Barkin RL+, Am J Ther 13(6)
- Page 536 and 537: PROTAMINE SULFATE Indications: Hepa
- Page 538 and 539: (1987): Shelley WB+, JAmAcadDermato
- Page 540 and 541: Hypersensitivity Myalgia/Myositis/M
- Page 542 and 543: (1999): Drayton G, Los Angeles, CA
- Page 544 and 545: (1986): Bigby M+, JAMA 256, 3358 (1
- Page 546 and 547: Nails Nails - photo-onycholysis (19
- Page 548 and 549: Hair Hair - alopecia (1-10%) Other
- Page 550 and 551: RASBURICASE Trade names: Elitek (Sa
- Page 552 and 553: RETEPLASE Synonyms: recombinant pla
- Page 554 and 555: Other Inappropriate secretion of an
- Page 556 and 557: Tongue pigmentation Vulvovaginal ca
- Page 558 and 559: Reactions Skin Acne (
- Page 560 and 561: RIZATRIPTAN Synonym: MK462 Trade na
- Page 562 and 563: Glossitis (1%) Stomatitis (
- Page 564 and 565: (1995): Brandstatter G+, Clin Ther
- Page 566 and 567: Mucosal Cheilitis (
- Page 568 and 569: SELENIUM Trade names: Bio-Active Se
- Page 570 and 571: Mucosal Aphthous stomatitis (
- Page 572 and 573: (2004): Vasconcelos OM+, Muscle Ner
- Page 574 and 575: (2005): Mahe E+, Transplantation 79
- Page 576 and 577: SOLIFENACIN Trade name: Vesicare (G
- Page 578 and 579: Urticaria (
Xerosis<br />
Mucosal<br />
Lip ulceration<br />
(1984): Reilly GD+, Acta Derm Venereol (Stockh) 64, 270<br />
Sialorrhea<br />
Tongue pigmentation<br />
(1989): Alroe C+, Med J Aust 150, 724<br />
Xerostomia (>10%)<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis (1–10%)<br />
Gynecomastia (1–10%)<br />
PROCYCLIDINE<br />
Trade names: Apricolin; Kemadren; Kemadrin (Monarch);<br />
Onservan; Procyclid<br />
Indications: Parkinsonism<br />
Category: Muscarinic antagonist<br />
Half-life: N/A<br />
Duration of action: 4 hours<br />
Clinically important, potentially hazardous interactions<br />
with: anticholinergics, arbutamine<br />
Skin<br />
Photosensitivity (1–10%)<br />
Rash (sic) (10%)<br />
Mucosal<br />
Xerostomia (>10%)<br />
PROGESTINS<br />
Reactions<br />
Generic names:<br />
Hydroxyprogesterone<br />
Trade names: Delta-Lutin; Duralutin; Hylutin; Pro-Depo;<br />
Prodrox<br />
Medroxyprogesterone<br />
Trade names: Curretab; Provera (Pfizer)<br />
Megestrol<br />
Trade name: Megace<br />
Norethindrone<br />
Trade names: Aygestin (Barr); Micronor; Norlutin; Norlutate;<br />
Nor-QD<br />
Norgestrol<br />
Trade name: Ovrette<br />
Progesterone<br />
Trade names: Gesterol 50; Progestaject<br />
Category: Progestogen<br />
Half-life: N/A<br />
Clinically important, potentially hazardous interactions<br />
with: acitretin, dofetilide<br />
Reactions<br />
Skin<br />
Acne<br />
(2003): Cohen EB+, Ned Tijdschr Geneeskd 147(43), 2137<br />
(implant)<br />
(1995): Freeman EW+, JAMA 274, 51<br />
Acute generalized exanthematous pustulosis (AGEP)<br />
(1998): Kuno Y+, Acta Derm Venereol 78, 383<br />
Angioedema<br />
Dermatitis<br />
(2001): Izu K+, JUOEH23(4), 431<br />
Diaphoresis (31%)<br />
(1990): Willemse PHB+, Eur J Cancer 26, 337 (31%)<br />
Edema<br />
Erythema multiforme<br />
(2005): Suzuki R+, Br J Dermatol 152(2), 370<br />
(1985): Wojnarowska F+, JRSocMed78, 407<br />
Erythema nodosum<br />
Exanthems<br />
Hemorrhage<br />
Melasma<br />
Peripheral edema<br />
Pruritus<br />
Rash (sic)<br />
Telangiectasia<br />
Urticaria<br />
(1995): Shelley WB+, Cutis 55, 282 (observation)<br />
(1994): Shelley WB+, Cutis 55, 21 (observation)<br />
(1994): Yee KC+, Br J Dermatol 130, 121<br />
Hair<br />
Hair – alopecia<br />
Hair – hirsutism<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis<br />
Gynecomastia (painful)<br />
PROMAZINE<br />
Trade names: Liranol; Prazine; Protactyl; Savamine; Talofen<br />
Indications: Psychotic disorders, schizophrenia<br />
Category: Antipsychotic, phenothiazine<br />
Half-life: 24 hours<br />
Clinically important, potentially hazardous interactions<br />
with: sparfloxacin<br />
Reactions<br />
PROMAZINE 455<br />
Skin<br />
Dermatitis<br />
Edema<br />
Exanthems<br />
Photosensitivity (1–10%)<br />
Phototoxicity<br />
(1997): Eberlein-Konig B+, Dermatology 194(2), 131 (16%)<br />
(1985): Chignell CF+, Environ Health Perspect 64, 103<br />
(1985): Motten AG+, Photochem Photobiol 42, 9<br />
Pigmentation (
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