Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Other
Anticonvulsant hypersensitivity syndrome
(2002): Kaur S+, Pediatr Dermatol 19(2), 142
Hypersensitivity
(2002): Krivo JM, Franklin Square, NY (from Internet)
(observation)
(1998): Schlienger RG+, Epilepsia 39, S3 (passim)
Rhabdomyolysis
(1990): Larpin R+, Presse Med 19(30), 1403
PROBENECID
Trade names: Bencid; Benecid; Benuryl; Panuric; Probalan;
Procid; Solpurin; Urocid
Indications: Gouty arthritis
Category: Uricosuric
Half-life: 6–12 hours (dose-dependent)
Clinically important, potentially hazardous interactions
with: amphotericin B, benzodiazepines, ertapenem, furosemide,
glibenclamide, ketoprofen, ketorolac, methotrexate, NSAIDs,
pemetrexed, penicillamine, penicillin G, penicillin V, salicylates,
sulfamethoxazole, sulfonamides
Reactions
Skin
Allergic reactions (sic)
Dermatitis
Erythema multiforme
(1985): Ting HC+, Int J Dermatol 24, 587
Exanthems
Pruritus (1–10%)
Rash (sic) (1–10%)
Urticaria (1–5%)
Mucosal
Gingivitis (1–10%)
Hair
Hair – alopecia
Other
Anaphylactoid reactions/Anaphylaxis (5%)
(1985): Kale SA, Postgrad Med 77, 231
(1985): Lovisetto P+, Recenti Prog Med (Italian) 76, 110
(1985): Rubin RL+, Clin Immunol Immunopathol 36, 49
(1985): Stratton MA, Clin Pharm 4, 657
(1985): Totoritis MC+, Postgrad Med 78, 149
(1984): Browning CA+, Am J Cardiol 53, 376
(1984): Goldberg SK+, Am J Med 76, 146