Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

PREDNISONE
Trade names: Deltasone (Pharmacia); Meticorten (Schering)
Indications: Arthralgias, Asthma, Dermatoses, Ophthalmology
(many others)
Category: Corticosteroid, systemic
Half-life: N/A
Clinically important, potentially hazardous interactions
with: aluminum, aminophylline, aspirin, chlorambucil, cimetidine,
clarithromycin, cyclophosphamide, cyclosporine, dicumarol,
diuretics, docetaxel, estrogens, grapefruit juice, indomethacin,
itraconazole, ketoconazole, lansoprazole, live vaccines,
methotrexate, montelukast, omeprazole, oral contraceptives,
pancuronium, phenobarbital, phenytoin, ranitidine, rifampicin,
rifampin, timolol, tolbutamide, vitamin A
Reactions
Skin
Acanthosis nigricans
(1980): Gottlieb NL+, JAMA 243, 1260
Acne
Allergic reactions (sic)
(1999): Alexiou C+, Laryngorhinootologie (German) 78, 573
Atrophy
Bruising
Cellulitis
(2004): Lafleur L+, Cutis 74(3), 165
Dermatitis
(2003): Levine A+, J Pediatr Gastroenterol Nutr 36(2), 248
(2000): Chew AL+, Cutis 65, 307
(2000): Harris A+, Australas J Dermatol 41, 124
Dermatofibromas
(2002): Massone C+, Int J Dermatol 41(5), 279
Diaphoresis
(1999): Alexiou C+, Laryngorhinootologie (German) 78, 573
Eczema
(2000): Bircher AJ+, Dermatology 200(4), 349
Edema
Erythema
(1999): Alexiou C+, Laryngorhinootologie (German) 78, 573
Linear hypopigmentation
(1980): Gottlieb L+, Arch Dermatol 140, 1507
Lymphoma
(2004): Cohen Y+, Eur J Haematol 73(2), 134
Pruritus
(1999): Alexiou C+, Laryngorhinootologie (German) 78, 573
Purpura
(1990): Capewell S+, BMJ 300, 1548
Rash (sic)
(2003): Prasad GV+, Clin Transplant 17(2), 135
Sensitivity
(2000): Bircher AJ+, Dermatology 200(4), 349
Squamous cell carcinoma
(2003): Hernandez G+, Oral Oncol 39(1), 87
(2002): Preciado DA+, Head Neck 24(4), 319
Staphylococcal scalded skin syndrome
(1998): Shirin S+, Cutis 62, 223 (in an adult)
Thinning
(1990): Capewell S+, BMJ 300, 1548
Toxicoderma
(1996): Mathelier-Fusade P+, Ann Dermatol Venereol 123(8), 453
Urticaria
(1990): Ashford RF+, Postgrad Med J 56, 437
Mucosal
Leukoplakia
(2003): Hernandez G+, Oral Oncol 39(1), 87
Hair
Hair – hypertrichosis
Eyes
Cataract
(2004): Matas AJ+, Ann Surg 240(3), 510
(2001): Ghodsi Z+, Transfusion 41(12), 1464
Chorioretinopathy
(2002): Bandello F+, Eur J Ophthalmol 12(2), 123
Glaucoma
(2000): Derzko-Dzulynsky L+, Am J Ophthalmol 129(6), 807
Uveitis
(2003): Zamani M+, Am J Ophthalmol 135(6), 891
Vision impaired
Other
Adverse effects (sic)
(2004): Caporali R+, AnnInternMed141(7), 493
(2003): Gladman DD+, J Rheumatol 30(9), 1955
(2003): Proven A+, Arthritis Rheum 49(5), 703
(2002): Khumalo NP+, Arch Dermatol 138(3), 385
Anaphylactoid reactions/Anaphylaxis
(1995): Jacqz-Aigrain E+,, Arch Pediatr (French) 2, 353
Infections
(2004): Arend SM+, Eur J Clin Microbiol Infect Dis 23(8), 638
(with infliximab)
(2004): Uzuka T+, No Shinkei Geka 32(2), 127
(2003): Casals DS+, JDermatol30(4), 332
(2003): Prasad GV+, Clin Transplant 17(2), 135
(2003): Yoo SS+, JDermatol30(5), 405
(2000): Hovi L+, Bone Marrow Transplant 26(9), 999
Lipomatosis
(2002): ter Borg EJ+, Ned Tijdschr Geneeskd 146(2), 67
Myalgia/Myositis/Myopathy/Myotoxicity
(2004): Miozzari M+, NephrolDialTransplant19(10), 2615
Side effects (sic)
(2003): Lande MB+, Pediatr Nephrol 18(4), 342
(2002): Joly P+, NEnglJMed346(5), 321
(2001): Macchia PE+, J Endocrinol Invest 24(3), 152
Tendinopathy/Tendon rupture
(2002): Khurana R+, Respirology 7(2), 161
PREGABALIN
Trade name: Lyrica (Pfizer)
Indications: Neuropathy, Post-herpetic neuralgia, Partial
epilepsy
Category: Anticonvulsant; GABA analog
Half-life: 6 hours
Reactions
PREGABALIN 451
Skin
Abscess
Allergic granulomatous angiitis (Churg–Strauss syndrome)
Angioedema
Atrophy
Cellulitis
Eczema
Edema (2%)
Exfoliative dermatitis
Lichenoid eruption