Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Reactions
Skin
Acne (1–10%)
Angioedema (1–10%)
Bullous pemphigoid
(1994): Piletta P+, Br J Dermatol 131, 145
Dermatitis (systemic)
(2004): Sicherer SH, J Allergy Clin Immunol 114(6), 1395
Dermatitis herpetiformis
(1989): Zone JJ+, Immunol Ser 46, 565
Diaphoresis
Exanthems
(1981): Farkas J, Dermatol Monatsschr (German) 167, 579
Iododerma
(1996): Alpay K+, Pediatr Dermatol 13, 51
(1990): Soria C+, JAmAcadDermatol22, 418 (vegetating)
(1989): Romanenko VN+, Vestn Dermatol Venerol (Russian)
12, 60
(1987): O’Brien TJ, Australas J Dermatol 28, 119
(1986): Raznatovskii IM+, Vestn Dermatol Venerol (Russian)
10, 71
(1985): Stone OJ, Int J Dermatol 24, 565
(1985): Wilkin JK+, Cutis 36, 335
(1981): Huang TY+, Ann Allergy 46, 264
Lupus erythematosus
Psoriasis
Purpura
Rash (sic)
Urticaria (1–10%)
Vasculitis
(1987): Eeckhout E+, Acta Derm Venereol (Stockh) 67, 362
(1981): Zone JJ, Arch Dermatol 117, 758
Mucosal
Gingivitis
Sialorrhea
Stomatodynia
Other
Anaphylactoid reactions/Anaphylaxis
(2004): Sicherer SH, J Allergy Clin Immunol 114(6), 1395
Serum sickness
PRAMIPEXOLE
Trade name: Mirapex (Pfizer) (Boehringer Ingelheim)
Indications: Parkinsonism
Category: Dopamine receptor agonist
Half-life: ~8 hours
Reactions
Skin
Adverse effects (sic) (2%)
Allergic reactions (sic) (>1%)
Diaphoresis (>1%)
Edema (5%)
Peripheral edema (5%)
(2000): Tan EK+, Arch Neurol 57, 729
Pruritus (>1%)
Rash (sic) (>1%)
Vasculitis
(2004): Famularo G+, Clin Exp Rheumatol 22(6), 785
Mucosal
Sialorrhea (>1%)
Xerostomia (7%)
(2006): Montplaisir J+, Eur J Neurol 13(12), 1306 (2%)
(1998): Dooley M+, Drugs Aging 12, 495
Hair
Hair – alopecia
(2006): Katz KA+, JAmAcadDermatol55(5), S103
Eyes
Dyschromatopsia
(2003): Muller T+, JNeurol250(1), 101
Other
Inappropriate secretion of antidiuretic hormone (SIADH)
(2005): Tomita M+, Nippon Jinzo Gakkai Shi 47(5), 531
Myalgia/Myositis/Myopathy/Myotoxicity (>1%)
Nephrotoxicity
(2004): Famularo G+, Clin Exp Rheumatol 22(6), 785
PRAMLINTIDE
Trade name: Symlin (Amlin)
Indications: Diabetes, Adjunct to insulin treatment
Category: Amylinomimetic; Protein analog
Half-life: 48 minutes
Clinically important, potentially hazardous interactions
with: acarbose, acetaminophen, alcohol, anticholinergic agents,
atropine, miglitol
Skin
Allergic reactions (sic) (6%)
Diaphoresis
Other
Abdominal pain (8%)
Cough (6%)
Injection-site edema
Injection-site pain
Injection-site pruritus
PRAVASTATIN
Reactions
Trade names: Elisor; Lipostat; Pravachol (Bristol-Myers Squibb);
Pravasin; Pravasine; Selectin; Selektine; Selipran
Indications: Hypercholesterolemia
Category: HMG-CoA reductase inhibitor; Statin
Half-life: ~2–3 hours
Clinically important, potentially hazardous interactions
with: azithromycin, ciprofibrate, clarithromycin, cyclosporine,
darunavir, erythromycin, gemfibrozil, imatinib, red rice yeast
Reactions
Skin
Allergic reactions (sic)
(1994): de Boer EM+, Contact Dermatitis 30, 238
Angioedema
Dermatomyositis
(2005): Zuech P+, Rev Med Interne 26(11), 897
(1992): Schalke BB+, NEnglJMed327, 649
PRAVASTATIN 447