Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Reactions
Skin
Exanthems
Petechiae (1–10%)
Purpura (10%)
Seborrheic keratoses (inflammation of)
(1987): Johnson TM+, JAmAcadDermatol17, 192
Toxic epidermal necrolysis
Mucosal
Oral lesions (1–15%)
(1989): Kerker BJ+, Semin Dermatol 8, 173 (1–5%)
Stomatitis (>10%)
Other
Injection-site cellulitis (1–10%)
Injection-site erythema (1–10%)
Injection-site pain (1–10%)
PNEUMOCOCCAL VACCINE
Trade names: PCV (Lederle); PncOMP (Merck); Pneumovax II
(Sanofi-Aventis); Pnu-Immune (Lederle); PPV (Lederle); Prevenar
(Wyeth)
Indications: Prevention of bacteremia, meningitis, pneumonia,
respiratory tract infections, otitis media, sinusitis
Category: Vaccine
Half-life: N/A
Reactions
Skin
Dermatitis
(2003): Holdiness MR+, South Med J 96(1), 64
Facial edema
(2002): Kikuchi Y+, Clin Nephrol 58(1), 68
Peripheral edema
(2002): Kikuchi Y+, Clin Nephrol 58(1), 68
Petechiae
(2003): Holdiness MR+, South Med J 96(1), 64
Pityriasis rosea
(2003): Sasmaz S+, JDermatol30(3), 245
Pruritus
(2003): Holdiness MR+, South Med J 96(1), 64
Rash (sic)
(2006): Prescrire Int 15(86), 227
(2004): Wise RP+, JAMA 292(14), 1702
Urticaria
(2006): Prescrire Int 15(86), 227
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2004): Wise RP+, JAMA 292(14), 1702
(2003): Holdiness MR+, South Med J 96(1), 64
(2002): Black S+, Eur J Pediatr 161 Suppl 2, S127
Eyes
Photophobia
(2005): Hasan S+, J Natl Med Assoc 97(2), 284
Uveitis
(2002): Kikuchi Y+, Clin Nephrol 58(1), 68
Visual disturbances
(2002): Kikuchi Y+, Clin Nephrol 58(1), 68
Other
Anaphylactoid reactions/Anaphylaxis
(2004): Wise RP+, JAMA 292(14), 1702
POLYPODIUM LEUCOTOMOS 445
(2001): Ponvert C+, Vaccine 19(32), 4588
Fever
(2006): Prescrire Int 15(86), 227
(2006): Shao PL+, J Formos Med Assoc 105(7), 542
(2005): de Aristegui Fernandez J+, Vaccine 23(16), 1917 (7%)
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2005): Jackson LA+, Vaccine 23(28), 3697
(2004): Socan M+, Vaccine 22(23–24), 3087
(2004): Wise RP+, JAMA 292(14), 1702
(2002): Prescrire Int 11(57), 7
(2002): Black S+, Eur J Pediatr 161 Suppl 2, S127
(2002): D’heilly S+, Am J Infect Control 30(5), 261
(2002): Darkes MJ+, Paediatr Drugs 4(9), 609
(2002): Shinefield H+, Pediatr Infect Dis J 21(3), 182
(2000): Suda T, Nihon Kokyuki Gakkai Zasshi 38(11), 836
Hypersensitivity
(2002): Kikuchi Y+, Clin Nephrol 58(1), 68
Injection-site edema
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2004): Socan M+, Vaccine 22(23–24), 3087
(2002): Black S+, Eur J Pediatr 161 Suppl 2, S127
(2002): D’heilly S+, Am J Infect Control 30(5), 261 (23%)
(2002): Shinefield H+, Pediatr Infect Dis J 21(3), 182
(2000): Suda T, Nihon Kokyuki Gakkai Zasshi 38(11), 836
Injection-site erythema
(2005): de Aristegui Fernandez J+, Vaccine 23(16), 1917 (40%)
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2005): Hasan S+, J Natl Med Assoc 97(2), 284
(2004): Socan M+, Vaccine 22(23–24), 3087
(2002): Black S+, Eur J Pediatr 161 Suppl 2, S127
(2002): D’heilly S+, Am J Infect Control 30(5), 261 (23%)
(2002): Shinefield H+, Pediatr Infect Dis J 21(3), 182
(2000): Suda T, Nihon Kokyuki Gakkai Zasshi 38(11), 836
Injection-site induration
(2005): de Aristegui Fernandez J+, Vaccine 23(16), 1917 (32%)
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2005): Hasan S+, J Natl Med Assoc 97(2), 284
Injection-site inflammation
(2002): Darkes MJ+, Paediatr Drugs 4(9), 609
Injection-site pain
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2005): Hasan S+, J Natl Med Assoc 97(2), 284
(2002): D’heilly S+, Am J Infect Control 30(5), 261 (23%)
(2000): Suda T, Nihon Kokyuki Gakkai Zasshi 38(11), 836
Injection-site reactions
(2006): Prescrire Int 15(86), 227
(2006): Jackson LA+, Vaccine 24(2), 151
(2005): Ghaffar F, Expert Opin Drug Saf 4(4), 631
(2005): Jackson LA+, Vaccine 23(28), 3697
(2005): Lin PL+, Pediatrics 116(1), 160
(2004): Wise RP+, JAMA 292(14), 1702
(2002): Prescrire Int 11(57), 7
Myalgia/Myositis/Myopathy/Myotoxicity
(2004): Socan M+, Vaccine 22(23–24), 3087
Serum sickness
(2006): Hengge UR+, IntJSTDAIDS17(3), 210
(2004): Wise RP+, JAMA 292(14), 1702
POLYPODIUM LEUCOTOMOS
Synonym: Polypodiaceae
Trade names: Anapsos; Calagualine; Calagula; Difur; Fernblock;
Heliocare; Polypodium leucotomos
Indications: Oral and topical photoprotection, vitiligo, psoriasis,
dermatitis, arthritis
Category: Anti-inflammatory; Antioxidant
Half-life: N/A