Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

442 PINDOLOL
Eyes
Oculo-mucocutaneous syndrome
(1982): Cocco G+, Curr Ther Res 31, 362
Other
Myalgia/Myositis/Myopathy/Myotoxicity
(1980): Uusitupa M+, BMJ 1, 183
Peyronie’s disease
PIOGLITAZONE
Trade name: Actos (Takeda)
Indications: Type 2 diabetes
Category: Thiazolidinedione
Half-life: 3–7 hours
Clinically important, potentially hazardous interactions
with: gemfibrozil
Reactions
Skin
Angioedema
(2002): Shadid S+, Diabetes Care 25(2), 405
Edema (4–11%)
(2005): 16106595
OWN, Prescrire Int 14(78), 133
(2005): Belcher G+, Diabetes Res Clin Pract 70(1), 53
(2005): Bongartz T+, Rheumatology (Oxford) 44(1), 126
(2005): Charbonnel BH+, Diabet Med 22(4), 399
(2005): Kahara T+, Endocr J 52(3), 373
(2003): Mudaliar S+, Endocr Pract 9(5), 406
(2002): Prescrire Int 11(62), 170
(2001): Chilcott J+, Clin Ther 23(11), 1792 (11.7%)
(2001): Toyota T, Nippon Rinsho 59(11), 2211
Eyes
Dyschromatopsia
(2003): Muller T+, JNeurol250(1), 101
Other
Hepatotoxicity
(2005): Prescrire Int 14(78), 133
(2004): Arotcarena R+, Gastroenterol Clin Biol 28(6–7), 610
(2004): Farley-Hills E+, BMJ 329(7463), 429
(2004): Marcy TR+, Ann Pharmacother 38(9), 1419 (5 cases)
(2002): Pinto AG+, AnnInternMed137(10), 857
Myalgia/Myositis/Myopathy/Myotoxicity (5.4%)
PIPECURONIUM
Trade name: Arduan (Organon)
Indications: Adjunct to general anesthesia
Category: Non-depolarizing neuromuscular blocker
Half-life: 2–3 hours
Clinically important, potentially hazardous interactions
with: anesthetics (inhalational), antibiotics, gentamicin,
magnesium salts, quinidine, succinylcholine
Skin
Rash (sic) (