Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Lymphoproliferative disease
(1992): Schlaifer D+, Eur J Hematol 48, 274
Myalgia/Myositis/Myopathy/Myotoxicity
(1986): Engel JN+, Am J Med 81, 928
(1983): Harney J+, Neurology 33, 790
Neurotoxicity
(2004): Toth C+, J Peripher Nerv Syst 9(4), 198
Peyronie’s disease
Polyarteritis nodosa
Porphyria
(1980): Fuchs T+, Int J Biochem 12, 955
Porphyria cutanea tarda
(1996): Ruggian JC+, JAmSocNephrol7, 397
Pseudolymphoma (10%)
Eyes
Epiphora (>10%)
Ocular burning (1–10%)
Ocular stinging (>10%)
Other
Death
Note: Antilirium is a derivative of the Calabar bean, and its active
moiety, physostigmine, is also known as eserine.
Note: Physostigmine is used to reverse the effect upon the nervous
system caused by clinical or toxic dosages of drugs and herbs capable
of producing the anticholinergic syndrome.
Some of the drugs responsible are: amitriptyline, amoxapine,
atropine, benztropine, biperiden, clidinium, cyclobenzaprine,
desipramine, doxepin, hyoscyamine, imipramine, lorazepam,
maprotiline, nortriptyline, protriptyline, propantheline, scopolamine,
trimipramine. Some herbals that can elicit the anticholinergic
syndrome are black henbane, deadly nightshade, Devil’s apple, Jimson
weed, Loco seeds or weeds, Matrimony vine, night blooming
jessamine, stinkweed.
PHYTONADIONE
Synonyms: phylloquinone; phytomenadione; vitamin K 1
Trade names: Kaywan; Konakion; Mephyton; Phytomenadione;
Vitak; Vitamin K (Abbott)
Indications: Coagulation disorders
Category: Vitamin
Half-life: 2–4 hours
Clinically important, potentially hazardous interactions
with: warfarin
Reactions
PHYTONADIONE 439
Skin
Allergic reactions (sic)
(1999): Wong DA+, Australas J Dermatol 40, 147
(1990): Pigatto PD+, Contact Dermatitis 22, 307
Dermatitis
(2006): Ruiz-Hornillos FJ+, Contact Dermatitis 55(4), 246
(2005): Serra-Baldrich E+, Contact Dermatitis 53(3), 174
(1999): Drayton G, Los Angeles, CA (from Internet)
(observation)
(1995): Bruynzeel I+, Contact Dermatitis 32, 78
(1995): Guy C+, Therapie (French) 50, 483
(1988): Dinis A+, Contact Dermatitis 18, 170
(1982): Camarasa JG+, Contact Dermatitis 8, 268
(1980): Romaguera C+, Contact Dermatitis 6, 355
Diaphoresis (