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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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434 PHENOXYBENZAMINE<br />

PHENOXYBENZAMINE<br />

Trade names: Dibenyline; Dibenzyline (Wellspring); Dibenzyran<br />

Indications: Pheochromocytoma<br />

Category: Adrenergic alpha-receptor antagonist<br />

Half-life: 24 hours<br />

Clinically important, potentially hazardous interactions<br />

with: epinephrine<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

Dermatitis<br />

(1998): Sommer S+, Contact Dermatitis 38(6), 352<br />

Mucosal<br />

Xerostomia (1–10%)<br />

(1981): Kedia KR+, Urology 18(6), 620<br />

Other<br />

Death<br />

(2006): Vaidyanathan S+, Spinal Cord 44(3), 188<br />

PHENSUXIMIDE<br />

Trade name: Milontin<br />

Indications: Petit mal seizures<br />

Category: Anticonvulsant<br />

Half-life: 5–12 hours<br />

Reactions<br />

Skin<br />

Erythema multiforme (

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