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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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432 PHENELZINE<br />

Photosensitivity<br />

(1988): Case JD+, Photodermatology 5, 101<br />

Pruritus (13%)<br />

Rash (sic)<br />

Telangiectasia<br />

Urticaria<br />

Mucosal<br />

Glossitis<br />

(1992): Zürcher K+, Cutaneous <strong>Drug</strong> Reactions Karger, Basel<br />

(passim)<br />

Tongue black<br />

Xerostomia (1–10%)<br />

Other<br />

Inappropriate secretion of antidiuretic hormone (SIADH)<br />

(1989): Giese AA+, J Clin Psychopharmacol 9(4), 309<br />

Rhabdomyolysis<br />

(1984): Linden CH+, Ann Emerg Med 13(12), 1137<br />

PHENINDAMINE<br />

Trade name: Nolahist<br />

Indications: Allergic rhinitis, urticaria, angioedema<br />

Category: Histamine H1 receptor antagonist<br />

Half-life: N/A<br />

Skin<br />

Angioedema<br />

Dermatitis<br />

Diaphoresis<br />

Erythema<br />

Lupus erythematosus<br />

Photosensitivity<br />

Purpura<br />

Rash (sic)<br />

Urticaria<br />

Mucosal<br />

Xerostomia<br />

Reactions<br />

PHENOBARBITAL<br />

Synonyms: phenobarbitone; phenylethylmalonylurea<br />

Trade names: Alepsal; Barbilixir; Barbita; Barbital; Gardenal;<br />

Luminal (Sanofi-Aventis); Luminaletten; Phenaemal;<br />

Phenobarbitone; Solfoton<br />

Indications: Insomnia, seizures<br />

Category: Anticonvulsant; Barbiturate<br />

Half-life: 2–6 days<br />

Clinically important, potentially hazardous interactions<br />

with: alcohol, anticoagulants, antihistamines, betamethasone,<br />

brompheniramine, buclizine, buprenorphine, chlorpheniramine,<br />

darunavir, dasatinib, delavirdine, dexamethasone, dicumarol,<br />

ethanolamine, fluconazole, flunisolide, fosamprenavir,<br />

hydrocortisone, imatinib, influenza vaccines, lapatinib,<br />

meperidine, methylprednisolone, midazolam, prednisolone,<br />

prednisone, solifenacin, telithromycin, temsirolimus, teniposide,<br />

triamcinolone, warfarin<br />

Reactions<br />

Skin<br />

Acne<br />

(1992): Hesse S+, Ann Dermatol Venereol (French) 119, 655<br />

Acute generalized exanthematous pustulosis (AGEP)<br />

(1996): Wolkenstein P+, Contact Dermatitis 35, 234<br />

Allergic reactions (sic)<br />

(1987): Pigatto PD, Contact Dermatitis 16, 279<br />

Angioedema (

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