Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

PEPPERMINT
Scientific name: Mentha piperita
Family: Labiatae
Trade and other common names: Aludrox; brandy mint;
Colpermin; Enteroplant (peppermint and caraway oils); menthol;
PCC
Category: Analgesic; Carminative; Vasodilator, peripheral
Purported indications and other uses: Dyspepsia, regress
pancreatic, mammary, and liver tumors, irritable bowel
syndrome, colonic spasm, colic, nausea, vomiting, biliary
disorders, common cold, dysmenorrhoea, anxiolytic. Topical:
pain, itching, inflammations, headaches, toothache, pruritus,
urticaria, mosquito repellant. Vapor: bronchial catarrh, fever,
influenza. Flavoring, cosmetics, toothpaste, mouthwash
Half-life: N/A
Clinically important, potentially hazardous interactions
with: cisapride
Reactions
Skin
Adverse effects (sic)
(1999): Madisch A+, Arzneimittelforschung 49(11), 925
(1996): May B+, Arzneimittelforschung 46(12), 1149
Allergic reactions (sic)
Burning (anal)
(1987): Weston CF, Postgrad Med J 63(742), 717
Dermatitis
(2002): Schempp CM+, Hautarzt 53(2), 93
(1994): Wilkinson SM+, Contact Dermatitis 30(1), 42
(1984): Mooller NE+, Acta Pharmacol Toxicol (Copenh)
55(2), 139 (occupational)
Lichenoid eruption
(1995): Morton CA+, Contact Dermatitis 32(5), 281
Perioral dermatitis
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
Rash (sic)
(1997): Liu JH+, J Gastroenterol 32(6), 765
Sensitivity
(2001): Nair B, Int J Toxicol 20, 61
(1995): Morton CA+, Contact Dermatitis 32(5), 281
Mucosal
Burning mouth syndrome
(1995): Morton CA+, Contact Dermatitis 32(5), 281
Cheilitis
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
(1984): Hausen BM, Dtsch Med Wochenschr 109(8), 300
Gingivitis
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
Glossitis
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
Oral ulceration
(1999): Moghadam BK+, Cutis 64(2), 131 (mouthwash abuse)
(1995): Morton CA+, Contact Dermatitis 32(5), 281
Stomatitis
(1995): Rogers SN+, Dent Update 22(1), 36
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
Other
Hypersensitivity
(1995): Sainio EL+, Contact Dermatitis 33(2), 100
Side effects (sic)
(1998): Belanger JT, Altern Med Rev 3(6), 448
(1982): Jaffe G+, JIntMedRes10(6), 437
Toxicity (sic)
(2001): Lazutka JR+, Food Chem Toxicol 39(5), 485
PERFLUTREN
Trade names: Definity (DuPont); Optison (Amersham)
Indications: Echocardiogram imaging
Category: Radiographic contrast medium
Half-life: 1.3 minutes
Reactions
Skin
Diaphoresis (