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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Injection-site calcification<br />

(1991): Magee KL+, Arch Dermatol 127, 1591<br />

(1986): Hertzman A+, J Rheumatol 13, 210<br />

Injection-site fibrosis<br />

Injection-site granuloma<br />

(1982): Menon PA, J Assoc Military Dermatol 2, 65<br />

Injection-site induration<br />

(1996): Bellman B+, Arch Dermatol 132, 1365<br />

(1996): Gillum P, Oklahoma City, OK (from Internet)<br />

(observation)<br />

(1984): Choucair AK+, Neurology 34, 524<br />

(1983): Adams EM+, Arch Intern Med 143, 2203<br />

Injection-site pain<br />

Injection-site pigmentation<br />

(1980): Palestine RF+, JAmAcadDermatol2, 47<br />

Injection-site scleroderma<br />

(2004): Ho J+, Dermatol Surg 30(9), 1252<br />

Lipogranulomas<br />

Panniculitis (chronic)<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford, 212 (passim)<br />

Phlebitis<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford, 212 (passim)<br />

PENTOBARBITAL<br />

Trade names: Medinox Mono; Mintal; Nova Rectal;<br />

Pentobarbitone; Prodromol; Sombutol<br />

Indications: Insomnia, sedation<br />

Category: Barbiturate<br />

Half-life: 15–50 hours<br />

Clinically important, potentially hazardous interactions<br />

with: alcohol, anticoagulants, antihistamines, brompheniramine,<br />

buclizine, chlorpheniramine, dicumarol, ethanolamine, imatinib,<br />

nalbuphine, warfarin<br />

Reactions<br />

Skin<br />

Acne<br />

Angioedema (

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