Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Hypersensitivity (1999): Hsu HL+, TaiwanErhKoIHsuehTsaChih40, 448 (1994): Chan CY+, Am J Gastroenterol 89, 442 Nephrotoxicity (2004): Ohno I+, Nippon Rinsho 62(10), 1919 Serum sickness (1996): Bialy-Golan A+, JAmAcadDermatol35, 732 (passim) PENICILLIN G Trade names: Benzylpenicillin; Crystapen (Britannia); Megacillin; Novopen-G Indications: Anthrax, cellulitis, endocarditis, infections, otitis media, rheumatic fever, respiratory infections, septicemia Category: Antibiotic, penicillin Half-life: 4 hours Clinically important, potentially hazardous interactions with: estrogens, methotrexate, phenindione, probenecid, sulfinpyrazone, warfarin Reactions Skin Angioedema Dermatitis Edema Exfoliative dermatitis Jarisch–Herxheimer reaction Linear IgA dermatosis (1993): Combemale P+, Ann Dermatol Venereol 120(11), 847 Rash (sic) (2003): Zdziarski P, Pol Merkuriusz Lek 14(79), 50 (1996): Markowitz M+, Pediatrics 97(6 Pt 2), 981 Urticaria (2006): Padilla Serrato MT+, Rev Alerg Mex 53(5), 179 Mucosal Tongue black Other Abdominal pain Anaphylactoid reactions/Anaphylaxis (2007): Linares T+, J Investig Allergol Clin Immunol 17(1), 50 (2007): Schafer JA+, Pharmacotherapy 27(4), 542 (1991): Lancet 337(8753), 1308 Chills Embolia cutis medicamentosa (Nicolau syndrome) (2006): Luton K+, Int J Dermatol 45(11), 1326 Fever Hepatotoxicity (2001): Andrade RJ+, Ann Pharmacother 35(6), 783 (1997): Bauer TM+, JHepatol26(2), 429 Hypersensitivity (2003): Scala E+, Allergy 58(5), 439 (1990): Prieto Lopez C+, Allergol Immunopathol (Madr) 18(3), 141 Lipoatrophy (1996): Kayikcioglu A+, JPediatr129(1), 166 Myalgia/Myositis/Myopathy/Myotoxicity Nephrotoxicity (2000): Adlam D+, JInfect40(1), 102 Serum sickness Thrombosis PENICILLIN V Trade names: Abbocillin; Apo-Pen; Diistaquaine V-K; Novapen- VK; Ospen; Penbeta; Phenoxymethylpenicillin Indications: Cellulitis, endocarditis, erysipelas, oral infections, otitis media, rheumatic fever, scarlet fever, tonsillitis Category: Antibiotic, penicillin Half-life: 4 hours Clinically important, potentially hazardous interactions with: estrogens, methotrexate, neomycin, phenindione, probenecid, sulfinpyrazone, warfarin Reactions Skin Angioedema Exanthems (1981): Rockl H, Hautarzt 1981 Sep 32(9), 467 Exfoliative dermatitis Rash (sic) Toxic epidermal necrolysis (2001): Robak E+, JMed32(1–2), 31 (with aminophenazone & paracetamol) Urticaria Vasculitis (1981): Rockl H, Hautarzt 1981 Sep 32(9), 467 Mucosal Tongue black Other Anaphylactoid reactions/Anaphylaxis (1990): Guberman D, Harefuah 118(7), 392 Chills Fever (1985): Drapkin MS+, Arch Surg 120(11), 1321 Hypersensitivity (2003): Schindler C+, Chemotherapy 49(1–2), 90 Nephrotoxicity Serum sickness (1995): Martin J+, NZMedJ108(997), 123 (1990): Heckbert SR+, Am J Epidemiol 132(2), 336 PENTAGASTRIN Trade names: Gastrodiagnost; Peptavlon (Wyeth) Category: Diagnostic aid; Polypeptide hormone Half-life: 10 minutes Reactions Skin Angioedema (1985): Arnved J+, Lancet 2, 1068 Diaphoresis Exanthems Pruritus Purpura (1985): Arnved J+, Lancet 2, 1068 Rash (sic) Urticaria Other Hypersensitivity Injection-site pain PENTAGASTRIN 425

426 PENTAMIDINE PENTAMIDINE Trade names: NebuPent (Astellas); Pentacarinat; Pentam-300 (Astellas) Indications: Pneumocystis carinii infection, trypanosomiasis Category: Antiprotozoal Half-life: 9.1–13.2 hours (IM); 6.5 hours (IV) Clinically important, potentially hazardous interactions with: adefovir, insulin detemir, insulin glulisine, sparfloxacin Note: The rate of adverse side effects is increased in patients with AIDS Reactions Skin Bullous dermatitis Edema Erythema Exanthems (1–15%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 179 (passim) (1990): Leoung GS+, NEnglJMed323, 769 (0.25%) (1990): Monk JP+, Drugs 39, 741 (1990): Soo Hoo GW+, AnnInternMed113, 195 (1–5%) (1989): Berger TG+, AnnInternMed110, 1035 (1988): Leen CLS+, Lancet 2, 1250 (1988): Sattler FR+, AnnInternMed109, 280 (15%) (1987): Goa KL+, Drugs 33, 242 (1.5%) (1984): Gordon FM+, AnnInternMed100, 495 (3%) (1984): Kovacs JA+, AnnInternMed100, 663 (6%) Jarisch–Herxheimer reaction (10%) (1992): Jones RS+, Clin Infect Dis 15, 561 Injection-site ulceration (1991): Bolognia JL, Dermatologica 183, 221 Myalgia/Myositis/Myopathy/Myotoxicity (

426 PENTAMIDINE<br />

PENTAMIDINE<br />

Trade names: NebuPent (Astellas); Pentacarinat; Pentam-300<br />

(Astellas)<br />

Indications: Pneumocystis carinii infection, trypanosomiasis<br />

Category: Antiprotozoal<br />

Half-life: 9.1–13.2 hours (IM); 6.5 hours (IV)<br />

Clinically important, potentially hazardous interactions<br />

with: adefovir, insulin detemir, insulin glulisine, sparfloxacin<br />

Note: The rate of adverse side effects is increased in patients with<br />

AIDS<br />

Reactions<br />

Skin<br />

Bullous dermatitis<br />

Edema<br />

Erythema<br />

Exanthems (1–15%)<br />

(1992): Breathnach SM+, Adverse <strong>Drug</strong> Reactions <strong>and</strong> the Skin<br />

Blackwell, Oxford, 179 (passim)<br />

(1990): Leoung GS+, NEnglJMed323, 769 (0.25%)<br />

(1990): Monk JP+, <strong>Drug</strong>s 39, 741<br />

(1990): Soo Hoo GW+, AnnInternMed113, 195 (1–5%)<br />

(1989): Berger TG+, AnnInternMed110, 1035<br />

(1988): Leen CLS+, Lancet 2, 1250<br />

(1988): Sattler FR+, AnnInternMed109, 280 (15%)<br />

(1987): Goa KL+, <strong>Drug</strong>s 33, 242 (1.5%)<br />

(1984): Gordon FM+, AnnInternMed100, 495 (3%)<br />

(1984): Kovacs JA+, AnnInternMed100, 663 (6%)<br />

Jarisch–Herxheimer reaction (10%)<br />

(1992): Jones RS+, Clin Infect Dis 15, 561<br />

Injection-site ulceration<br />

(1991): Bolognia JL, Dermatologica 183, 221<br />

Myalgia/Myositis/Myopathy/Myotoxicity (

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