Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Hypersensitivity (1999): Hsu HL+, TaiwanErhKoIHsuehTsaChih40, 448 (1994): Chan CY+, Am J Gastroenterol 89, 442 Nephrotoxicity (2004): Ohno I+, Nippon Rinsho 62(10), 1919 Serum sickness (1996): Bialy-Golan A+, JAmAcadDermatol35, 732 (passim) PENICILLIN G Trade names: Benzylpenicillin; Crystapen (Britannia); Megacillin; Novopen-G Indications: Anthrax, cellulitis, endocarditis, infections, otitis media, rheumatic fever, respiratory infections, septicemia Category: Antibiotic, penicillin Half-life: 4 hours Clinically important, potentially hazardous interactions with: estrogens, methotrexate, phenindione, probenecid, sulfinpyrazone, warfarin Reactions Skin Angioedema Dermatitis Edema Exfoliative dermatitis Jarisch–Herxheimer reaction Linear IgA dermatosis (1993): Combemale P+, Ann Dermatol Venereol 120(11), 847 Rash (sic) (2003): Zdziarski P, Pol Merkuriusz Lek 14(79), 50 (1996): Markowitz M+, Pediatrics 97(6 Pt 2), 981 Urticaria (2006): Padilla Serrato MT+, Rev Alerg Mex 53(5), 179 Mucosal Tongue black Other Abdominal pain Anaphylactoid reactions/Anaphylaxis (2007): Linares T+, J Investig Allergol Clin Immunol 17(1), 50 (2007): Schafer JA+, Pharmacotherapy 27(4), 542 (1991): Lancet 337(8753), 1308 Chills Embolia cutis medicamentosa (Nicolau syndrome) (2006): Luton K+, Int J Dermatol 45(11), 1326 Fever Hepatotoxicity (2001): Andrade RJ+, Ann Pharmacother 35(6), 783 (1997): Bauer TM+, JHepatol26(2), 429 Hypersensitivity (2003): Scala E+, Allergy 58(5), 439 (1990): Prieto Lopez C+, Allergol Immunopathol (Madr) 18(3), 141 Lipoatrophy (1996): Kayikcioglu A+, JPediatr129(1), 166 Myalgia/Myositis/Myopathy/Myotoxicity Nephrotoxicity (2000): Adlam D+, JInfect40(1), 102 Serum sickness Thrombosis PENICILLIN V Trade names: Abbocillin; Apo-Pen; Diistaquaine V-K; Novapen- VK; Ospen; Penbeta; Phenoxymethylpenicillin Indications: Cellulitis, endocarditis, erysipelas, oral infections, otitis media, rheumatic fever, scarlet fever, tonsillitis Category: Antibiotic, penicillin Half-life: 4 hours Clinically important, potentially hazardous interactions with: estrogens, methotrexate, neomycin, phenindione, probenecid, sulfinpyrazone, warfarin Reactions Skin Angioedema Exanthems (1981): Rockl H, Hautarzt 1981 Sep 32(9), 467 Exfoliative dermatitis Rash (sic) Toxic epidermal necrolysis (2001): Robak E+, JMed32(1–2), 31 (with aminophenazone & paracetamol) Urticaria Vasculitis (1981): Rockl H, Hautarzt 1981 Sep 32(9), 467 Mucosal Tongue black Other Anaphylactoid reactions/Anaphylaxis (1990): Guberman D, Harefuah 118(7), 392 Chills Fever (1985): Drapkin MS+, Arch Surg 120(11), 1321 Hypersensitivity (2003): Schindler C+, Chemotherapy 49(1–2), 90 Nephrotoxicity Serum sickness (1995): Martin J+, NZMedJ108(997), 123 (1990): Heckbert SR+, Am J Epidemiol 132(2), 336 PENTAGASTRIN Trade names: Gastrodiagnost; Peptavlon (Wyeth) Category: Diagnostic aid; Polypeptide hormone Half-life: 10 minutes Reactions Skin Angioedema (1985): Arnved J+, Lancet 2, 1068 Diaphoresis Exanthems Pruritus Purpura (1985): Arnved J+, Lancet 2, 1068 Rash (sic) Urticaria Other Hypersensitivity Injection-site pain PENTAGASTRIN 425
426 PENTAMIDINE PENTAMIDINE Trade names: NebuPent (Astellas); Pentacarinat; Pentam-300 (Astellas) Indications: Pneumocystis carinii infection, trypanosomiasis Category: Antiprotozoal Half-life: 9.1–13.2 hours (IM); 6.5 hours (IV) Clinically important, potentially hazardous interactions with: adefovir, insulin detemir, insulin glulisine, sparfloxacin Note: The rate of adverse side effects is increased in patients with AIDS Reactions Skin Bullous dermatitis Edema Erythema Exanthems (1–15%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 179 (passim) (1990): Leoung GS+, NEnglJMed323, 769 (0.25%) (1990): Monk JP+, Drugs 39, 741 (1990): Soo Hoo GW+, AnnInternMed113, 195 (1–5%) (1989): Berger TG+, AnnInternMed110, 1035 (1988): Leen CLS+, Lancet 2, 1250 (1988): Sattler FR+, AnnInternMed109, 280 (15%) (1987): Goa KL+, Drugs 33, 242 (1.5%) (1984): Gordon FM+, AnnInternMed100, 495 (3%) (1984): Kovacs JA+, AnnInternMed100, 663 (6%) Jarisch–Herxheimer reaction (10%) (1992): Jones RS+, Clin Infect Dis 15, 561 Injection-site ulceration (1991): Bolognia JL, Dermatologica 183, 221 Myalgia/Myositis/Myopathy/Myotoxicity (
- Page 450 and 451: Erythema multiforme Exanthems (9-16
- Page 452 and 453: Other Anaphylactoid reactions/Anaph
- Page 454 and 455: MUPIROCIN* Trade names: Bactoderm;
- Page 456 and 457: Mucosal Gingivitis (
- Page 458 and 459: (1981): Wolf A, ZHautkr(German) 56,
- Page 460 and 461: (1984): Stern RS+, JAMA 252, 1433 V
- Page 462 and 463: Hair Hair - alopecia (
- Page 464 and 465: NEVIRAPINE Trade name: Viramune (Bo
- Page 466 and 467: (1982): Grunwald Z, Drug Intell Cli
- Page 468 and 469: Urticaria (
- Page 470 and 471: (2000): Rodrigues de Oliveira J+, G
- Page 472 and 473: (2007): Koulaouzidis A+, Ann Hepato
- Page 474 and 475: Vulvovaginal candidiasis (2002): Me
- Page 476 and 477: Mucosal Oral mucosal eruption (1987
- Page 478 and 479: Mucosal Tongue edema Other Anaphyla
- Page 480 and 481: Chills (5-10%) Hypersensitivity (
- Page 482 and 483: OXACILLIN Trade names: Bactocill; B
- Page 484 and 485: Other Anaphylactoid reactions/Anaph
- Page 486 and 487: OXYMORPHONE Synonym: 14-hydroxy-dih
- Page 488 and 489: (2001): Robinson JB+, Gynecol Oncol
- Page 490 and 491: PANCRELIPASE Trade names: Cotazym (
- Page 492 and 493: Exanthems Fixed eruption (1994): Ki
- Page 494 and 495: (2006): Bettoli V+, Acta Derm Vener
- Page 496 and 497: Reactions Skin Adverse effects (sic
- Page 498 and 499: (1981): Hashimoto K+, JAmAcadDermat
- Page 502 and 503: Injection-site calcification (1991)
- Page 504 and 505: PEPPERMINT Scientific name: Mentha
- Page 506 and 507: (1995): Magro CM+, JAmAcadDermatol3
- Page 508 and 509: (1993): Leenutaphong V+, Int J Derm
- Page 510 and 511: PHENYLEPHRINE Trade names: Dionephr
- Page 512 and 513: (1991): Kleier RS, Arch Dermatol 12
- Page 514 and 515: Lymphoproliferative disease (1992):
- Page 516 and 517: (2006): Andersen KE+, Contact Derma
- Page 518 and 519: Oral candidiasis Stomatodynia Vagin
- Page 520 and 521: Reactions Skin Exanthems Petechiae
- Page 522 and 523: Reactions Skin Acne (1-10%) Angioed
- Page 524 and 525: Pruritus (
- Page 526 and 527: PREDNISONE Trade names: Deltasone (
- Page 528 and 529: Other Anticonvulsant hypersensitivi
- Page 530 and 531: Xerosis Mucosal Lip ulceration (198
- Page 532 and 533: (1982): Gall H+, Derm Beruf Umwelt
- Page 534 and 535: (2006): Barkin RL+, Am J Ther 13(6)
- Page 536 and 537: PROTAMINE SULFATE Indications: Hepa
- Page 538 and 539: (1987): Shelley WB+, JAmAcadDermato
- Page 540 and 541: Hypersensitivity Myalgia/Myositis/M
- Page 542 and 543: (1999): Drayton G, Los Angeles, CA
- Page 544 and 545: (1986): Bigby M+, JAMA 256, 3358 (1
- Page 546 and 547: Nails Nails - photo-onycholysis (19
- Page 548 and 549: Hair Hair - alopecia (1-10%) Other
Hypersensitivity<br />
(1999): Hsu HL+, TaiwanErhKoIHsuehTsaChih40, 448<br />
(1994): Chan CY+, Am J Gastroenterol 89, 442<br />
Nephrotoxicity<br />
(2004): Ohno I+, Nippon Rinsho 62(10), 1919<br />
Serum sickness<br />
(1996): Bialy-Golan A+, JAmAcadDermatol35, 732 (passim)<br />
PENICILLIN G<br />
Trade names: Benzylpenicillin; Crystapen (Britannia); Megacillin;<br />
Novopen-G<br />
Indications: Anthrax, cellulitis, endocarditis, infections, otitis<br />
media, rheumatic fever, respiratory infections, septicemia<br />
Category: Antibiotic, penicillin<br />
Half-life: 4 hours<br />
Clinically important, potentially hazardous interactions<br />
with: estrogens, methotrexate, phenindione, probenecid,<br />
sulfinpyrazone, warfarin<br />
Reactions<br />
Skin<br />
Angioedema<br />
Dermatitis<br />
Edema<br />
Exfoliative dermatitis<br />
Jarisch–Herxheimer reaction<br />
Linear IgA dermatosis<br />
(1993): Combemale P+, Ann Dermatol Venereol 120(11), 847<br />
Rash (sic)<br />
(2003): Zdziarski P, Pol Merkuriusz Lek 14(79), 50<br />
(1996): Markowitz M+, Pediatrics 97(6 Pt 2), 981<br />
Urticaria<br />
(2006): Padilla Serrato MT+, Rev Alerg Mex 53(5), 179<br />
Mucosal<br />
Tongue black<br />
Other<br />
Abdominal pain<br />
Anaphylactoid reactions/Anaphylaxis<br />
(2007): Linares T+, J Investig Allergol Clin Immunol 17(1), 50<br />
(2007): Schafer JA+, Pharmacotherapy 27(4), 542<br />
(1991): Lancet 337(8753), 1308<br />
Chills<br />
Embolia cutis medicamentosa (Nicolau syndrome)<br />
(2006): Luton K+, Int J Dermatol 45(11), 1326<br />
Fever<br />
Hepatotoxicity<br />
(2001): Andrade RJ+, Ann Pharmacother 35(6), 783<br />
(1997): Bauer TM+, JHepatol26(2), 429<br />
Hypersensitivity<br />
(2003): Scala E+, Allergy 58(5), 439<br />
(1990): Prieto Lopez C+, Allergol Immunopathol (Madr)<br />
18(3), 141<br />
Lipoatrophy<br />
(1996): Kayikcioglu A+, JPediatr129(1), 166<br />
Myalgia/Myositis/Myopathy/Myotoxicity<br />
Nephrotoxicity<br />
(2000): Adlam D+, JInfect40(1), 102<br />
Serum sickness<br />
Thrombosis<br />
PENICILLIN V<br />
Trade names: Abbocillin; Apo-Pen; Diistaquaine V-K; Novapen-<br />
VK; Ospen; Penbeta; Phenoxymethylpenicillin<br />
Indications: Cellulitis, endocarditis, erysipelas, oral infections,<br />
otitis media, rheumatic fever, scarlet fever, tonsillitis<br />
Category: Antibiotic, penicillin<br />
Half-life: 4 hours<br />
Clinically important, potentially hazardous interactions<br />
with: estrogens, methotrexate, neomycin, phenindione,<br />
probenecid, sulfinpyrazone, warfarin<br />
Reactions<br />
Skin<br />
Angioedema<br />
Exanthems<br />
(1981): Rockl H, Hautarzt 1981 Sep 32(9), 467<br />
Exfoliative dermatitis<br />
Rash (sic)<br />
Toxic epidermal necrolysis<br />
(2001): Robak E+, JMed32(1–2), 31 (with aminophenazone &<br />
paracetamol)<br />
Urticaria<br />
Vasculitis<br />
(1981): Rockl H, Hautarzt 1981 Sep 32(9), 467<br />
Mucosal<br />
Tongue black<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis<br />
(1990): Guberman D, Harefuah 118(7), 392<br />
Chills<br />
Fever<br />
(1985): Drapkin MS+, Arch Surg 120(11), 1321<br />
Hypersensitivity<br />
(2003): Schindler C+, Chemotherapy 49(1–2), 90<br />
Nephrotoxicity<br />
Serum sickness<br />
(1995): Martin J+, NZMedJ108(997), 123<br />
(1990): Heckbert SR+, Am J Epidemiol 132(2), 336<br />
PENTAGASTRIN<br />
Trade names: Gastrodiagnost; Peptavlon (Wyeth)<br />
Category: Diagnostic aid; Polypeptide hormone<br />
Half-life: 10 minutes<br />
Reactions<br />
Skin<br />
Angioedema<br />
(1985): Arnved J+, Lancet 2, 1068<br />
Diaphoresis<br />
Exanthems<br />
Pruritus<br />
Purpura<br />
(1985): Arnved J+, Lancet 2, 1068<br />
Rash (sic)<br />
Urticaria<br />
Other<br />
Hypersensitivity<br />
Injection-site pain<br />
PENTAGASTRIN 425
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