Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

422 PENBUTOLOL
Reactions
Skin
Allergic reactions (sic) (1–5%)
(1985): Marone C+, Curr Med Res Opin 9, 417 (1–5%)
Diaphoresis (1.6%)
Exanthems (1–5%)
(1985): Marone C+, Curr Med Res Opin 9, 417 (1–5%)
Peripheral edema
Pruritus
Psoriasis
Purpura
Rash (sic)
Hair
Hair – alopecia
Nails
Nails – pigmentation
Other
Peyronie’s disease
PENCICLOVIR
Trade name: Denavir (Novartis)
Indications: Herpes simplex (recurrent)
Category: Antiviral
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
Skin
Pigmentation
Pruritus
Rash (sic) (0.1%)
Urticaria
Other
Pain
PENICILLAMINE
Reactions
Trade names: Artamin; D-Penamine; Depen (MedPointe);
Distamine; Kelatin; Pendramine
Indications: Wilson’s disease, rheumatoid arthritis
Category: Antidote; Chelator; Disease-modifying antirheumatic
Half-life: 1.7–3.2 hours
Clinically important, potentially hazardous interactions
with: aluminum hydroxide, antacids, ascorbic acid, bone marrow
suppressants, chloroquine, cytotoxic agents, food, gold,
hydroxychloroquine, iron, magnesium, primaquine, probenecid
Note: For excellent reviews of many of the cutaneous manifestations
caused by penicillamine see (1983): Levy RS+, J Am Acad Dermatol 8,
548 and (1981): Sternlieb I+, J Rheumatol 8 (Suppl 7), 149
Skin
Anetoderma
Atrophy
Reactions
(1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim)
Bullous dermatitis
(1996): Bialy-Golan A+, JAmAcadDermatol35, 732 (passim)
(1982): Fulton RA+, Br J Dermatol 107 (Suppl 22), 95
Bullous pemphigoid
(1998): Weller R+, Ann Pharmacother 32, 1368
(1996): Weller R+, Clin Exp Dermatol 21, 121
(1989): Rasmussen HB+, JCutanPathol16, 154
(1987): Brown MD+, Arch Dermatol 123, 1119
(1986): Gall Y+, Ann Dermatol Venereol (French) 113, 55
Cicatricial pemphigoid
(1985): Shuttleworth D+, Clin Exp Dermatol 10, 392
Cutis laxa
(2005): Rosen LB+, Cutis 76(1), 49
(2004): Pinter R+, Am J Med Genet A 128(3), 294
(2000): Hill VA+, Br J Dermatol 142(3), 560
(2000): Werth V, Dermatology Times 18
(1994): Amichai B+, Isr J Med Sci 30, 667
(1983): Harpey JP+, Lancet 2, 858
(1983): Levy RS+, JAmAcadDermatol8, 548
(1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim)
Cyst
Dermatitis
(1993): De Moor A+, Contact Dermatitis 29, 155 (eyedrops)
(1990): Coenraads PJ+, Contact Dermatitis 23, 371
Dermatomyositis
(1992): Kolsi R+, Rev Rhum Mal Osteoartic (French) 59, 341
(1991): Wilson CL+, Int J Dermatol 30, 148
(1988): Grasedyck K, Z Rheumatol 47 Suppl 1, 17
(1987): Carroll CG+, J Rheumatol 14, 995
(1983): Doyle DR+, AnnInternMed98, 327
(1983): Levy RS+, JAmAcadDermatol8, 548
(1983): Lund HI+, Scand J Rheumatol 12, 350
(1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim)
(1981): Major GA, JRSocMed74, 393
(1980): Wojnarowska F, JRSocMed73, 884
Edema of lip (1–10%)
(1999): Hsu HL+, TaiwanErhKoIHsuehTsaChih40, 448 (lip)
Ehlers–Danlos syndrome
(1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim)
(1982): Yung CW+, JAmAcadDermatol6, 317 (passim)
Elastosis perforans serpiginosa
(2005): Becuwe C+, Dermatology 210(1), 60
(2005): Rath N+, Indian J Dermatol Venereol Leprol 71(3), 182
(2005): Rosen LB+, Cutis 76(1), 49
(2002): Deguti MM+, Am J Gastroenterol 97(8), 2153
(2001): Danby FW, Manchester, NH (from Internet)
(observation)
(2000): Hill VA+, Br J Dermatol 142, 560
(2000): Werth V, Dermatology Times 18
(1997): Iozumi K+, JDermatol24(7), 458
(1994): Amichai B+, Isr J Med Sci 30, 667
(1994): Ratnavel RC+, Dermatology 189, 81
(1994): Wilhelm KP+, Hautarzt (German) 45, 45
(1989): Sahn EE+, JAmAcadDermatol20, 279
(1989): Sahn EE+, JAmAcadDermatol20(5 Pt 2), 979
(1988): Grasedyck K, Z Rheumatol 47 Suppl 1, 17
(1988): van Joost T+, Ned Tijdschr Geneeskd (Dutch) 132, 501
(1986): Price RG+, Am J Dermatopathol 8, 314
(1985): Meyrick-Thomas RHM+, Clin Exp Dermatol 10, 386
(1984): Venencie PY+, Ann Med Interne (Paris) (French) 135, 642
(1983): Levy RS+, JAmAcadDermatol8, 548
(1983): Rosenblum GA, JAmAcadDermatol8, 718
(1982): Bailin PL+, Clin Rheum Dis 8, 493 (passim)
(1982): Essigman WK, Ann Rheum Dis 41, 617
(1982): Gloor M+, Hautarzt (German) 33, 291
(1982): Raymond JL+, JCutanPathol9, 352
(1981): Bardach H+, Wien Klin Wochenschr (German) 93, 117
(1981): Gebhart W+, Am J Dermatopathol 3(1), 33