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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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420 PEGASPARGASE<br />

PEGASPARGASE<br />

Synonym: NSC-644954<br />

Trade name: Oncaspar (Enzon)<br />

Indications: Acute lymphoblastic leukemia<br />

Category: Antineoplastic<br />

Half-life: 5.7 days<br />

Clinically important, potentially hazardous interactions<br />

with: N/A<br />

Reactions<br />

Skin<br />

Allergic reactions (>5%)<br />

(2003): Agrawal NR+, Cancer 98(1), 94<br />

(2003): Graham ML, Adv <strong>Drug</strong> Deliv Rev 55(10), 1293<br />

(1998): Graham ML+, Bone Marrow Transplant 21(9), 879<br />

Angioedema (1–5%)<br />

Diaphoresis<br />

Edema (>5%)<br />

Erythema (

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