Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Chills (5–10%) Hypersensitivity (
406 ORAL CONTRACEPTIVES Mucosal Gingival hyperplasia/hypertrophy Oral pigmentation (1980): Hertz RS+, J Am Dent Assoc 100, 713 (gingival) Hair Hair – alopecia (1989): Burke KE, Postgrad Med 85, 52 (1987): Kovacs G+, Australasian J Dermatol 28, 86 (1982): Hauser GA+, Int J Tissue React 4, 159 (1981): Scholz C+, Zentralbl Gynakol (German) 103, 1158 Hair – alopecia areata Hair – hirsutism (1994): Burdova M+, Ceska Gynekol (Czech) 59, 62 (1987): Kovacs G+, Australasian J Dermatol 28, 86 (1981): Scholz C+, Zentralbl Gynakol (German) 103, 1158 Nails Nails – onycholysis Other Application-site reactions (sic) (92%) (2002): Sibai BM+, Fertil Steril 77(2 Suppl 2), S19 (patch) (92%) Candidiasis (1983): Lebherz TB+, Clin Ther 5, 409 Porphyria cutanea tarda (2001): Emri G+, Orv Hetil 142(47), 2635 (1992): McKenna KE+, Br J Dermatol 127, 401 (1983): Doss M, Dtsch Med Wochenschr (German) 108, 1857 (1983): Zaumseil RP+, Zentralbl Gynakol (German) 105, 527 (1982): Zaumseil RP+, ZGesamteInMed(German) 37, 703 (1981): Fiedler H+, Dermatol Monatsschr (German) 167, 481 Porphyria variegata Pseudoporphyria (2003): Silver EA+, Arch Dermatol 139, 227 Thrombophlebitis (1985): Taylor F, Aust Fam Physician 14(8), 744 ORLISTAT Trade name: Xenical (Roche) Indications: Obesity, weight reduction Category: Lipase inhibitor Half-life: 1–2 hours Clinically important, potentially hazardous interactions with: cyclosporine, warfarin Reactions Skin Dermatitis Lichenoid eruption (2006): Sergeant A+, Br J Dermatol 154(5), 1020 Nodular eruption Rash (sic) (4.3%) Xerosis Mucosal Gingivitis (4.1%) Vaginitis (3.8%) (2006): Acharya NV+, Int J Obes (Lond) 30(11), 1645 Other Abdominal pain (2006): Acharya NV+, Int J Obes (Lond) 30(11), 1645 Hepatotoxicity (2006): Umemura T+, Am J Med 119(8), e7 Myalgia/Myositis/Myopathy/Myotoxicity (4.2%) Tendinopathy/Tendon rupture ORPHENADRINE Trade names: Banflex (Forest); Biorfen; Biorphen; Disipal; Distalene; Flexojet; Flexon; Myolin; Norflex (3M); Norgesic; Opheryl; Orfenace; Prolongatum Indications: Painful musculoskeletal conditions Category: Central muscle relaxant; Muscarinic antagonist Half-life: 14 hours Reactions Skin Exanthems Fixed eruption (1998): Mahboob A+, Int J Dermatol 37, 833 Pigmentation Pruritus Rash (sic) (1–10%) Urticaria Mucosal Xerostomia Other Anaphylactoid reactions/Anaphylaxis Embolia cutis medicamentosa (Nicolau syndrome) Hypersensitivity OSELTAMIVIR Trade name: Tamiflu (Roche) Indications: Influenza infection Category: Antiviral; Neuraminidase inhibitor Half-life: 6–10 hours Reactions Skin Rash (sic) (2005): Kaji M+, J Infect Chemother 11(1), 41 (2003): Li L+, Chin Med J (Engl) 116(1), 44 Toxic epidermal necrolysis (2006): Prescrire Int 15(85), 182 Other Cough (2002): Bowles SK+, JAmGeriatrSoc50(4), 608 Death (2006): Prescrire Int 15(85), 182 Myalgia/Myositis/Myopathy/Myotoxicity (2001): McNicholl IR+, Ann Pharmacother 35(1), 57 Neurotoxicity (2006): Prescrire Int 15(85), 182 Upper respiratory infection (2001): McNicholl IR+, Ann Pharmacother 35(1), 57
- Page 430 and 431: (1995): Vogt T+, Br J Dermatol 133,
- Page 432 and 433: Mucosal Aphthous stomatitis (2003):
- Page 434 and 435: (1987): Norris PG+, Clin Exp Dermat
- Page 436 and 437: (1998): Corazza M+, Contact Dermati
- Page 438 and 439: METOCLOPRAMIDE Trade names: Apo-Met
- Page 440 and 441: Oral ulceration Stomatitis (1987):
- Page 442 and 443: Reactions Skin Erythema multiforme
- Page 444 and 445: (1996): Carrington PR, Little Rock,
- Page 446 and 447: (2003): Abe M+, Intern Med 42(1), 4
- Page 448 and 449: Other Abdominal pain (2006): Preutt
- Page 450 and 451: Erythema multiforme Exanthems (9-16
- Page 452 and 453: Other Anaphylactoid reactions/Anaph
- Page 454 and 455: MUPIROCIN* Trade names: Bactoderm;
- Page 456 and 457: Mucosal Gingivitis (
- Page 458 and 459: (1981): Wolf A, ZHautkr(German) 56,
- Page 460 and 461: (1984): Stern RS+, JAMA 252, 1433 V
- Page 462 and 463: Hair Hair - alopecia (
- Page 464 and 465: NEVIRAPINE Trade name: Viramune (Bo
- Page 466 and 467: (1982): Grunwald Z, Drug Intell Cli
- Page 468 and 469: Urticaria (
- Page 470 and 471: (2000): Rodrigues de Oliveira J+, G
- Page 472 and 473: (2007): Koulaouzidis A+, Ann Hepato
- Page 474 and 475: Vulvovaginal candidiasis (2002): Me
- Page 476 and 477: Mucosal Oral mucosal eruption (1987
- Page 478 and 479: Mucosal Tongue edema Other Anaphyla
- Page 482 and 483: OXACILLIN Trade names: Bactocill; B
- Page 484 and 485: Other Anaphylactoid reactions/Anaph
- Page 486 and 487: OXYMORPHONE Synonym: 14-hydroxy-dih
- Page 488 and 489: (2001): Robinson JB+, Gynecol Oncol
- Page 490 and 491: PANCRELIPASE Trade names: Cotazym (
- Page 492 and 493: Exanthems Fixed eruption (1994): Ki
- Page 494 and 495: (2006): Bettoli V+, Acta Derm Vener
- Page 496 and 497: Reactions Skin Adverse effects (sic
- Page 498 and 499: (1981): Hashimoto K+, JAmAcadDermat
- Page 500 and 501: Hypersensitivity (1999): Hsu HL+, T
- Page 502 and 503: Injection-site calcification (1991)
- Page 504 and 505: PEPPERMINT Scientific name: Mentha
- Page 506 and 507: (1995): Magro CM+, JAmAcadDermatol3
- Page 508 and 509: (1993): Leenutaphong V+, Int J Derm
- Page 510 and 511: PHENYLEPHRINE Trade names: Dionephr
- Page 512 and 513: (1991): Kleier RS, Arch Dermatol 12
- Page 514 and 515: Lymphoproliferative disease (1992):
- Page 516 and 517: (2006): Andersen KE+, Contact Derma
- Page 518 and 519: Oral candidiasis Stomatodynia Vagin
- Page 520 and 521: Reactions Skin Exanthems Petechiae
- Page 522 and 523: Reactions Skin Acne (1-10%) Angioed
- Page 524 and 525: Pruritus (
- Page 526 and 527: PREDNISONE Trade names: Deltasone (
- Page 528 and 529: Other Anticonvulsant hypersensitivi
406 ORAL CONTRACEPTIVES<br />
Mucosal<br />
Gingival hyperplasia/hypertrophy<br />
Oral pigmentation<br />
(1980): Hertz RS+, J Am Dent Assoc 100, 713 (gingival)<br />
Hair<br />
Hair – alopecia<br />
(1989): Burke KE, Postgrad Med 85, 52<br />
(1987): Kovacs G+, Australasian J Dermatol 28, 86<br />
(1982): Hauser GA+, Int J Tissue React 4, 159<br />
(1981): Scholz C+, Zentralbl Gynakol (German) 103, 1158<br />
Hair – alopecia areata<br />
Hair – hirsutism<br />
(1994): Burdova M+, Ceska Gynekol (Czech) 59, 62<br />
(1987): Kovacs G+, Australasian J Dermatol 28, 86<br />
(1981): Scholz C+, Zentralbl Gynakol (German) 103, 1158<br />
Nails<br />
Nails – onycholysis<br />
Other<br />
Application-site reactions (sic) (92%)<br />
(2002): Sibai BM+, Fertil Steril 77(2 Suppl 2), S19 (patch) (92%)<br />
C<strong>and</strong>idiasis<br />
(1983): Lebherz TB+, Clin Ther 5, 409<br />
Porphyria cutanea tarda<br />
(2001): Emri G+, Orv Hetil 142(47), 2635<br />
(1992): McKenna KE+, Br J Dermatol 127, 401<br />
(1983): Doss M, Dtsch Med Wochenschr (German) 108, 1857<br />
(1983): Zaumseil RP+, Zentralbl Gynakol (German) 105, 527<br />
(1982): Zaumseil RP+, ZGesamteInMed(German) 37, 703<br />
(1981): Fiedler H+, Dermatol Monatsschr (German) 167, 481<br />
Porphyria variegata<br />
Pseudoporphyria<br />
(2003): Silver EA+, Arch Dermatol 139, 227<br />
Thrombophlebitis<br />
(1985): Taylor F, Aust Fam Physician 14(8), 744<br />
ORLISTAT<br />
Trade name: Xenical (Roche)<br />
Indications: Obesity, weight reduction<br />
Category: Lipase inhibitor<br />
Half-life: 1–2 hours<br />
Clinically important, potentially hazardous interactions<br />
with: cyclosporine, warfarin<br />
Reactions<br />
Skin<br />
Dermatitis<br />
Lichenoid eruption<br />
(2006): Sergeant A+, Br J Dermatol 154(5), 1020<br />
Nodular eruption<br />
Rash (sic) (4.3%)<br />
Xerosis<br />
Mucosal<br />
Gingivitis (4.1%)<br />
Vaginitis (3.8%)<br />
(2006): Acharya NV+, Int J Obes (Lond) 30(11), 1645<br />
Other<br />
Abdominal pain<br />
(2006): Acharya NV+, Int J Obes (Lond) 30(11), 1645<br />
Hepatotoxicity<br />
(2006): Umemura T+, Am J Med 119(8), e7<br />
Myalgia/Myositis/Myopathy/Myotoxicity (4.2%)<br />
Tendinopathy/Tendon rupture<br />
ORPHENADRINE<br />
Trade names: Banflex (Forest); Biorfen; Biorphen; Disipal;<br />
Distalene; Flexojet; Flexon; Myolin; Norflex (3M); Norgesic;<br />
Opheryl; Orfenace; Prolongatum<br />
Indications: Painful musculoskeletal conditions<br />
Category: Central muscle relaxant; Muscarinic antagonist<br />
Half-life: 14 hours<br />
Reactions<br />
Skin<br />
Exanthems<br />
Fixed eruption<br />
(1998): Mahboob A+, Int J Dermatol 37, 833<br />
Pigmentation<br />
Pruritus<br />
Rash (sic) (1–10%)<br />
Urticaria<br />
Mucosal<br />
Xerostomia<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis<br />
Embolia cutis medicamentosa (Nicolau syndrome)<br />
Hypersensitivity<br />
OSELTAMIVIR<br />
Trade name: Tamiflu (Roche)<br />
Indications: Influenza infection<br />
Category: Antiviral; Neuraminidase inhibitor<br />
Half-life: 6–10 hours<br />
Reactions<br />
Skin<br />
Rash (sic)<br />
(2005): Kaji M+, J Infect Chemother 11(1), 41<br />
(2003): Li L+, Chin Med J (Engl) 116(1), 44<br />
Toxic epidermal necrolysis<br />
(2006): Prescrire Int 15(85), 182<br />
Other<br />
Cough<br />
(2002): Bowles SK+, JAmGeriatrSoc50(4), 608<br />
Death<br />
(2006): Prescrire Int 15(85), 182<br />
Myalgia/Myositis/Myopathy/Myotoxicity<br />
(2001): McNicholl IR+, Ann Pharmacother 35(1), 57<br />
Neurotoxicity<br />
(2006): Prescrire Int 15(85), 182<br />
Upper respiratory infection<br />
(2001): McNicholl IR+, Ann Pharmacother 35(1), 57
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