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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Mucosal<br />

Tongue edema<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis (45%)<br />

(2007): Price KS+, Allergy Asthma Proc 28(3), 313<br />

(2006): Dreyfus DH+, Ann Allergy Asthma Immunol 96(4), 624<br />

(2006): Price K, American Academy Allergy Asthma Immunology<br />

(poster)<br />

(2005): Lanier BQ, Allergy Asthma Proc 26(6), 435<br />

Hypersensitivity<br />

Injection-site burning<br />

Injection-site erythema<br />

Injection-site induration<br />

Injection-site pruritus<br />

Injection-site purpura<br />

Injection-site reactions (sic) (45%)<br />

(2004): Bang LM+, Bio<strong>Drug</strong>s 18(6), 415<br />

(2004): Bang LM+, Treat Respir Med 3(3), 183<br />

Injection-site urticaria<br />

Pain (7%)<br />

Upper respiratory infection (20%)<br />

(2004): Bang LM+, Bio<strong>Drug</strong>s 18(6), 415<br />

(2004): Bang LM+, Treat Respir Med 3(3), 183<br />

(2003): Berger W+, Ann Allergy Asthma Immunol 91(2), 182<br />

OMEGA-3 FATTY ACIDS<br />

Scientific names: docosahexaenoic acid (DHA); eicosapentaenoic<br />

acid (EPA); Omega-3 fatty acids<br />

Family: N/A<br />

Category: Anti-inflammatory; Lipid regulator<br />

Purported indications <strong>and</strong> other uses: Albuminuria, anorexia<br />

nervosa, hypertension, lupus erythematosus, macular<br />

degeneration, osteoarthritis, otitis media, psoriasis<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: N/A<br />

Reactions<br />

Skin<br />

Malignant melanoma<br />

(1997): Veierod MB+, Int J Cancer 71(4), 600<br />

Rash (sic)<br />

Eyes<br />

Glaucoma<br />

(2004): Kang JH+, Am J Clin Nutr 79(5), 755<br />

Other<br />

Abdominal pain<br />

Hypersensitivity<br />

Lymphoid hyperplasia<br />

(1988): Ogden P+, AnnInternMed109(10), 843<br />

Note: More than 25 mL or 3 g per day can increase the risk of<br />

bleeding. Fish oils contain a significant amount of vitamins A <strong>and</strong> D<br />

<strong>and</strong> high doses may be toxic.<br />

OMEPRAZOLE<br />

Trade names: Antra; Audazol; Gastroloc; Inhibitron; Logastric;<br />

Losec; Mopral; Omed; Ozoken; Parizac; Prilosec (AstraZeneca);<br />

Ulsen<br />

Indications: Duodenal ulcer, Gastroesophageal Reflux Disease<br />

(GERD)<br />

Category: Proton pump inhibitor<br />

Half-life: 0.5–1 hour<br />

Clinically important, potentially hazardous interactions<br />

with: eucalyptus, methotrexate, prednisone<br />

Reactions<br />

OMEPRAZOLE 403<br />

Skin<br />

Angioedema (

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