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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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382 NAFARELIN<br />

Urticaria (1–10%)<br />

Mucosal<br />

Vaginitis<br />

Hair<br />

Hair – hirsutism (1–10%)<br />

Other<br />

Gynecomastia (10%)<br />

(1997): Bergqvist A+, Gynecol Endocrinol 11(3), 187<br />

Hypersensitivity (0.2%)<br />

Myalgia/Myositis/Myopathy/Myotoxicity (>10%)<br />

NAFCILLIN<br />

Trade names: Nafcil (Merz); Vigopen<br />

Indications: Various infections caused by susceptible organisms<br />

Category: Antibiotic, penicillin<br />

Half-life: 0.5–1.5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticoagulants, cyclosporine, demeclocycline, doxycycline,<br />

imipenem/cilastatin, methotrexate, minocycline, oxytetracycline,<br />

tetracycline, warfarin<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

(1994): Pleasants RA+, Chest 106, 1124 (in patients with cystic<br />

fibrosis)<br />

Angioedema<br />

Bullous dermatitis<br />

Erythema multiforme<br />

Exanthems (10%)<br />

Exfoliative dermatitis<br />

Hematomas<br />

Jarisch–Herxheimer reaction<br />

Jaundice<br />

(1994): Schuman R+, Am J Gastroenterol 89(6), 952<br />

Lupus erythematosus<br />

(2004): Blazes DL+, Rheumatol Int 24(4), 242<br />

Necrosis<br />

(1980): Tilden SJ+, Am J Dis Child 134(11), 1046<br />

Pruritus<br />

Rash (sic) (1–32%)<br />

(2002): Maraqa NF+, Clin Infect Dis 34(1), 50 (32%)<br />

Stevens–Johnson syndrome<br />

Toxic epidermal necrolysis<br />

Urticaria<br />

Vasculitis<br />

Mucosal<br />

Glossitis<br />

Glossodynia<br />

Oral c<strong>and</strong>idiasis<br />

Stomatitis<br />

Stomatodynia<br />

Tongue black<br />

Vaginitis<br />

Xerostomia<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Hepatotoxicity<br />

(1996): Presti ME+, Dig Dis Sci 41(1), 180<br />

(1993): Mazuryk H+, Am J Gastroenterol 88(11), 1960<br />

(1992): Lestico MR+, Ann Pharmacother 26(7–8), 985<br />

Hypersensitivity (

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