Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

380 MYCOPHENOLATE
(2005): Prokopenko EI+, Ter Arkh 77(1), 67
(2005): Shipkova M+, Expert Opin Drug Metab Toxicol 1(3), 505
(2002): Bernabeu-Wittel M+, Eur J Clin Microbiol Infect Dis
21(3), 173
Myalgia/Myositis/Myopathy/Myotoxicity
(2005): Galindo M+, J Rheumatol 32(1), 188
(2005): Shipkova M+, Expert Opin Drug Metab Toxicol 1(3), 505
(2002): Greiner K+, Ophthalmologe 99(9), 691
Thrombophlebitis (1–10%)
MYRRH
Scientific names: Commiphora abyssinica; Commiphora erythraea;
Commiphora habessinica; Commiphora kataf; Commiphora
madagascariensis; Commiphora molmol; Commiphora myrrh
Family: Burseraceae
Trade and other common names: Bal; Balsamodendron;
Bdellium; Bol; Bola; Didin; Didthin; Heerabol; Mirazid; Mirra;
Morr
Category: Anti-inflammatory; Antihelmintic
Purported indications and other uses: Fascioliasis,
schistosomiasis, ulcers, eczema, catarrh, amenorrhea, gum
disease, aphthous stomatitis
Half-life: N/A
Clinically important, potentially hazardous interactions
with: methimazole, propylthiouracil
Reactions
Skin
Dermatitis
(2000): Anderson C+, Phytother Res 14(6), 452
(1999): Gallo R+, Contact Dermatitis 41(4), 230
(1998): Al-Suwaidan SN+, Contact Dermatitis 39(3), 137
(1993): Lee TY+, Contact Dermatitis 28(2), 89
(1993): Lee TY+, Contact Dermatitis 29(5), 279
Pruritus (0.5%)
(2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (0.5%)
Side effects (sic)
(2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (mild &
transient)
Other
Abdominal pain (2%)
(2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (2%)
Rhabdomyolysis
(2004): Bianchi A+, Ann Pharmacother 38(7-8), 1222
NABILONE
Trade name: Cesamet (Valeant)
Indications: Nausea and vomiting
Category: Cannabinoid
Half-life: ~2 hours
Clinically important, potentially hazardous interactions
with: CNS depressants
Reactions
Mucosal
Xerostomia
(2006): Berlach DM+, Pain Med 7(1), 25
(1986): Pomeroy M+, Cancer Chemother Pharmacol 17(3), 285
(1983): George M+, Biomed Pharmacother 37(1), 24
Eyes
Vision blurred
(1985): Ward A+, Drugs 30(2), 127
Other
Abdominal pain
NABUMETONE
Trade names: Arthaxan; Consolan; Nabuser; Prodac; Relafen
(GSK); Relif; Relifex; Unimetone
Indications: Arthritis
Category: Non-steroidal anti-inflammatory
Half-life: 22.5–30 hours
Clinically important, potentially hazardous interactions
with: methotrexate
Reactions
Skin
Acne (