Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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MUPIROCIN* Trade names: Bactoderm; Bactroban (GSK); Eismycin; Mupiderm Indications: Secondarily infected traumatic skin lesions due to susceptible strains of Staphylococcus aureus and Streptococcus pyogenes, impetigo Category: Antibiotic, topical Half-life: N/A Clinically important, potentially hazardous interactions with: None *Note: Also known as pseudomonic acid, mupirocin is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens Reactions Skin Allergic reactions (sic) (1999): Mylotte JM+, Infect Control Hosp Epidemiol 20(11), 741 (intranasal) (1995): Eedy DJ, Contact Dermatitis 32(4), 240 Burning (1997): Bertino JS, Am J Health Sys Pharm 54(19), 2185 (of nose) (intranasal) Cellulitis (

380 MYCOPHENOLATE (2005): Prokopenko EI+, Ter Arkh 77(1), 67 (2005): Shipkova M+, Expert Opin Drug Metab Toxicol 1(3), 505 (2002): Bernabeu-Wittel M+, Eur J Clin Microbiol Infect Dis 21(3), 173 Myalgia/Myositis/Myopathy/Myotoxicity (2005): Galindo M+, J Rheumatol 32(1), 188 (2005): Shipkova M+, Expert Opin Drug Metab Toxicol 1(3), 505 (2002): Greiner K+, Ophthalmologe 99(9), 691 Thrombophlebitis (1–10%) MYRRH Scientific names: Commiphora abyssinica; Commiphora erythraea; Commiphora habessinica; Commiphora kataf; Commiphora madagascariensis; Commiphora molmol; Commiphora myrrh Family: Burseraceae Trade and other common names: Bal; Balsamodendron; Bdellium; Bol; Bola; Didin; Didthin; Heerabol; Mirazid; Mirra; Morr Category: Anti-inflammatory; Antihelmintic Purported indications and other uses: Fascioliasis, schistosomiasis, ulcers, eczema, catarrh, amenorrhea, gum disease, aphthous stomatitis Half-life: N/A Clinically important, potentially hazardous interactions with: methimazole, propylthiouracil Reactions Skin Dermatitis (2000): Anderson C+, Phytother Res 14(6), 452 (1999): Gallo R+, Contact Dermatitis 41(4), 230 (1998): Al-Suwaidan SN+, Contact Dermatitis 39(3), 137 (1993): Lee TY+, Contact Dermatitis 28(2), 89 (1993): Lee TY+, Contact Dermatitis 29(5), 279 Pruritus (0.5%) (2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (0.5%) Side effects (sic) (2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (mild & transient) Other Abdominal pain (2%) (2001): Sheir Z+, Am J Trop Med Hyg 65(6), 700 (2%) Rhabdomyolysis (2004): Bianchi A+, Ann Pharmacother 38(7-8), 1222 NABILONE Trade name: Cesamet (Valeant) Indications: Nausea and vomiting Category: Cannabinoid Half-life: ~2 hours Clinically important, potentially hazardous interactions with: CNS depressants Reactions Mucosal Xerostomia (2006): Berlach DM+, Pain Med 7(1), 25 (1986): Pomeroy M+, Cancer Chemother Pharmacol 17(3), 285 (1983): George M+, Biomed Pharmacother 37(1), 24 Eyes Vision blurred (1985): Ward A+, Drugs 30(2), 127 Other Abdominal pain NABUMETONE Trade names: Arthaxan; Consolan; Nabuser; Prodac; Relafen (GSK); Relif; Relifex; Unimetone Indications: Arthritis Category: Non-steroidal anti-inflammatory Half-life: 22.5–30 hours Clinically important, potentially hazardous interactions with: methotrexate Reactions Skin Acne (

MUPIROCIN*<br />

Trade names: Bactoderm; Bactroban (GSK); Eismycin;<br />

Mupiderm<br />

Indications: Secondarily infected traumatic skin lesions due to<br />

susceptible strains of Staphylococcus aureus <strong>and</strong> Streptococcus<br />

pyogenes, impetigo<br />

Category: Antibiotic, topical<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

*Note: Also known as pseudomonic acid, mupirocin is an antibacterial<br />

agent produced by fermentation using the organism Pseudomonas<br />

fluorescens<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

(1999): Mylotte JM+, Infect Control Hosp Epidemiol 20(11), 741<br />

(intranasal)<br />

(1995): Eedy DJ, Contact Dermatitis 32(4), 240<br />

Burning<br />

(1997): Bertino JS, Am J Health Sys Pharm 54(19), 2185 (of nose)<br />

(intranasal)<br />

Cellulitis (

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