Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

378 MORPHINE
Reactions
Skin
Acute generalized exanthematous pustulosis (AGEP)
(2006): Kardaun SH+, JAmAcadDermatol55(2), S21
Diaphoresis
(2003): Sayyid SS+, RegAnesthPainMed28(2), 140
Edema
Exanthems
Pallor
Peripheral edema
Pruritus (5–65%)
(2006): Chang KY+, Acta Anaesthesiol Taiwan 44(3), 153 (24%)
(2006): Galea M, Br J Anaesth 97(3), 426
(2006): Raffaeli W+, Eur J Anaesthesiol 23(7), 605
(2005): Gambling D+, Anesth Analg 100(4), 1065
(2005): Greenwald PW+, Am J Emerg Med 23(1), 35 (4%)
(2005): Sfeir S+, Middle East J Anesthesiol 18(1), 133
(2003): Charuluxananan S+, Anesth Analg 96(6), 1789
(2003): Duale C+, Br J Anaesth 91(5), 690
(2003): Murphy PM+, Anesth Analg 97(6), 1709
(2003): Sayyid SS+, RegAnesthPainMed28(2), 140
(2002): Nakata K+, J Clin Anesth 14(2), 121
(2001): Charuluxananan S+, Anesth Analg 93(1), 162
(2001): Matsuda M+, Masui 50(10), 1096
(2001): Mercadante S+, Support Care Cancer 9(6), 467
(2001): Sakai T+, Can J Anaesth 48(8), 831
(2001): Subramaniam K+, J Clin Anesth 13(5), 339 (with
ketamine)
(2000): Gunter JB+, Paediatr Anaesth 10, 167
(2000): Yeh HM+, Anesth Analg 91, 172
(1999): Joshi GP+, Anesthesiology 90(4), 1007
(1998): Thangaturai D+, Anaesthesia 43, 1055 (62%)
(1992): Cohen SE+, Anesth Analg 75(5), 747
(1988): Gustafson LL+, Drugs 35, 597 (5–10%)
(1986): Attia J+, Anesthesiology 65, 590 (20%)
Psoriasis
Rash (sic)
Mucosal
Xerostomia (>10%)
(2004): Andersen G+, Eur J Pain 8(3), 263
(2002): Andersen G+, Palliat Med 16(2), 107
(1989): White JD+, BMJ 298, 1222 (75%)
Other
Death
(2006): Lotsch J+, Clin Pharmacokinet 45(11), 1051
(2005): Reith D+, NZMedJ118(1209), U1293 (33 cases)
(2002): Byard RW, JForensicSci47(1), 202
Gynecomastia
Injection-site pain (>10%)
Rhabdomyolysis
(2002): Molia A+, Therapie 57(6), 595
(1985): Blain PG+, Hum Toxicol 4(1), 71
MOXIFLOXACIN
Trade name: Avelox (Schering)
Indications: Various infections caused by susceptible organisms
Category: Antibiotic, quinolone
Half-life: 12 hours
Clinically important, potentially hazardous interactions
with: amiodarone, arsenic, bepridil, bretylium, disopyramide,
erythromycin, phenothiazines, procainamide, quinidine, sotalol,
tricyclic antidepressants, zinc, ziprasidone
Reactions
Skin
Allergic reactions (sic)
Bullous dermatitis
(2004): Nori S+, Arch Dermatol 140(12), 1537
Burning
Desquamation (lips)
(2004): Nori S+, Arch Dermatol 140(12), 1537
Diaphoresis (