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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Erythema multiforme<br />

Exanthems (9–16%)<br />

Pigmentation (16%)<br />

Pruritus<br />

Rash (sic) (15%)<br />

Side effects (sic) (13–17%)<br />

Urticaria<br />

Vasculitis (15%)<br />

Necrosis<br />

Petechiae (>10%)<br />

Pigmentation (bluish)<br />

Purpura (>10%)<br />

Rash (sic) (66%)<br />

(2004): Cohen BA+, Neurology 63(12 Suppl 6), S28<br />

MODAFINIL<br />

Trade names: Alertec; Provigil (Cephalon)<br />

Indications: Narcolepsy<br />

Category: Analeptic; CNS stimulant<br />

Half-life: ~15 hours<br />

Clinically important, potentially hazardous interactions<br />

with: oral contraceptives<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (>1%)<br />

Diaphoresis (>1%)<br />

Edema (>1%)<br />

Erythema<br />

Herpes simplex (1%)<br />

Pruritus (>1%)<br />

Psoriasis (>1%)<br />

Rash (sic) (>1%)<br />

Xerosis (1%)<br />

Mucosal<br />

Gingivitis (1%)<br />

Oral ulceration (1%)<br />

Sialorrhea<br />

Xerostomia (5%)<br />

Other<br />

Chills (2%)<br />

Hot flashes<br />

Myalgia/Myositis/Myopathy/Myotoxicity (>1%)<br />

MOEXIPRIL<br />

Trade names: Uniretic (Schwarz); Univasc (Schwarz)<br />

Indications: Hypertension<br />

Category: Angiotensin-converting enzyme inhibitor<br />

Half-life: 1 hour<br />

Clinically important, potentially hazardous interactions<br />

with: amiloride, spironolactone, triamterene<br />

Uniretic is moexipril <strong>and</strong> hydrochlorothiazide<br />

Reactions<br />

MOEXIPRIL 375<br />

Skin<br />

Adverse effects (sic)<br />

(1994): White WB+, JHumanHypertens8, 917<br />

Angioedema (

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