Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Other
Abdominal pain
(2006): Preutthipan S+, Fertil Steril 86(4), 990
(2006): Ruangchainikhom W+, J Med Assoc Thai 89(7), 928
(2006): Stojnic J+, Vojnosanit Pregl 63(6), 558
(2002): Tang OS+, Hum Reprod 17(7), 1738 (89%) (with
mifepristone)
Anaphylactoid reactions/Anaphylaxis
(2002): Meuleman C+, Arch Mal Coeur Vaiss 95(12), 1230 (with
diclofenac)
Chills
(2006): Derman RJ+, Lancet 368(9543), 1248
(2002): Tang OS+, Hum Reprod 17(7), 1738 (38%) (with
mifepristone)
Fever
(2006): Derman RJ+, Lancet 368(9543), 1248
(2006): Preutthipan S+, Fertil Steril 86(4), 990 (7%)
(2006): Ruangchainikhom W+, J Med Assoc Thai 89(7), 928
(2006): Stojnic J+, Vojnosanit Pregl 63(6), 558
(2002): Tang OS+, Hum Reprod 17(7), 1738 (79%) (with
mifepristone)
Gynecomastia
(1994): Garcia-Rodriguez LA+, BMJ 308, 503
MISTLETOE
Scientific names: Phoradendron flavescens; Phoradendron
leucarpum; Phoradendron macrophyllum; Phoradendron rubrum;
Phoradendron serotinum; Phoradendron tomentosum; Viscum album
Family: Loranthacae; Viscaceae
Trade and other common names: ABNOBA viscum; All-heal;
Devil’s fuge; Eurixor; Folia Visci; Helixor; Herbe de la Croix;
Iscador (Weleda); Isorel (Novipharm); Lektinol; Lignum Crucis;
Stipites Visci; VaQuFrF (Labor Hiscia); Vysorel
Category: Immunomodulator
Purported indications and other uses: Injected: adjuvant
tumor therapy. Oral: abortifacient, arteriosclerosis, arthritis,
asthma, colds, depression, headache, HIV infection, hypertension,
hypotension, hysteria, labor pain, lumbago, metrorrhagia, muscle
spasms, otitis, whooping cough, hemorrhoids, internal bleeding,
gout, sleep disorders, amenorrhea, liver and gallbladder
conditions
Half-life: N/A
Clinically important, potentially hazardous interactions
with: bepridil, corticosteroids, digoxin, diltiazem,
immunosuppressants, MAO inhibitors, squill, verapamil
Note: Purified extracts injected intramuscularly, subcutaneously or
by intravenous infusion. Unless otherwise indicated, side effects listed
are from injected preparations. The FDA considers Viscum album
unsafe
Reactions
Skin
Adverse effects (sic)
(2005): Augustin M+, Arzneimittelforschung 55(1), 38 (12.8%)
(1999): Stein GM+, Eur J Med Res 4(5), 169
(1994): Stein G+, Eur J Clin Phamacol 47(1), 33
Allergic reactions (sic)
(2000): Büssing A, Mistletoe: The Genus Viscum Harwood
Academic Publishers
(1994): Stein G+, Eur J Clin Pharmacp; 47(1), 33
(1991): Pichler WJ+, Dtsch Med Wochenschr (German)
116(35), 1333
Dermatitis
(2000): Büssing A, Mistletoe: The Genus Viscum Harwood
Academic Publishers
Edema of lip
(1998): Hagenah W+, Dtsch Med Wochenschr (German)
123(34), 1001
Erythema
(2001): Hutt N+, Allergol Immunopathol (Madr) 29(5), 201
(1999): Stoss M+, Arzneimittelforschung 49(4), 366
(1999): van Wely+, Am J Ther 6(1), 37
Nodular eruption
(1998): Hagenah W+, Dtsch Med Wochenschr (German)
123(34), 1001
Pruritus
(1999): Stoss M+, Arzneimittelforschung 49(4), 366
Mucosal
Gingivitis
(1999): Gorter RW+, Altern Ther Health Med 5(6), 37
(1999): van Wely+, Am J Ther 6(1), 37
Other
Anaphylactoid reactions/Anaphylaxis (28%)
(2005): Bauer C+, Ann Allergy Asthma Immunol 94(1), 86 (1 case)
(2001): Hutt N+, Allergol Immunopathol (Madr) 29(5), 201
(1996): Friess H+, Anticancer Res 16(2), 915 (28%)
Chills
(2000): Büssing A, Mistletoe: The Genus Viscum Harwood
Academic Publishers
(1995): Murray MT, The Healing Power of Herbs 253 Prima
Publishing
Death (low incidence – accidental ingestion)
(1997): Krenzelok EP+, Am J Emerg 15(5), 516
(1996): Spiller HA+, J Toxicol Clin Toxicol 34(4), 405
(1995): Murray MT, The Healing Power of Herbs 253 Prima
Publishing
(1986): Hall AH+, Annals Emergency Med 15, 1320
Injection-site edema
(1999): Stoss M+, Arzneimittelforschung 49(4), 366
Injection-site inflammation
(1999): Stein GM+, Eur J Med Res 4(5), 169
(1999): Stoss M+, Arzneimittelforschung (German) 49(4), 366
(1998): Gorter RW+, Am J Ther 5(3), 181
(1998): Stoss M+, Nat Immun 16(5), 185
(1995): Murray MT, The Healing Power of Herbs 253 Prima
Publishing
(1990): Kast A+, Schweiz Rundsch Med Prax (German)
79(10), 291
Systemic reactions
(2005): Augustin M+, Arzneimittelforschung 55(1), 38 (3.3%)
*Note: The well-known mistletoe is an evergreen parasitic plant,
growing on the branches of some tree species
**Note: Shakespeare calls it ‘the baleful mistletoe,’ an illusion to the
Scandinavian legend that Balder, the god of Peace, was slain with an
arrow made of mistletoe
MITHRAMYCIN
(See PLICAMYCIN)
MITHRAMYCIN 373