Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

372 MINOXIDIL
Hair
Hair – alopecia [T]
(1987): Olsen EA, JAmAcadDermatol16, 145
(1983): Ingles RM+, Int J Dermatol 22, 120
Hair – hirsutism (in women) (100%)
(1981): Campese VM, Drugs 22, 257 (100%)
Hair – hypertrichosis (80–100%)
(2002): Litt JZ, Beachwood, OH (personal case) (observation)
(1997): Peluso AM+, Br J Dermatol 136, 118
(1995): Veyrac G+, Therapie (French) 50, 474 (in an infant)
(1994): Gonzalez M+, Clin Exp Dermatol 19, 157 [T]
(1990): Miwa LJ+, Drug Intell Clin Pharm 24, 365
(1989): Rousseau C+, Dermatologica 179, 221
(1988): Toriumi DN+, Arch Otolaryngol Head Neck Surg 114, 918
(1985): Bencini PL+, G Ital Dermatol Venereol (Italian) 120, 137
(1985): Lorette G+, Ann Dermatol Venereol (French) 112, 527
(1984): Henkes J+, Med Clin (Barc) (Spanish) 83, 89
(1983): Ingles RM+, Int J Dermatol 22, 120
(1983): Wilkin JK+, Cutis 31, 61
(1981): Campese VM, Drugs 22, 257 (100%)
(1981): Nielsen PG, Lakartidningen (Swedish) 78, 1891
(1980): Feldman HA+, Curr Ther Res 27, 205
(1980): Ryckmanns F, Hautarzt (German) 31, 205
Hair – pigmentation
(1989): Rebora A+, JAmAcadDermatol21, 1314
(1983): Ingles RM+, Int J Dermatol 22, 120 (red)
Other
Anaphylactoid reactions/Anaphylaxis
(2001): Blumenthal HL, Beachwood, OH (personal case)
(observation)
Gynecomastia
Tendinopathy/Tendon rupture [T]
MIRTAZAPINE
Trade name: Remeron (Organon)
Indications: Depression
Category: Adrenergic alpha-receptor agonist; Antidepressant,
tetracyclic
Half-life: 20–40 hours
Reactions
Skin
Acne
Allergic reactions (sic)
(2003): Biswas PN+, J Psychopharmacol 17(1), 121 (3 cases)
Cellulitis
Diaphoresis
(2001): Demers JC+, Ann Pharmacother 35(10), 1217
(1999): Leinonen E+, Int Clin Psychopharmacol 14, 329
Edema (1–10%)
(2003): Biswas PN+, J Psychopharmacol 17(1), 121 (5 cases)
Exfoliative dermatitis
Facial edema
Herpes simplex
Peripheral edema (1–10%)
(2001): Kutscher EC+, Ann Pharmacother 35(11), 1494
Petechiae
Photosensitivity
Pruritus
Rash (sic) (1–10%)
(2003): Biswas PN+, J Psychopharmacol 17(1), 121 (20 cases)
Seborrhea
Ulcerations
Xerosis
Mucosal
Aphthous stomatitis
Glossitis (1–10%)
Oral candidiasis
Sialorrhea
Stomatitis
Tongue edema
Tongue pigmentation
Vaginitis
Xerostomia (25%)
(2001): Anttila SA+, CNS Drug Rev 7(3), 249
(1995): Montgomery SA, Int Clin Psychopharmacol 10, 37
Other
Chills
Gynecomastia
(2006): Navarro-Gonzalez M+, Med Clin (Barc) 127(1), 37
(2005): Schmutz JL+, Ann Dermatol Venereol 132(2), 195
Hepatotoxicity
(2002): Hui CK+, J Clin Gastroenterol 35(3), 270
Inappropriate secretion of antidiuretic hormone (SIADH)
(2006): Bavbek N+, Am J Kidney Dis 48(4), e61
Myalgia/Myositis/Myopathy/Myotoxicity (1–10%)
(2001): Jolliet P+, Eur Psychiatry 16(8), 503
Phlebitis
Rhabdomyolysis
(2006): Zink M+, J Clin Psychiatry 67(5), 835 (with risperidone)
(2005): Kuliwaba A, Aust N Z J Psychiatry 39(4), 312
(2004): Khandat AB+, Ann Pharmacother 38(7-8), 1321
(1998): Retz W+, Int Clin Psychopharmacol 13(6), 277
Tendinopathy/Tendon rupture
Thrombosis
(2006): Zink M+, J Clin Psychiatry 67(5), 835 (with risperidone)
MISOPROSTOL
Trade names: Arthrotec (Kaken); Cytotec (Pfizer); Symbol
Indications: Prevention of NSAID-induced ulcer
Category: Corticosteroid antagonist; Progestogen antagonist
Half-life: 20–40 minutes
Arthrotec is diclofenac and misoprostol
Reactions
Skin
Dermatitis
Diaphoresis
Exanthems
(1987): Monk JP+, Drugs 33, 1
Rash (sic)
Shivering (17%)
(2002): Lumbiganon P+, BJOG 109(11), 1222
(2001): Elsheikh A+, Arch Gynecol Obstet 265(4), 204 (17.3%)
(2001): Gulmezoglu AM+, Lancet 358, 689
(2001): Li YT+, Zhonghua Yi Xue Za Zhi (Taipei) 64(12), 721
(33%)
(1999): Lumbiganon P+, Br J Obstet Gynaecol 106, 304
Mucosal
Gingivitis
Hair
Hair – alopecia