Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Reactions
Skin
Erythema multiforme
Pruritus (13%)
(2004): Young TM+, Ann Pharmacother 38(11), 1868
(1998): McClellan KJ+, Drugs Aging 12(1), 76
(1993): Jankovic J+, Am J Med 95(1), 38 (scalp) (13.5%)
Rash (sic) (2.4%)
Xerosis (2%)
Mucosal
Aphthous stomatitis
Xerostomia (1–10%)
Hair
Hair – pili torti
(1998): McClellan KJ+, Drugs Aging 12(1), 76
(1989): McTavish D+, Drugs 38(5), 757
Other
Chills (5%)
Pain (5%)
MIFEPRISTONE
Synonym: RU-486
Trade name: Mifeprex (Danco)
Indications: Medical termination of intrauterine pregnancy
Category: Corticosteroid antagonist; Progestogen antagonist
Half-life: ~20 hours
Reactions
Mucosal
Vaginitis (3%)
Other
Abdominal pain (89%)
(2003): Piaggio G+, Contraception 68(6), 439
(2002): Tang OS+, Hum Reprod 17(7), 1738 (89%) (with
misoprostol)
Chills (3–38%)
(2002): Tang OS+, Hum Reprod 17(7), 1738 (38%) (with
misoprostol)
Fever (79%)
(2002): Tang OS+, Hum Reprod 17(7), 1738 (79%) (with
misoprostol)
Infections
(2001): DeHart RM+, Ann Pharmacother 35(6), 707
MIGLITOL
Trade name: Glyset (Pfizer)
Indications: Non-insulin dependent diabetes type ll
Category: Alpha-glucosidase inhibitor
Half-life: ~2 hours
Skin
Rash (sic) (1–10%)
Reactions
Other
Abdominal pain
(2002): Drent ML+, Diabetes Nutr Metab 15(3), 152
(2000): Campbell LK+, Ann Pharmacother 34(11), 1291
(2000): Scott LJ+, Drugs 59(3), 521
MIGLUSTAT
Trade name: Zavesca (Actelion)
Indications: Gaucher’s disease
Category: Glucosylceramide synthase inhibitor
Half-life: 6–7 hours
Reactions
Skin
Burning (hands & feet)
Mucosal
Xerostomia (8%)
Other
Abdominal pain (50%)
Neurotoxicity
(2005): Prescrire Int 14(79), 168 (19%)
MILK THISTLE*
Scientific names: Carduus marainum; Silibum marianum
Family: Asteraceae; Compositae
Trade and other common names: Holy Thistle; Lady’s
Thistle; Marian Thistle; Mary Thistle; Silymarin
Category: Immunomodulator
Purported indications and other uses: Dyspepsia, liver
protectant, hepatitis, loss of appetite, spleen diseases, supportive
treatment for mushroom poisoning
Half-life: N/A
Reactions
Skin
Adverse effects (sic)
(2000): Evid Rep Technol p(21), 1
(1999): No Author, Med J Aust 170(5), 218
Allergic reactions (sic)
Diaphoresis
Rash (sic)
(2001): Saller R+, Drugs 61(14), 2035
Urticaria
(1990): Mironets VI+, Vrach Delo 7, 86
*Note: Seed as opposed to the ‘aboveground parts’
MILK THISTLE 367