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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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366 MEZLOCILLIN<br />

Nephrotoxicity<br />

(1986): Palla R+, Clin Nephrol 25(6), 315<br />

(1985): Cushner HM+, Arch Intern Med 145(7), 1204<br />

Phlebitis<br />

Serum sickness (5%)<br />

Injection-site pain (10%)<br />

(1980): Heel RC+, <strong>Drug</strong>s 19, 7 (0.5–2%)<br />

Phlebitis (5–79%)<br />

(1983): Stevens DA, <strong>Drug</strong>s 26, 347 (35%)<br />

(1980): Heel RC+, <strong>Drug</strong>s 19, 7 (6–28%)<br />

MIDAZOLAM<br />

Trade names: Dormicum; Versed (Roche)<br />

Indications: Preoperative sedation<br />

Category: Benzodiazepine<br />

Half-life: 1–4 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amprenavir, aprepitant, atazanavir, carbamazepine,<br />

chlorpheniramine, cimetidine, clarithromycin, clorazepate, CNS<br />

depressants, darunavir, delavirdine, dexamethasone, efavirenz,<br />

erythromycin, esomeprazole, fluconazole, fluoxetine,<br />

fosamprenavir, grapefruit juice, griseofulvin, imatinib, indinavir,<br />

itraconazole, ivermectin, ketoconazole, nelfinavir, nevirapine,<br />

phenobarbital, phenytoin, primidone, rifabutin, rifampin,<br />

ritonavir, roxithromycin, saquinavir, St John’s wort,<br />

telithromycin, tipranavir<br />

Reactions<br />

Skin<br />

Adverse effects<br />

(1993): Kundrotas L+, Gastrointest Endosc 39, 109<br />

Angioedema<br />

(1992): Yakel DL+, Crit Care Med 20, 307<br />

Edema<br />

(2006): Uchimura A+, Masui 55(1), 76<br />

Exanthems<br />

Facial edema<br />

(2006): Uchimura A+, Masui 55(1), 76<br />

Peripheral edema (

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