Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

METOCLOPRAMIDE
Trade names: Apo-Metoclop; Duraclamid; Emex; Gastrocil;
Gastronerton; Maxeran; Maxolon; Mygdalon; Primperan; Reglan
(Wyeth)
Indications: Gastroesophageal reflux
Category: Dopamine receptor antagonist
Half-life: 4–6 hours
Clinically important, potentially hazardous interactions
with: mepenzolate, sertraline, venlafaxine
Reactions
Skin
Allergic reactions (sic)
(1986): Bigby M+, JAMA 256, 3358
Angioedema
(1983): Pinder RM+, Drugs 25, 451
Diaphoresis
(2002): Fisher AA+, Ann Pharmacother 36(1), 67
Exanthems
(1983): Pinder RM+, Drugs 25, 451
Rash (sic) (1–10%)
Urticaria
(1983): Pinder RM+, Drugs 25, 451
Mucosal
Tongue pigmentation
(1989): Alroe C+, Med J Aust 150, 724
Xerostomia (1–10%)
Eyes
Oculogyric crisis
(2006): Hibbs AM+, Pediatrics 118(2), 746
Other
Abdominal pain
(2006): Khan NU+, J Emerg Med 30(4), 411
Anaphylactoid reactions/Anaphylaxis
(2006): Kerstan A+, Ann Pharmacother 40(10), 1889
Gynecomastia
(1997): Madani S+, J Clin Gastroenterol 24, 79
Porphyria
(1997): Gorchein A, Lancet 350, 1104
(1981): Doss M+, Lancet 2, 91
METOLAZONE*
Trade names: Barolyn; Diondel; Metenix 5; Normelan; Xuret;
Zaroxolyn (Celltech)
Indications: Hypertension, edema
Category: Diuretic, thiazide
Half-life: 6–20 hours
Clinically important, potentially hazardous interactions
with: digoxin, lithium
Reactions
Skin
Edema (