Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(1998): Corazza M+, Contact Dermatitis 38(6), 356 (1997): Balato N+, Am J Contact Dermat 8(1), 24 (1992): Aramoto Y+, JDermatol19(6), 375 Erythroderma (1991): Fernandez de+, Contact Dermatitis 25(1), 68 Kaposi’s sarcoma (2004): Monti M+, J Eur Acad Dermatol Venereol 18(2), 191 Perioral dermatitis (2001): Chow ET, Australas J Dermatol 42(1), 62 Pruritus (2005): Hardy D, Can J Anaesth 52(2), 186 (with bupivacaine & epinephrine) (2002): Mignogna MD+, JOralPatholMed31(6), 339 Rash (sic) (2004): Kuga A+, Rinsho Shinkeigaku 44(10), 691 (2001): Macchia PE+, J Endocrinol Invest 24(3), 152 Stevens–Johnson syndrome (2002): Samimi SS+, Pediatr Dermatol 19(1), 52 Thinning Urticaria (2001): Borja JM+, Allergy 56(8), 791 (2001): Pollack B+, Br J Dermatol 144, 1228 (1996): Pizzuti P+, Rev Rhum Engl Ed 63(3), 223 (1990): Sieck JO+, Br J Clin Pract 44(12), 723 Hair Hair – hypertrichosis Eyes Cataract (2003): Nakamura T+, Jpn J Ophthalmol 47(3), 254 (with cyclosporine) (1999): Marsh P+, Ophthalmology 106(4), 811 (1992): Yokota S+, Ryumachi 32(3), 215 Conjunctival ulceration (1999): Zamir E+, Ophthalmic Surg Lasers 30(7), 565 Glaucoma (1995): Katsushima H, Nippon Ganka Gakkai Zasshi 99(2), 238 (1992): Yokota S+, Ryumachi 32(3), 215 Ocular pain Ocular pressure (1999): Marsh P+, Ophthalmology 106(4), 811 Ophthalmitis (2003): Mazur-Chlodek L+, Klin Oczna 105(3-4), 194 Periorbital urticaria (1992): John GR+, Am J Ophthalmol 113(5), 588 Visual disturbances (1991): Bettinelli A+, Child Nephrol Urol 11(1), 41 Other Abdominal pain (1994): Chassard D+, Presse Med 23(11), 515 Adverse effects (2005): Chibane S+, Rev Med Interne 26(1), 20 (1992): Pozzi C+, Nephron 60(2), 235 Anaphylactoid reactions/Anaphylaxis (2004): Saito R+, Int J Urol 11(3), 171 (2002): Burgdorff T+, Ann Allergy Asthma Immunol 89(4), 425 (2000): Young MF+, J Neurol Neurosurg Psychiatry 68(2), 255 (1999): Beynel P+, Rev Mal Respir 16(4), 529 (1999): Schonwald S, Am J Emerg Med 17(6), 583 (1997): Mace S+, J Rheumatol 24(6), 1191 (1997): van den Berg JS+, J Neurol Neurosurg Psychiatry 63(6), 813 (1996): Moreno-Ancillo A+, J Allergy Clin Immunol 97(5), 1169 (1993): Hopper JM+, J Bone Joint Br 75(3), 505 (with bupivacaine) (1993): Watanabe I+, Masui 42(1), 112 (1991): Peces R+, Nephron 59(3), 497 METHYLTESTOSTERONE 361 (1990): Laine-Cessac P+, Therapie 45(6), 505 Hepatotoxicity (2006): Topal F+, Ann Pharmacother 40(10), 1868 Hypersensitivity (2006): Sirvent AE+, Nefrologia 26(1), 128 (2006): Venturini M+, J Investig Allergol Clin Immunol 16(1), 51 (1996): Lopez-Serrano MC+, J Investig Allergol Clin Immunol 6(5), 324 Infections (2004): Kulig G+, Przegl Lek 61(8), 855 (2004): Offidani M+, Leuk Lymphoma 45(8), 1617 (2004): Tanaka Y, Nippon Rinsho 62(10), 1867 (1994): Sayer HG+, Blood 84(4), 1328 (1992): Baethge BA+, Ann Pharmacother 26(3), 316 Injection-site lipoatrophy (2000): Anderson B+, Arch Intern Med 151, 153 Lymphoproliferative disease (2002): Theate I+, Eur J Haematol 69(4), 248 (with methotrexate) Myalgia/Myositis/Myopathy/Myotoxicity (2006): Lee HJ+, Bone Marrow Transplant 38(4), 299 (2005): Qian T+, Spinal Cord 43(4), 199 (2001): Odabas AR+, Nephron 87(1), 95 (2000): Qian T+, Med Hypotheses 55(5), 452 Neurotoxicity (2004): Fodale V+, Br J Anaesth 92(2), 289 (with cisatracurium) Tendinopathy/Tendon rupture (2005): Chiou YM+, Lupus 14(4), 321 METHYLTESTOSTERONE Trade names: Android (Valeant); Androral; B; Enarmon; Estratest (Solvay); Metandren; Teston; Testotonic ‘B’; Testovis; Testred (Valeant); Virilon; Viromone Indications: Hypogonadism, impotence, metastatic breast cancer Category: Androgen Half-life: 2.5–3.5 hours Clinically important, potentially hazardous interactions with: anticoagulants, cyclosporine, warfarin Reactions Skin Acanthosis nigricans (1987): Shuttleworth D+, Clin Exp Dermatol 12, 288 Acne (>10%) (1992): Fryand O+, Acta Derm Venereol 72, 148 (1990): Fuchs E+, JAmAcadDermatol23, 125 (1989): Fryand O+, Tidsskr Nor Laegeforen (Norwegian) 109, 239 (1989): Hartmann AA+, Monatsschr Kinderheilkd (German) 137, 466 (1989): Heydenreich G, Arch Dermatol 125, 571 (fulminans) (1989): Scott MJ+, Cutis 44, 30 (1989): von Muhlendahl KE+, Dtsch Med Wochenschr (German) 114, 712 (1988): Traupe H+, Arch Dermatol 124, 414 (fulminans) (1987): Kiraly CL+, Am J Dermatopathol 9, 515 (1984): Lamb DR, Am J Sports Med 12, 31 Dermatitis (1989): Holdiness MR, Contact Dermatitis 20, 3 (from patch) Edema (>10%) Exanthems Furunculosis (1989): Scott MJ+, Cutis 44, 30

362 METHYLTESTOSTERONE Lichenoid eruption (1989): Aihara M+, JDermatol(Tokio) 16, 330 Lupus erythematosus Pruritus Psoriasis (1990): O’Driscoll JB+, Clin Exp Dermatol 15, 68 Purpura Seborrhea Seborrheic dermatitis (1989): Scott MJ+, Cutis 44, 30 Striae (1989): Scott MJ+, Cutis 44, 30 Urticaria Mucosal Stomatitis Hair Hair – alopecia (1989): Scott MJ+, Cutis 44, 30 Hair – hirsutism (1–10%) (in females) (1994): Castillo-Ceballos A+, Med Clin (Barc) (Spanish) 102, 78 (1991): Bates GW+, Clin Obstet Gynecol 34, 848 (1991): No Author, Obstet Gynecol 78, 474 (1991): Parker LU+, Cleve Clin J Med 58, 43 (1991): Urman B+, Obstet Gynecol 77, 595 (1989): Scott MJ+, Cutis 44, 30 Eyes Intraocular pressure increased (2006): Khurana RN+, Am J Ophthalmol 142(3), 494 Other Anaphylactoid reactions/Anaphylaxis Gynecomastia (

362 METHYLTESTOSTERONE<br />

Lichenoid eruption<br />

(1989): Aihara M+, JDermatol(Tokio) 16, 330<br />

Lupus erythematosus<br />

Pruritus<br />

Psoriasis<br />

(1990): O’Driscoll JB+, Clin Exp Dermatol 15, 68<br />

Purpura<br />

Seborrhea<br />

Seborrheic dermatitis<br />

(1989): Scott MJ+, Cutis 44, 30<br />

Striae<br />

(1989): Scott MJ+, Cutis 44, 30<br />

Urticaria<br />

Mucosal<br />

Stomatitis<br />

Hair<br />

Hair – alopecia<br />

(1989): Scott MJ+, Cutis 44, 30<br />

Hair – hirsutism (1–10%) (in females)<br />

(1994): Castillo-Ceballos A+, Med Clin (Barc) (Spanish) 102, 78<br />

(1991): Bates GW+, Clin Obstet Gynecol 34, 848<br />

(1991): No Author, Obstet Gynecol 78, 474<br />

(1991): Parker LU+, Cleve Clin J Med 58, 43<br />

(1991): Urman B+, Obstet Gynecol 77, 595<br />

(1989): Scott MJ+, Cutis 44, 30<br />

Eyes<br />

Intraocular pressure increased<br />

(2006): Khurana RN+, Am J Ophthalmol 142(3), 494<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

Gynecomastia (

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