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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(1998): Corazza M+, Contact Dermatitis 38(6), 356<br />

(1997): Balato N+, Am J Contact Dermat 8(1), 24<br />

(1992): Aramoto Y+, JDermatol19(6), 375<br />

Erythroderma<br />

(1991): Fern<strong>and</strong>ez de+, Contact Dermatitis 25(1), 68<br />

Kaposi’s sarcoma<br />

(2004): Monti M+, J Eur Acad Dermatol Venereol 18(2), 191<br />

Perioral dermatitis<br />

(2001): Chow ET, Australas J Dermatol 42(1), 62<br />

Pruritus<br />

(2005): Hardy D, Can J Anaesth 52(2), 186 (with bupivacaine &<br />

epinephrine)<br />

(2002): Mignogna MD+, JOralPatholMed31(6), 339<br />

Rash (sic)<br />

(2004): Kuga A+, Rinsho Shinkeigaku 44(10), 691<br />

(2001): Macchia PE+, J Endocrinol Invest 24(3), 152<br />

Stevens–Johnson syndrome<br />

(2002): Samimi SS+, Pediatr Dermatol 19(1), 52<br />

Thinning<br />

Urticaria<br />

(2001): Borja JM+, Allergy 56(8), 791<br />

(2001): Pollack B+, Br J Dermatol 144, 1228<br />

(1996): Pizzuti P+, Rev Rhum Engl Ed 63(3), 223<br />

(1990): Sieck JO+, Br J Clin Pract 44(12), 723<br />

Hair<br />

Hair – hypertrichosis<br />

Eyes<br />

Cataract<br />

(2003): Nakamura T+, Jpn J Ophthalmol 47(3), 254 (with<br />

cyclosporine)<br />

(1999): Marsh P+, Ophthalmology 106(4), 811<br />

(1992): Yokota S+, Ryumachi 32(3), 215<br />

Conjunctival ulceration<br />

(1999): Zamir E+, Ophthalmic Surg Lasers 30(7), 565<br />

Glaucoma<br />

(1995): Katsushima H, Nippon Ganka Gakkai Zasshi 99(2), 238<br />

(1992): Yokota S+, Ryumachi 32(3), 215<br />

Ocular pain<br />

Ocular pressure<br />

(1999): Marsh P+, Ophthalmology 106(4), 811<br />

Ophthalmitis<br />

(2003): Mazur-Chlodek L+, Klin Oczna 105(3-4), 194<br />

Periorbital urticaria<br />

(1992): John GR+, Am J Ophthalmol 113(5), 588<br />

Visual disturbances<br />

(1991): Bettinelli A+, Child Nephrol Urol 11(1), 41<br />

Other<br />

Abdominal pain<br />

(1994): Chassard D+, Presse Med 23(11), 515<br />

Adverse effects<br />

(2005): Chibane S+, Rev Med Interne 26(1), 20<br />

(1992): Pozzi C+, Nephron 60(2), 235<br />

Anaphylactoid reactions/Anaphylaxis<br />

(2004): Saito R+, Int J Urol 11(3), 171<br />

(2002): Burgdorff T+, Ann Allergy Asthma Immunol 89(4), 425<br />

(2000): Young MF+, J Neurol Neurosurg Psychiatry 68(2), 255<br />

(1999): Beynel P+, Rev Mal Respir 16(4), 529<br />

(1999): Schonwald S, Am J Emerg Med 17(6), 583<br />

(1997): Mace S+, J Rheumatol 24(6), 1191<br />

(1997): van den Berg JS+, J Neurol Neurosurg Psychiatry<br />

63(6), 813<br />

(1996): Moreno-Ancillo A+, J Allergy Clin Immunol 97(5), 1169<br />

(1993): Hopper JM+, J Bone Joint Br 75(3), 505 (with<br />

bupivacaine)<br />

(1993): Watanabe I+, Masui 42(1), 112<br />

(1991): Peces R+, Nephron 59(3), 497<br />

METHYLTESTOSTERONE 361<br />

(1990): Laine-Cessac P+, Therapie 45(6), 505<br />

Hepatotoxicity<br />

(2006): Topal F+, Ann Pharmacother 40(10), 1868<br />

Hypersensitivity<br />

(2006): Sirvent AE+, Nefrologia 26(1), 128<br />

(2006): Venturini M+, J Investig Allergol Clin Immunol 16(1), 51<br />

(1996): Lopez-Serrano MC+, J Investig Allergol Clin Immunol<br />

6(5), 324<br />

Infections<br />

(2004): Kulig G+, Przegl Lek 61(8), 855<br />

(2004): Offidani M+, Leuk Lymphoma 45(8), 1617<br />

(2004): Tanaka Y, Nippon Rinsho 62(10), 1867<br />

(1994): Sayer HG+, Blood 84(4), 1328<br />

(1992): Baethge BA+, Ann Pharmacother 26(3), 316<br />

Injection-site lipoatrophy<br />

(2000): Anderson B+, Arch Intern Med 151, 153<br />

Lymphoproliferative disease<br />

(2002): Theate I+, Eur J Haematol 69(4), 248 (with<br />

methotrexate)<br />

Myalgia/Myositis/Myopathy/Myotoxicity<br />

(2006): Lee HJ+, Bone Marrow Transplant 38(4), 299<br />

(2005): Qian T+, Spinal Cord 43(4), 199<br />

(2001): Odabas AR+, Nephron 87(1), 95<br />

(2000): Qian T+, Med Hypotheses 55(5), 452<br />

Neurotoxicity<br />

(2004): Fodale V+, Br J Anaesth 92(2), 289 (with cisatracurium)<br />

Tendinopathy/Tendon rupture<br />

(2005): Chiou YM+, Lupus 14(4), 321<br />

METHYLTESTOSTERONE<br />

Trade names: Android (Valeant); Androral; B; Enarmon;<br />

Estratest (Solvay); Met<strong>and</strong>ren; Teston; Testotonic ‘B’; Testovis;<br />

Testred (Valeant); Virilon; Viromone<br />

Indications: Hypogonadism, impotence, metastatic breast<br />

cancer<br />

Category: Androgen<br />

Half-life: 2.5–3.5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticoagulants, cyclosporine, warfarin<br />

Reactions<br />

Skin<br />

Acanthosis nigricans<br />

(1987): Shuttleworth D+, Clin Exp Dermatol 12, 288<br />

Acne (>10%)<br />

(1992): Fry<strong>and</strong> O+, Acta Derm Venereol 72, 148<br />

(1990): Fuchs E+, JAmAcadDermatol23, 125<br />

(1989): Fry<strong>and</strong> O+, Tidsskr Nor Laegeforen (Norwegian)<br />

109, 239<br />

(1989): Hartmann AA+, Monatsschr Kinderheilkd (German)<br />

137, 466<br />

(1989): Heydenreich G, Arch Dermatol 125, 571 (fulminans)<br />

(1989): Scott MJ+, Cutis 44, 30<br />

(1989): von Muhlendahl KE+, Dtsch Med Wochenschr (German)<br />

114, 712<br />

(1988): Traupe H+, Arch Dermatol 124, 414 (fulminans)<br />

(1987): Kiraly CL+, Am J Dermatopathol 9, 515<br />

(1984): Lamb DR, Am J Sports Med 12, 31<br />

Dermatitis<br />

(1989): Holdiness MR, Contact Dermatitis 20, 3 (from patch)<br />

Edema (>10%)<br />

Exanthems<br />

Furunculosis<br />

(1989): Scott MJ+, Cutis 44, 30

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