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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(1987): Norris PG+, Clin Exp Dermatol 12, 403<br />

(1983): Tegner E, Acta Derm Venereol (Stockh) Suppl 107, 5<br />

Tumors<br />

(1988): Gupta AK+, JAmAcadDermatol19, 67<br />

(1987): Henseler T+, JAmAcadDermatol16, 108<br />

METHOXYFLURANE<br />

Trade name: Penthrane (Abbott) (Ger)<br />

Indications: Anesthesia<br />

Category: Anesthetic, inhalation<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: cisatracurium, demeclocycline, doxacurium, doxycycline,<br />

gentamicin, kanamycin, minocycline, neomycin, oxytetracycline,<br />

pancuronium, rapacuronium, streptomycin, tetracycline<br />

Reactions<br />

Other<br />

Hepatotoxicity<br />

(1983): Delia JE+, Int J Gynaecol Obstet 21(1), 89<br />

(1982): Zeana CD+, Med Interne 20(4), 295<br />

Nephrotoxicity<br />

(1996): Bosch T, Anaesthesist 45 Suppl 1, S41<br />

(1995): Kharasch ED+, Anesthesiology 82(3), 689<br />

(1987): Toomath RJ+, NZMedJ100(836), 707<br />

(1982): Mazzia VD, Leg Med 59<br />

METHSUXIMIDE<br />

Trade names: Celontin (Pfizer); Petinutin<br />

Indications: Absence (petit-mal) seizures<br />

Category: Antiepileptic, succinimide<br />

Half-life: 2–4 hours<br />

Reactions<br />

Skin<br />

Acanthosis nigricans<br />

Erythema multiforme<br />

Exanthems<br />

Exfoliative dermatitis (10%)<br />

Pruritus<br />

Purpura<br />

Rash (sic)<br />

Stevens–Johnson syndrome (>10%)<br />

Urticaria (

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