Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

358 METHOXSALEN
METHOXSALEN
Trade names: 8-MOP (Valeant); Geroxalen; Meladinine;
Oxsoralen (Valeant); Oxsoralon; Puvasoralen; Ultra-MOP
Indications: Psoriasis, vitiligo
Category: Psoralen; Repigmenting agent
Half-life: 1.1 hours
Clinically important, potentially hazardous interactions
with: caffeine, chloroquine, cyclosporine, fluoroquinolones,
phenothiazines, sulfonamides
Reactions
Skin
Acne
Acute generalized exanthematous pustulosis (AGEP)
(2002): Morant C+, Ann Dermatol Venereol 129(2), 234
Basal cell carcinoma
(1996): Stern RS+, JPediatr129, 915
(1995): Gritiyarangsan P+, Photodermatol Photoimmunol
Photomed 11, 174
Bowen’s disease
Bullous dermatitis (with UVA)
(1982): Stüttgen G, Int J Dermatol 21, 198
Bullous pemphigoid
(1996): Perl S+, Dermatology 193, 245
Burning (1–10%)
(1996): Geary P, Burns 22, 636
(1991): Boucaud C+, Presse Med (French) 20, 1945
(1982): Stüttgen G, Int J Dermatol 21, 198 (passim) (1–10%)
Carcinoma
(1995): Halder RM+, Arch Dermatol 131, 734
(1984): Halprin KM+, Natl Cancer Inst Monogr 66, 185
Dermatitis
(1994): Korffmacher H+, Contact Dermatitis 30, 283
(1991): Takashima A+, Br J Dermatol 124, 37
(1980): Weissmann I+, Br J Dermatol 102, 113
Eczema
Edema (1–10%)
Ephelides (1–10%)
(1995): Gritiyarangsan P+, Photodermatol Photoimmunol
Photomed 11, 174
(1995): Pierard GE+, Dermatology 190, 338
(1984): Kietzmann E+, Dermatologica 168, 306
(1983): Kanerva L+, Dermatologica 166, 281
(1983): Kietzmann H+, Ann Dermatol Venereol (French) 110, 63
Erythema (1–10%)
Exanthems
(2001): Ravenscroft J+, JAmAcadDermatol45, S2118–9
(1986): Gisslen P+, Photodermatol 3, 308
Exfoliative dermatitis
Granuloma annulare
Herpes simplex
(1982): Stüttgen G, Int J Dermatol 21, 198
Herpes zoster
(1982): Stüttgen G, Int J Dermatol 21, 198
Hypomelanosis (1–10%)
Lichen planus
(2003): Nanda S+, JDermatol30(2), 151
Lichen planus pemphigoides
(2000): Kuramoto N+, Br J Dermatol 142(3), 509
Lupus erythematosus
(1985): Bruze M+, Acta Derm Venereol (Stockh) 65, 31
Miliaria
Pemphigus
Photosensitivity
(2001): Tanew A+, JAmAcadDermatol44, 638
(1998): Clark SM+, Contact Dermatitis 38, 289
(1992): Jeanmougin M+, Ann Dermatol Venereol (French)
119, 277
(1991): Boucaud C+, Presse Med (French) 20, 1945
(1991): Takashima A+, Br J Dermatol 124, 37
(1990): Cox NH+, Clin Exp Dermatol 15, 75
(1989): Cox NH+, Photodermatol 6, 96
Phototoxicity
(1997): Morison WL+, JAmAcadDermatol36, 183
(1993): Calzavara-Pinton PG+, JAmAcadDermatol28, 657
(1989): Morison WL, Arch Dermatol 125, 433 (topical)
(1985): Berakha GJ+, Ann Plast Surg 14, 458
(1984): Meffert H+, Photodermatol 1, 191
Pigmentation
(1989): Weiss E+, Int J Dermatol 28, 188
(1987): Bruce DR+, JAmAcadDermatol16, 1087
(1986): MacDonald KJS+, Br J Dermatol 114, 395
Porokeratosis (actinic)
(1988): Beiteke U+, Photodermatol 5, 274
(1985): Hazen PG+, JAmAcadDermatol12, 1077
(1980): Reymond JL, Acta Derm Venereol (Stockh) 60, 539
Prurigo
(1982): Stüttgen G, Int J Dermatol 21, 198 (passim)
Pruritus (>10%)
(1982): Stüttgen G, Int J Dermatol 21, 198 (passim)
Purpura
(1981): Barriere H+, Nouv Presse Med (French) 10, 337
Rash (sic) (1–10%)
Scleroderma
Seborrheic dermatitis
(1983): Tegner E, Acta Derm Venereol (Stockh) Suppl 107, 5
Squamous cell carcinoma
(1998): Stern RS+, Arch Dermatol 134, 1582 (with UVA)
(1986): Kahn JR+, Clin Exp Dermatol 11, 398
Urticaria
(1994): Bech-Thomsen N+, JAmAcadDermatol31, 1063
Vasculitis
(1981): Barriere H+, Presse Med (French) 10, 37
Verrucae
(1982): Stüttgen G, Int J Dermatol 21, 198
Vitiligo
(1983): Tegner E, Acta Derm Venereol (Stockh) Suppl 107, 5
Xerosis
Mucosal
Cheilitis (1–10%)
Hair
Hair – hypertrichosis
(1983): Rampen FHJ, Br J Dermatol 109, 657
Nails
Nails – photo-onycholysis
(1990): Baran R+, Ann Dermatol Venereol (French) 117, 367
(1984): Balato N+, Photodermatol 1, 202
Nails – pigmentation
(1990): Trattner A+, Int J Dermatol 29, 310
(1989): Weiss E+, Int J Dermatol 28, 188
(1986): MacDonald KJS+, Br J Dermatol 114, 395
(1982): Naik RPC+, Int J Dermatol 21, 275
Other
Anaphylactoid reactions/Anaphylaxis
(2003): Park JY+, Photodermatol Photoimmunol Photomed
19(1), 37
(2001): Legat FJ+, Br J Dermatol 145(5), 821
Lymphoproliferative disease
(1989): Aschinoff R+, JAmAcadDermatol21, 1134
Pain