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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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MERCAPTOPURINE<br />

Synonyms: 6-mercaptopurine; 6-MP<br />

Trade names: Classen; Ismipur; Leukerin; Puri-Nethol;<br />

Purinethol (Gate)<br />

Indications: Leukemias<br />

Category: Antimetabolite; Antineoplastic<br />

Half-life: triphasic: 45 minutes; 2.5 hours; 10 hours<br />

Clinically important, potentially hazardous interactions<br />

with: aldesleukin, allopurinol, influenza vaccines,<br />

mycophenolate, olsalazine, vaccines<br />

Reactions<br />

Skin<br />

Acral erythema<br />

(1991): Baack BR+, JAmAcadDermatol24, 457<br />

Dermatitis (2%)<br />

Edema<br />

Exanthems (

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