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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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348 MEPHENYTOIN<br />

Edema<br />

Erythema multiforme<br />

Exanthems (8–10%)<br />

Exfoliative dermatitis<br />

Lupus erythematosus<br />

(1989): Vivino FB+, Arthritis Rheum 32, 560<br />

(1980): Condemi JJ, Geriatrics 35(3), 81<br />

Pigmentation<br />

Pruritus<br />

Purpura<br />

Scleroderma<br />

(1990): May DG+, Clin Pharmacol Ther 28, 286<br />

Side effects (sic)<br />

Stevens–Johnson syndrome<br />

Toxic epidermal necrolysis<br />

Urticaria<br />

Mucosal<br />

Gingival hyperplasia/hypertrophy<br />

Oral mucosal eruption<br />

Stomatitis<br />

(1996): Meloni G+, Lancet 347, 1691<br />

Hair<br />

Hair – alopecia<br />

Other<br />

Polyarteritis nodosa<br />

MEPHOBARBITAL<br />

Trade names: Mebaral; Prominal<br />

Indications: Epilepsy, anxiety<br />

Category: Barbiturate<br />

Half-life: 34 hours<br />

Clinically important, potentially hazardous interactions<br />

with: alcohol, anticoagulants, antihistamines, brompheniramine,<br />

buclizine, chlorpheniramine, dicumarol, ethanolamine, imatinib,<br />

warfarin<br />

Reactions<br />

Skin<br />

Angioedema (

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