Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW
Other Abdominal pain (7%) Cough (1%) Fever (1%) Myalgia/Myositis/Myopathy/Myotoxicity (1%) Pain (~0.2%) Upper respiratory infection (4%) LUMIRACOXIB Trade name: Prexige (Novartis) Indications: Osteoarthritis Category: COX-2 selective inhibitor NSAID Half-life: 4 hours Clinically important, potentially hazardous interactions with: aspirin. other NSAIDs Reactions Skin Angioedema Exfoliative dermatitis Peripheral edema (2%) Stevens–Johnson syndrome Toxic epidermal necrolysis Other Abdominal pain (1%) Anaphylactoid reactions/Anaphylaxis Cough (2%) Hepatotoxicity Myalgia/Myositis/Myopathy/Myotoxicity (1.5%) LUTROPIN ALFA Trade name: Luveris (Merck) Indications: Infertility Category: Hormone modulator; Luteinizing hormone Half-life: ~14 hours Skin Edema Erythema Pruritus Rash (sic) Urticaria Vesiculation Xerosis Hair Hair – alopecia Other Abdominal pain (5–8%) Chills Fever Gynecomastia Injection-site edema Injection-site irritation Injection-site pain Reactions Injection-site reactions (3–4%) Upper respiratory infection (1–2%) LYCOPENE Scientific names: All-Trans-Lycopene; Psi-Psi-Carotene Trade and other common names: Carotenoid; Lyc-O-Mato; Lycovit (BASF) Category: Antioxidant Purported indications and other uses: Cancer (prevention), cardiovascular disease (prevention), asthma Half-life: N/A Note: Cooking increases bioavailability of lycopene. Major dietary sources are tomato paste, juice, and ketchup Reactions Skin Pigmentation (2003): Saldana Chaparro RS+, Ann Clin Biochem 40(Pt 3), 280 MAFENIDE* Trade name: Sulfamylon Indications: Second- and third-degree burns Category: Antiseptic; Sulfonamide Half-life: N/A Clinically important, potentially hazardous interactions with: None *Note: Mafenide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens–Johnson syndrome Reactions MAFENIDE 339 Skin Allergic reactions (sic) (1995): McKenna SR+, Burns 21(4), 310 Bullous dermatitis Burning Dermatitis (1993): Sanz de Galdeano C+, Contact Dermatitis 28(4), 249 (1992): Fernandez JC+, Contact Dermatitis 27(4), 262 Edema Erythema Excoriations Facial edema Pruritus (2.8%) (1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158 Rash (sic) (4.6%) (1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158 Other Anaphylactoid reactions/Anaphylaxis Application-site burning Death Hypersensitivity (1988): Perry AW+, J Burn Care Rehabil 9(2), 145 Pain (1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158 Porphyria
340 MAPROTILINE MAPROTILINE Trade names: Delgian; Ludiomil (Novartis); Maprostad; Melodil; Mirpan; Nono-Maprotiline; Psymion; Retinyl Indications: Depression, anxiety Category: Antidepressant, tetracyclic; Muscarinic antagonist Half-life: 27–58 hours Reactions Skin Acne (1988): Warnock JK+, Am J Psychiatry 145, 425 (1985): Oakley AM+, Aust N Z J Med 15, 256 (1982): Ponte CD, Am J Psychiatry 139, 141 Diaphoresis (3–8%) Edema Erythema Erythema multiforme (1990): Zukervar P+, J Toxicol Clin Exp 10, 169 Exanthems (1–9%) (1988): Warnock JK+, Am J Psychiatry 145, 425 Ichthyosis (1991): Niederauer HH+, Hautarzt (German) 42, 455 Petechiae Photosensitivity (1989): KochP+, Derm Beruf Umwelt (German) 37, 203 (1988): Warnock JK+, Am J Psychiatry 145, 425 Pruritus Purpura (1988): Warnock JK+, Am J Psychiatry 145, 425 Rash (sic) (>10%) Stevens–Johnson syndrome (1990): Zukervar P+, J Toxicol Clin Exp 10, 169 Urticaria (4%) (1988): Warnock JK+, Am J Psychiatry 145, 425 Vasculitis (1985): Oakley AM+, Aust N Z J Med 15, 256 Mucosal Sialorrhea Stomatitis Tongue black Xerostomia (20–40%) (1981): Rafaelsen OJ+, Acta Psychiatr Scand Suppl 290, 364 Hair Hair – alopecia (2000): Mercke Y+, Ann Clin Psychiatry 12, 35 (1991): Niederauer HH+, Hautarzt (German) 42, 455 Other Gynecomastia (
- Page 364 and 365: (2001): Fife KH+, Sex Transm Dis 28
- Page 366 and 367: Herpes simplex (
- Page 368 and 369: (2004): Scheinfeld N, J Drugs Derma
- Page 370 and 371: (2000): Poole PJ+, Cochrane Databas
- Page 372 and 373: Injection-site pain (2006): Moyes V
- Page 374 and 375: (2002): Tothova E+, Neoplasma 49(2)
- Page 376 and 377: (1995): Shinohara K, NEnglJMed333,
- Page 378 and 379: IOPROMIDE Trade name: Ultravist (Be
- Page 380 and 381: ISOCARBOXAZID Trade names: Enerzer;
- Page 382 and 383: ISOSORBIDE Trade name: Ismotic Indi
- Page 384 and 385: Nails Nails - brittle (2001): Önde
- Page 386 and 387: Serum sickness (1998): Park H+, Ann
- Page 388 and 389: (2001): Burstal R+, Anaesth Intensi
- Page 390 and 391: Pruritus (1-10%) Psoriasis (1992):
- Page 392 and 393: LAMIVUDINE Synonym: 3TC Trade names
- Page 394 and 395: (2006): Fix OK+, Clin Gastroenterol
- Page 396 and 397: Eyelashes - ptosis (2005): Casson R
- Page 398 and 399: LETROZOLE Trade name: Femara (Novar
- Page 400 and 401: Other Abdominal pain (2003): Cramer
- Page 402 and 403: Photosensitivity (
- Page 404 and 405: (2002): Kalin JR+, JForensicSci47(5
- Page 406 and 407: (2002): Serratrice J+, Am J Ophthal
- Page 408 and 409: (1981): Hess EV, Arthritis Rheum 24
- Page 410 and 411: Purpura (
- Page 412 and 413: Reactions Skin Angioedema (
- Page 416 and 417: Reactions Skin Acne (1998): Wollina
- Page 418 and 419: (1983): Nusbaum BP+, Arch Dermatol
- Page 420 and 421: (1997): O’Reilly FM+, American Ac
- Page 422 and 423: MEMANTINE Trade names: Akatinol; Ax
- Page 424 and 425: MERCAPTOPURINE Synonyms: 6-mercapto
- Page 426 and 427: (1998): Leal G, Fortaleza, Brazil (
- Page 428 and 429: (2002): Caplehorn JR+, Aust N Z J P
- Page 430 and 431: (1995): Vogt T+, Br J Dermatol 133,
- Page 432 and 433: Mucosal Aphthous stomatitis (2003):
- Page 434 and 435: (1987): Norris PG+, Clin Exp Dermat
- Page 436 and 437: (1998): Corazza M+, Contact Dermati
- Page 438 and 439: METOCLOPRAMIDE Trade names: Apo-Met
- Page 440 and 441: Oral ulceration Stomatitis (1987):
- Page 442 and 443: Reactions Skin Erythema multiforme
- Page 444 and 445: (1996): Carrington PR, Little Rock,
- Page 446 and 447: (2003): Abe M+, Intern Med 42(1), 4
- Page 448 and 449: Other Abdominal pain (2006): Preutt
- Page 450 and 451: Erythema multiforme Exanthems (9-16
- Page 452 and 453: Other Anaphylactoid reactions/Anaph
- Page 454 and 455: MUPIROCIN* Trade names: Bactoderm;
- Page 456 and 457: Mucosal Gingivitis (
- Page 458 and 459: (1981): Wolf A, ZHautkr(German) 56,
- Page 460 and 461: (1984): Stern RS+, JAMA 252, 1433 V
- Page 462 and 463: Hair Hair - alopecia (
Other<br />
Abdominal pain (7%)<br />
Cough (1%)<br />
Fever (1%)<br />
Myalgia/Myositis/Myopathy/Myotoxicity (1%)<br />
Pain (~0.2%)<br />
Upper respiratory infection (4%)<br />
LUMIRACOXIB<br />
Trade name: Prexige (Novartis)<br />
Indications: Osteoarthritis<br />
Category: COX-2 selective inhibitor NSAID<br />
Half-life: 4 hours<br />
Clinically important, potentially hazardous interactions<br />
with: aspirin. other NSAIDs<br />
Reactions<br />
Skin<br />
Angioedema<br />
Exfoliative dermatitis<br />
Peripheral edema (2%)<br />
Stevens–Johnson syndrome<br />
Toxic epidermal necrolysis<br />
Other<br />
Abdominal pain (1%)<br />
Anaphylactoid reactions/Anaphylaxis<br />
Cough (2%)<br />
Hepatotoxicity<br />
Myalgia/Myositis/Myopathy/Myotoxicity (1.5%)<br />
LUTROPIN ALFA<br />
Trade name: Luveris (Merck)<br />
Indications: Infertility<br />
Category: Hormone modulator; Luteinizing hormone<br />
Half-life: ~14 hours<br />
Skin<br />
Edema<br />
Erythema<br />
Pruritus<br />
Rash (sic)<br />
Urticaria<br />
Vesiculation<br />
Xerosis<br />
Hair<br />
Hair – alopecia<br />
Other<br />
Abdominal pain (5–8%)<br />
Chills<br />
Fever<br />
Gynecomastia<br />
Injection-site edema<br />
Injection-site irritation<br />
Injection-site pain<br />
Reactions<br />
Injection-site reactions (3–4%)<br />
Upper respiratory infection (1–2%)<br />
LYCOPENE<br />
Scientific names: All-Trans-Lycopene; Psi-Psi-Carotene<br />
Trade <strong>and</strong> other common names: Carotenoid; Lyc-O-Mato;<br />
Lycovit (BASF)<br />
Category: Antioxidant<br />
Purported indications <strong>and</strong> other uses: Cancer (prevention),<br />
cardiovascular disease (prevention), asthma<br />
Half-life: N/A<br />
Note: Cooking increases bioavailability of lycopene. Major dietary<br />
sources are tomato paste, juice, <strong>and</strong> ketchup<br />
Reactions<br />
Skin<br />
Pigmentation<br />
(2003): Saldana Chaparro RS+, Ann Clin Biochem 40(Pt 3), 280<br />
MAFENIDE*<br />
Trade name: Sulfamylon<br />
Indications: Second- <strong>and</strong> third-degree burns<br />
Category: Antiseptic; Sulfonamide<br />
Half-life: N/A<br />
Clinically important, potentially hazardous interactions<br />
with: None<br />
*Note: Mafenide is a sulfonamide <strong>and</strong> can be absorbed systemically.<br />
Sulfonamides can produce severe, possibly fatal, reactions such as<br />
toxic epidermal necrolysis <strong>and</strong> Stevens–Johnson syndrome<br />
Reactions<br />
MAFENIDE 339<br />
Skin<br />
Allergic reactions (sic)<br />
(1995): McKenna SR+, Burns 21(4), 310<br />
Bullous dermatitis<br />
Burning<br />
Dermatitis<br />
(1993): Sanz de Galdeano C+, Contact Dermatitis 28(4), 249<br />
(1992): Fern<strong>and</strong>ez JC+, Contact Dermatitis 27(4), 262<br />
Edema<br />
Erythema<br />
Excoriations<br />
Facial edema<br />
Pruritus (2.8%)<br />
(1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158<br />
Rash (sic) (4.6%)<br />
(1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158<br />
Other<br />
Anaphylactoid reactions/Anaphylaxis<br />
Application-site burning<br />
Death<br />
Hypersensitivity<br />
(1988): Perry AW+, J Burn Care Rehabil 9(2), 145<br />
Pain<br />
(1993): Kucan JO+, J Burn Care Rehabil 14(2 Pt 1), 158<br />
Porphyria
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