Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

338 LOVASTATIN
Hair
Hair – alopecia (>1%)
Other
Gynecomastia (1–10%)
(1999): Stein EA+, JAMA 281, 137
Hepatotoxicity
(2007): Stein CA+, Invest New Drugs 25(3), 277 (with
ketoconazole)
Hypersensitivity
Myalgia/Myositis/Myopathy/Myotoxicity (1–10%)
(2005): Wortmann RL+, Am J Cardiol 95(8), 983 (low)
(1995): Garnett WR, Am J Health Syst Pharm 52(15), 1639
(1990): Kogan AD+, Postgrad Med J 66, 294
(1989): Vaher VMG+, Lancet 2, 1098
Pseudolymphoma
(1996): Magro CM+, Hum Pathol 27(2), 125
Rhabdomyolysis
(2007): Stein CA+, Invest New Drugs 25(3), 277 (with
ketoconazole)
(2005): Wortmann RL+, Am J Cardiol 95(8), 983 (low)
(2000): Davidson MH, Curr Atheroscler Rep 2(1), 14
(1999): Bottorff M, Atherosclerosis 147(Suppl 1), S23
(1999): Corsini A+, Pharmacol Ther 84, 413 (with cyclosporine,
mibefradil or nefazodone)
(1998): Reaven P+, AnnInternMed109, 597 (with nicotinic acid)
(1998): Tobert JA+, Am J Cardiol 62, 28J (with gemfibrozil)
(1998): Wong PW+, South Med J 91(2), 202 (with erythromycin)
(1997): Chu PH+, Jpn Heart J 38(4), 541
(1997): Grunden JW+, Ann Pharmacother 31(7), 859 (with
azithromycin and clarithromycin)
(1997): Hermida Lazcano I+, An Med Interne 14, 488
(1997): Olbricht C+, Clin Pharmacol Ther 62(3), 311 (with
cyclosporine)
(1996): Ballantyne CM+, Am J Cardiol 78(5), 532
(1996): Biesenbach G+, Wien Klin Wochenschr 108(11), 334
(1995): Abdul-Ghaffar NU+, J Clin Gastroenterol 21(4), 340
(with gemfibrozil)
(1995): Farmer JA+, Baillieres Clin Endocrinol Metab 9(4), 825
(1995): Garnett WR, Am J Health Syst Pharm 52(15), 1639 (with
cyclosporine, gemfibrozil or niacin)
(1995): Lees RS+, NEnglJMed333(10), 664 (with itraconazole)
(1994): Alejandro DS+, JAmSocNephrol5(2), 153 (with
cyclosporine)
(1994): Dallaire M+, CMAJ 150(12), 1991 (with danazol)
(1993): Knoll RW+, Conn Med 57(9), 593 (with gemfibozil)
(1992): Chan PC+, NephrolDialTransplant7(2), 93
(1992): Chrysanthopoulos C+, BMJ 304(6836), 1225 (with
cholestyramine)
(1992): Hume AL, Ann Pharmacother 26(10), 1303
(1992): Wallace CS+, Ann Pharmacother 26(2), 190
(1991): Spach DH+, West J Med 154(2), 213 (with
erythromycin)
(1991): Sylvain-Moore H+, Heart Lung 20(5 Pt 1), 464
(1990): JAMA 264(23), 2991 (with gemfibrozil)
(1990): Kogan AD+, Postgrad Med J 66(774), 294
(1990): Manoukian AA+, Clin Chem 36(12), 2145
(1990): Marais GE+, AnnInternMed112(3), 228 (with
gemfibrozil)
(1990): Pierce LR+, JAMA 264(1), 71 (with gemfibrozil)
(1990): Tobert JA+, Am J Cardiol 65(Suppl), 23F
(1988): Corpier CL+, JAMA 260(2), 239 (cyclosporine)
(1988): Reaven P+, AnnInternMed109(7), 597
(1988): Tobert JA+, Am J Cardiol 62, 28J (with cyclosporine)
LOXAPINE
Trade names: Desconex; Loxapac; Loxitane (Watson)
Indications: Psychoses
Category: Antipsychotic, tricyclic
Half-life: 12–19 hours (terminal)
Reactions
Skin
Dermatitis
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin
Blackwell, Oxford, 203 (passim)
Diaphoresis
Exanthems
Facial edema
Photosensitivity (