Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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336 LORATADINE LORATADINE Trade names: Alavert (Wyeth); Civeran; Claratyne; Claritin (Schering); Claritin-D (Schering); Claritine; Lisino; Lorastine; Velodan; Zeos Indications: Allergic rhinitis, urticaria Category: Histamine H1 receptor antagonist Half-life: 3–20 hours Reactions Skin Angioedema (>2%) (1989): Clissold SP+, Drugs 37, 42 Dermatitis (>2%) Diaphoresis (>2%) Erythema multiforme (>2%) Exanthems Fixed eruption (2003): Pionetti CH+, Allergol Immunopathol (Madr) 31(5), 291 (2002): Ruiz-Genao DP+, Br J Dermatol 146(3), 528 Peripheral edema (>2%) Photosensitivity (>2%) Pruritus (>2%) (1989): Barenholtz HA+, Drug Intell Clin Pharm 23, 445 Purpura (>2%) Rash (sic) (>2%) Urticaria (>2%) (1992): Boner AL+, Allergy 47, 98 (1989): Clissold SP+, Drugs 37, 42 Xerosis (>2%) Mucosal Sialorrhea (>2%) Stomatitis (>2%) Vaginitis (>2%) Xerostomia (>10%) (1993): Pacor ML+, Clin Ter 1993 Jun 142(6), 529 (2%) (1992): Monroe EW+, Arzneimittelforschung (German) 42, 1119 (1992): Olson OT+, Arzneimittelforschung (German) 42, 1227 (1990): Del Carpio J+, J Allergy Clin Immunology 84, 741 (1990): Irander K+, Allergy 45, 86 (1990): Simons FE, Clin Exp Allergy 20, 19 (1989): Barenholtz HA+, Drug Intell Clin Pharm 23, 445 (1989): Bruttman G+, J Allergy Clin Immunology 83, 411 (1988): Gutkowski A+, J Allergy Clin Immunology 81, 902 Hair Hair – alopecia (>2%) Hair – dry (>2%) Other Anaphylactoid reactions/Anaphylaxis (>2%) Gynecomastia (>2%) Myalgia/Myositis/Myopathy/Myotoxicity (>2%) LORAZEPAM Trade names: Apo-Lorazepam; Ativan (Wyeth) (Baxter); Durazolam; Laubeel; Merlit; Nu-Loraz; Punktyl; Tavor; Temesta; Titus Indications: Anxiety, depression Category: Benzodiazepine Half-life: 10–20 hours Clinically important, potentially hazardous interactions with: alcohol, amprenavir, barbiturates, chlorpheniramine, clarithromycin, CNS depressants, efavirenz, erythromycin, esomeprazole, imatinib, MAO inhibitors, narcotics, nelfinavir, phenothiazines, valproate Reactions Skin Dermatitis (1–10%) Diaphoresis (>10%) Erythema multiforme (1991): Porteous DM+, Arch Dermatol 127, 741 Exanthems Fixed eruption (1988): Jafferany M+, Dermatologica 177, 386 Pruritus Purpura Rash (sic) (>10%) Stevens–Johnson syndrome (1991): Porteous DM+, Arch Dermatol 127, 741 Urticaria Mucosal Gingival lichenoid reaction (1986): Colvard MD+, Periodont Case Rep 8, 69 Sialopenia (>10%) Sialorrhea (10%) Hair Hair – alopecia Hair – hirsutism Other Injection-site pain (>10%) (1981): Ameer B+, Drugs 21, 161 (7–52%) Injection-site phlebitis (>10%) (1981): Clarke RSJ, Drugs 22, 26 (15%) Pseudolymphoma (1995): Magro CM+, JAmAcadDermatol32, 419 (1988): Kardaun SH+, Br J Dermatol 118(4), 545 Rhabdomyolysis (1983): Cauana RJ+, NCMedJ44, 18 (with amitriptyline and perphenazine) LOSARTAN Synonyms: DuP 753; MK 594 Trade names: Cozaar (Merck); Hyzaar (Merck) Indications: Hypertension Category: Angiotensin II receptor antagonist Half-life: 2 hours Hyzaar is losartan and hydrochlorothiazide

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