Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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(2002): Kalin JR+, JForensicSci47(5), 1135 (overdose) (2002): Nisse P+, Acta Clin Belg Suppl 1, 51 Embolia cutis medicamentosa (Nicolau syndrome) (1990): Wand A+, Aktuel Dermatol (German) 16, 128 Hypersensitivity (2006): Hickey JR+, Contact Dermatitis 54(4), 215 (2003): Mackley CL+, Arch Dermatol 139(3), 343 (1998): Marks JG+, JAmAcadDermatol38(6), 911 (1996): Bircher AJ+, Contact Dermatitis 34, 387 (1996): Whalen JD+, Arch Dermatol 132, 1256 (1991): Klein CE+, Contact Dermatitis 25(1), 45 Injection-site pain Injection-site phlebitis LINCOMYCIN Trade names: Albiotic; Cillimicina; Cillimycin; Lincocin (Pfizer); Lincocine; Princol; Zumalin Indications: Various infections caused by susceptible organisms Category: Antibiotic, lincosamide Half-life: 2–11.5 hours Reactions Skin Acute generalized exanthematous pustulosis (2005): Otsuka A+, JDermatol32(11), 929 (2003): Valois M+, Contact Dermatitis 48(3), 169 Allergic reactions (sic) (1–5%) Angioedema Dermatitis (1991): Vilaplana J+, Contact Dermatitis 24, 225 (1985): Conde-Salazar L+, Contact Dermatitis 12, 59 (erythema multiforme-like) Erythema multiforme Exanthems Exfoliative dermatitis Photosensitivity Pruritus Pruritus ani et vulvae (

330 LINDANE (1989): Vercel M+, Cah Anesthesiol 37(7), 543 (1988): Sunder Ram Rao CV+, Vet Hum Toxicol 30(2), 132 (1985): American Hospital Formulary Service-Drug Information 85, 1601 (1984): Gosselin RE+, Clinical Toxicology of Commercial Products 5th ed, III–239 (1983): Davies JE+, Arch Dermatol 119(2), 142 (1982): Telch J+, Can Med Assoc 126(6), 662 (1982): Telch J+, Can Med Assoc 127(9), 821 (1980): Powell GM, Cent Afr J Med 26(7), 170 (1980): Rasmussen JE, Arch Dermatol 116(11), 1226 Neurotoxicity (2006): Prescrire Int 15(82), 61 (2006): Singal A+, Am J Ther 13(3), 277 Rhabdomyolysis (1988): Sunder Ram Rao CV+, Vet Hum Toxicol 30(2), 132 (1984): Jaeger U+, Vet Hum Toxicol 26(1), 11 LINEZOLID Trade name: Zyvox (Pfizer) Indications: Various infections caused by susceptible organisms Category: Antibiotic, oxazolidinone Half-life: 4–5 hours Clinically important, potentially hazardous interactions with: amitriptyline, amoxapine, clomipramine, desipramine, dextromethorphan, doxepin, fluoxetine, fluvoxamine, imipramine, meperidine, nortriptyline, paroxetine, protriptyline, sertraline, sibutramine, trazodone, tricyclic antidepressants, trimipramine, venlafaxine Reactions Skin Adverse effects (sic) (4%) (2003): Birmingham MC+, Clin Infect Dis 36(2), 159 (4%) Allergic reactions (sic) (4%) (2003): Birmingham MC+, Clin Infect Dis 36(2), 159 (4%) Exanthems (2006): Borras-Blasco J+, Int J Clin Pharmacol Ther 44(7), 331 (generalized) Fungal dermatitis (0.1–2%) Pruritus Rash (sic) (2%) (2005): Aneziokoro CO+, JChemother17(6), 643 (5%) Mucosal Candidal vaginitis (1–2%) Oral candidiasis (

330 LINDANE<br />

(1989): Vercel M+, Cah Anesthesiol 37(7), 543<br />

(1988): Sunder Ram Rao CV+, Vet Hum Toxicol 30(2), 132<br />

(1985): American Hospital Formulary Service-<strong>Drug</strong> Information<br />

85, 1601<br />

(1984): Gosselin RE+, Clinical Toxicology of Commercial Products<br />

5th ed, III–239<br />

(1983): Davies JE+, Arch Dermatol 119(2), 142<br />

(1982): Telch J+, Can Med Assoc 126(6), 662<br />

(1982): Telch J+, Can Med Assoc 127(9), 821<br />

(1980): Powell GM, Cent Afr J Med 26(7), 170<br />

(1980): Rasmussen JE, Arch Dermatol 116(11), 1226<br />

Neurotoxicity<br />

(2006): Prescrire Int 15(82), 61<br />

(2006): Singal A+, Am J Ther 13(3), 277<br />

Rhabdomyolysis<br />

(1988): Sunder Ram Rao CV+, Vet Hum Toxicol 30(2), 132<br />

(1984): Jaeger U+, Vet Hum Toxicol 26(1), 11<br />

LINEZOLID<br />

Trade name: Zyvox (Pfizer)<br />

Indications: Various infections caused by susceptible organisms<br />

Category: Antibiotic, oxazolidinone<br />

Half-life: 4–5 hours<br />

Clinically important, potentially hazardous interactions<br />

with: amitriptyline, amoxapine, clomipramine, desipramine,<br />

dextromethorphan, doxepin, fluoxetine, fluvoxamine,<br />

imipramine, meperidine, nortriptyline, paroxetine, protriptyline,<br />

sertraline, sibutramine, trazodone, tricyclic antidepressants,<br />

trimipramine, venlafaxine<br />

Reactions<br />

Skin<br />

Adverse effects (sic) (4%)<br />

(2003): Birmingham MC+, Clin Infect Dis 36(2), 159 (4%)<br />

Allergic reactions (sic) (4%)<br />

(2003): Birmingham MC+, Clin Infect Dis 36(2), 159 (4%)<br />

Exanthems<br />

(2006): Borras-Blasco J+, Int J Clin Pharmacol Ther 44(7), 331<br />

(generalized)<br />

Fungal dermatitis (0.1–2%)<br />

Pruritus<br />

Rash (sic) (2%)<br />

(2005): Aneziokoro CO+, JChemother17(6), 643 (5%)<br />

Mucosal<br />

C<strong>and</strong>idal vaginitis (1–2%)<br />

Oral c<strong>and</strong>idiasis (

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