Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

316 KETOTIFEN
(1982): Simons FE+, Ann Allergy 48(3), 145
Eyes
Ocular burning (1–10%)
(2003): Ganz M+, Adv Ther 20(2), 79
Ocular stinging (1–10%)
Xerophthalmia (1–10%)
L-CARNITINE
Trade names: Acetyl-L-carnitine; Aplegin; B(t)Factor; Carnitine;
Carnitor; L-Carnipure; Levocarnitine; Propionyl-L-carnitine;
Vitacarn; Vitamin B(t)
Indications: Improves lipid metabolism, red blood cell count,
and antioxidant status, chronic fatigue syndrome, dementia,
angina, post-MI cardioprotection, congestive heart failure,
valproate toxicity, anorexia
Category: Food supplement
Half-life: N/A
Clinically important, potentially hazardous interactions
with: None
None
Reactions
Note: Mixed D, L-carnitine has been associated with myasthenic
syndrome.
LABETALOL
Trade names: Abetol; Amipress; Hybloc; Ipolab; Labrocol;
Normozide; Presolol; Salmagne; Trandate (Prometheus)
Indications: Hypertension
Category: Adrenergic beta-receptor antagonist; Antiarrhythmic
class II
Half-life: 3–8 hours
Normozide is labetalol and hydrochlorothiazide
Note: Cutaneous side effects of beta-receptor blockaders are
clinically polymorphous. They apparently appear after several months
of continuous therapy. Atypical psoriasiform, lichen planus-like, and
eczematous chronic rashes are mainly observed. (1983): Hödl St, Z
Hautkr (German) 1:58, 17
Reactions
Skin
Angioedema
(1986): Ferree CE, AnnInternMed104, 729
Dermatitis
(1990): Bause GS+, Contact Dermatitis 23, 51
Diaphoresis (