Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

314 KETOCONAZOLE
Nails
Nails – pigmentation
(1985): Dreessen K, ZHautkr(German) 60, 679 (black
longitudinal bands)
Other
Anaphylactoid reactions/Anaphylaxis
(2005): Liu PY+, Ann Pharmacother 39(3), 547
(1994): Gupta AK+, JAmAcadDermatol30, 677 (passim)
(1983): van Dijke CPH+, BMJ 287, 1673
Chills (1–3%)
Death
(2001): Duman D+, Am J Med 111(9), 737
(1994): Sella A+, J Clin Oncol 12(4), 683 (with doxorubicin)
Gynecomastia (1–3%)
(1994): Gupta AK+, JAmAcadDermatol30, 677 (passim)
(1993): Thompson DF+, Pharmacotherapy 13, 37
(1982): Moncada B, JAmAcadDermatol7, 557
(1981): DeFelice R+, Antimicrob Agents Chemo 19, 1073
Hepatotoxicity
(2007): Stein CA+, Invest New Drugs 25(3), 277 (with lovastatin)
Hypersensitivity
(1994): Gonzalez-Delgado P+, Ann Allergy 73, 326
(1992): Verschueren GL+, Contact Dermatitis 26, 47
(1989): Garcia-Bravo B+, Contact Dermatitis 21, 346
Myalgia/Myositis/Myopathy/Myotoxicity
(1991): Garty BZ+, Am J Dis Child 145, 970
Rhabdomyolysis
(2007): Akram K+, Int J Cardiol 118(1), e19 (with simvastatin)
(2007): Stein CA+, Invest New Drugs 25(3), 277 (with lovastatin)
(1999): Gilad R+, Clin Neuropharmacol 22(5), 295 (with
simvastatin)
KETOPROFEN
Trade names: Alrheumat; Alrheumun; Aneol; Bi-Profenid;
Gabrilen Retard; Keduril; Novo-Keto; Orudis (Sanofi-Aventis);
Oruvail (Wyeth); Rhodis; Rhovail
Indications: Arthritis
Category: Non-steroidal anti-inflammatory
Half-life: 1.5–4 hours
Clinically important, potentially hazardous interactions
with: aspirin, methotrexate, probenecid
Reactions
Skin
Allergic reactions (sic) (