Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Serum sickness (1998): Park H+, Ann Pharmacother 32, 1249 IVERMECTIN Trade name: Stromectol (Merck) Indications: Various infections caused by susceptible helmintic organisms Category: Antihelmintic Half-life: 16–35 hours Clinically important, potentially hazardous interactions with: alprazolam, barbiturates, benzodiazepines, diazepam, midazolam, valproic acid Reactions Skin Angioedema (2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with praziquantel and albendazole) Bullous dermatitis (1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313 Bullous pemphigoid (2001): Trindade P, Natal, Brazil (personal communication) Burning (1999): Editorial, Arch Dermatol 135, 705 Dermatitis (1999): Editorial, Arch Dermatol 135, 705 Edema (10–53%) (1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143 (1995): Darge K+, Trop Med Parasitol 46, 206 (arms and legs) (10%) (1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313 (1992): Chijioke CP+, Trans R Soc Trop Med Hyg 86, 284 (1992): Collins RC+, Am J Trop Med Hyg 47, 156 (facial) (31.8%) (1992): Zea-Flores R+, Trans R Soc Trop Med Hyg 86, 663 (53%) (1991): Bryan RT+, Lancet 337, 304 (1991): Guderian RH+, Lancet 337, 188 (leg) Exanthems (1–34%) (1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313 (1991): Whitworth JAG+, Lancet 337, 625 (1–5%) (1990): Ette EI+, Drug Intell Clin Pharm 24, 426 (34%) Facial edema (1.2%) (1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143 (1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313 Peripheral edema Pruritus (38%–71%) (2005): Nontasut P+, Southeast Asian J Trop Med Public Health 36(2), 442 (1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143 (1995): Darge K+, Trop Med Parasitol 46, 206 (1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313 (1993): Kar SK+, Acta Trop 55, 21 (1992): Chijioke CP+, Trans R Soc Trop Med Hyg 86, 284 (71.2%) (1992): Collins RC+, Am J Trop Med Hyg 47, 156 (34%) (1991): Bryan RT+, Lancet 337, 304 (1991): Whitworth JAG+, Lancet 337, 625 (8%) (1990): Ette EI+, Drug Intell Clin Pharm 24, 426 (9.6%) (1989): Guderian RH+, Eur J Epidemiol 5, 294 (4%) Pustules Rash (sic) (1–93%) (1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143 (1993): Kar SK+, Acta Trop 55, 21 (1991): Bryan RT+, Lancet 337, 304 (93%) (1991): Guderian RH+, Lancet 337, 188 (1991): Whitworth JAG+, Lancet 337, 625 (8%) (1989): Guderian RH+, Eur J Epidemiol 5, 294 (4%) Side effects (sic) (mild) (2002): Prescrire Int 11(61), 137 Urticaria (0.9–22.7%) (2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with praziquantel and albendazole) Other Abdominal pain (2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with praziquantel and albendazole) Fever (2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with praziquantel and albendazole) (2004): Pani SP+, JCommunDis36(4), 240 Myalgia/Myositis/Myopathy/Myotoxicity (20%) (2004): Pani SP+, JCommunDis36(4), 240 (1995): Darge K+, Trop Med Parasitol 46, 206 (20%) (1993): Kar SK+, Acta Trop 55, 21 JOJOBA OIL Scientific names: Buxus chinensis; Simmondsia chinensis Family: Simmondsiaceae Trade and other common names: Coffeebush; Deer-nut; Goat-nut; Pig-nut Purported indications and other uses: Moisturizer in cosmetics and hair care products, edible oil Half-life: N/A Clinically important, potentially hazardous interactions with: N/A Reactions Skin Dermatitis (2006): Di Berardino+, Contact Dermatitis 55(1), 57 (1996): Wantke F+, Contact Dermatitis 34(1), 71 JUNIPER Scientific names: Juniperus communis; Juniperus oxycedrus; Juniperus phoenicea; Juniperus virginiana Family: Cupressaceae Trade and other common names: Baccae Juniperi; Cade Oil; Enebro; Gemeiner Wachholder; Genevrier; Ginepro; Juniper Tar Oil; Zimbro Category: Anti-inflammatory Purported indications and other uses: Cystitis, urethritis, urinary tract infections, flatulent colic, rheumatism, arthritis, gout, leucorrhea, blenorrhea, scrofula. Topical: joint pain, muscle pain, neuralgia, chronic eczema. Inhalant: bronchitis, lung infections. Condiment, flavor component (gin, Chartreuse, bitters), perfume Half-life: N/A Clinically important, potentially hazardous interactions with: loop diuretics, spironolactone, thiazide diuretics, triamterene Skin Allergic reactions (sic) Reactions JUNIPER 311
312 JUNIPER Dermatitis (1996): Meding B+, Contact Dermatitis 34(3), 185 Edema Erythema Sensitivity (sic) (2001): Int J Toxicol 20, 41 Vesiculation KANAMYCIN Trade names: Kanamicina; Kanamycine; Kanamytrex; Kanescin; Kannasyn; Kantrex; Randikan Indications: Various infections caused by susceptible organisms Category: Antibiotic, aminoglycoside Half-life: 2–4 hours Clinically important, potentially hazardous interactions with: aldesleukin, atracurium, bumetanide, doxacurium, ethacrynic acid, furosemide, methoxyflurane, non-depolarizing muscle relaxants, pancuronium, polypeptide antibiotics, rocuronium, succinylcholine, torsemide, vecuronium Reactions Skin Burning Dermatitis (systemic) (1986): Holdiness MR, Contact Dermatitis 15, 282 Edema (>10%) Erythema (
Page 1:
Litt’s Drug Eruption rEfErEncE Ma
Page 6 and 7:
CONTENTS Introduction vii Index of
Page 8 and 9:
INTRODUCTION Any drug can cause any
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A plus sign (+) after the authors n
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INDEX OF GENERIC AND TRADE NAMES Ad
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INDEX OF GENERIC AND TRADE NAMES am
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INDEX OF GENERIC AND TRADE NAMES as
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INDEX OF GENERIC AND TRADE NAMES Be
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INDEX OF GENERIC AND TRADE NAMES ca
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INDEX OF GENERIC AND TRADE NAMES ci
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INDEX OF GENERIC AND TRADE NAMES Cy
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INDEX OF GENERIC AND TRADE NAMES Di
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INDEX OF GENERIC AND TRADE NAMES Du
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INDEX OF GENERIC AND TRADE NAMES Et
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INDEX OF GENERIC AND TRADE NAMES FU
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INDEX OF GENERIC AND TRADE NAMES Hi
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INDEX OF GENERIC AND TRADE NAMES Is
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INDEX OF GENERIC AND TRADE NAMES Le
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INDEX OF GENERIC AND TRADE NAMES Me
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INDEX OF GENERIC AND TRADE NAMES Mo
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INDEX OF GENERIC AND TRADE NAMES Ni
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INDEX OF GENERIC AND TRADE NAMES Op
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INDEX OF GENERIC AND TRADE NAMES pe
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INDEX OF GENERIC AND TRADE NAMES Pr
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INDEX OF GENERIC AND TRADE NAMES Re
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INDEX OF GENERIC AND TRADE NAMES Si
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INDEX OF GENERIC AND TRADE NAMES Sy
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INDEX OF GENERIC AND TRADE NAMES to
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INDEX OF GENERIC AND TRADE NAMES Ur
Page 63 and 64:
INDEX OF GENERIC AND TRADE NAMES Xo
Page 65 and 66:
INDEX OF HERBALS Cola acuminata caf
Page 67 and 68:
INDEX OF HERBS Smilax regelii sarsa
Page 69 and 70:
MAIN CLASSES OF DRUGS ACE inhibitor
Page 71 and 72:
Antiplatelet abciximab aspirin cilo
Page 73 and 74:
MAIN CLASSES OF DRUGS Histamine H1
Page 76 and 77:
ABACAVIR Trade names: Trizivir (GSK
Page 78 and 79:
Xerostomia (2%) Hair Hair - alopeci
Page 80 and 81:
(2006): Santoro D+, Clin Nephrol 66
Page 82 and 83:
Exanthems (2-25%) (1999): Katz HI+,
Page 84 and 85:
ADALIMUMAB Synonym: D2E7 Trade name
Page 86 and 87:
ALBENDAZOLE Trade names: ABZ; Alben
Page 88 and 89:
(2003): Chodorowska G+, Ann Univ Ma
Page 90 and 91:
ALFENTANIL Trade names: Alfenta (Ak
Page 92 and 93:
Lupus erythematosus (1980): Condemi
Page 94 and 95:
Other Abdominal pain (2005): Turgeo
Page 96 and 97:
(1982): van Ketel WG, Contact Derma
Page 98 and 99:
Exanthems Photosensitivity (1984):
Page 100 and 101:
(1980): Lawyer CH+, J Allergy Clin
Page 102 and 103:
Purpura (2%) (1983): Fogoros RN+, C
Page 104 and 105:
(2006): Piller LB+, J Clin Hyperten
Page 106 and 107:
(2006): Gonzalez-Delgado P+, Allerg
Page 108 and 109:
Chills (2004): Martino R, Curr Med
Page 110 and 111:
AMPRENAVIR* Trade name: Agenerase (
Page 112 and 113:
(2001): Ahrendt DM, Am Fam Physicia
Page 114 and 115:
(1999): Ellenberg SS, Center for Bi
Page 116 and 117:
(1996): Martinelli L+, Ann Thorac S
Page 118 and 119:
(2003): Uede K+, Br J Dermatol 149(
Page 120 and 121:
ARTEMISIA Scientific names: Artemis
Page 122 and 123:
ASPIRIN Synonyms: acetylsalicylic a
Page 124 and 125:
ATAZANAVIR Trade name: Reyataz (Bri
Page 126 and 127:
(1999): Oakley A, Hamilton, New Zea
Page 128 and 129:
(2002): Robenshtok E+, Isr Med Asso
Page 130 and 131:
Scleroderma (1993): Choy E+, Br J R
Page 132 and 133:
(1997): Epstein ME+, JAmAcadDermato
Page 134 and 135:
Hair Hair - hypertrichosis (3-10%)
Page 136 and 137:
(1997): Banac S+, Acta Paediatr 86(
Page 138 and 139:
BENZALKONIUM Synonyms: parasterol;
Page 140 and 141:
(2002): Gruson LM+, Arch Pediatr Ad
Page 142 and 143:
(2000): Bedikian AY+, Oncol Rep 7,
Page 144 and 145:
BISMUTH Trade names: Bismatrol; Bis
Page 146 and 147:
BLEOMYCIN Synonyms: bleo; BLM Trade
Page 148 and 149:
BLOODROOT Scientific name: Sanguina
Page 150 and 151:
Punctate keratitis (2004): Northing
Page 152 and 153:
BROMFENAC Trade name: Xibrom (ISTA
Page 154 and 155:
Erythema multiforme (
Page 156 and 157:
Myalgia/Myositis/Myopathy/Myotoxici
Page 158 and 159:
(1989): Ackerman WE+, Can J Anaesth
Page 160 and 161:
CALFACTANT Trade name: Infasurf (Fo
Page 162 and 163:
CAPSICUM Scientific names: Capsicum
Page 164 and 165:
Lupus erythematosus (2002): Ratliff
Page 166 and 167:
Corneal edema Eyelid twitching Kera
Page 168 and 169:
Stevens-Johnson syndrome (1-10%) (2
Page 170 and 171:
Porphyria variegata (2001): Grieco
Page 172 and 173:
(1983): Rollings HE+, Curr Ther Res
Page 174 and 175:
Dermatitis (1986): Hirata M+, Kokyu
Page 176 and 177:
Other Anaphylactoid reactions/Anaph
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Candidiasis (
Page 184 and 185:
Herpes zoster (
Page 186 and 187:
Hypersensitivity Injection-site pai
Page 188 and 189:
Other Abdominal pain (25%) Anaphyla
Page 190 and 191:
CHLORAMBUCIL Trade names: Chloramin
Page 192 and 193:
(1992): Ramselaar CG+, Br J Urol 70
Page 194 and 195:
(1997): Selvaag E, Ann Trop Pediatr
Page 196 and 197:
(1989): Rosen C, Semin Dermatol 8,
Page 198 and 199:
CHOLESTYRAMINE Trade names: Chol-Le
Page 200 and 201:
CIMETIDINE Trade names: Apo-Cimetid
Page 202 and 203:
(2000): Sharobeem KM+, J Cardiovasc
Page 204 and 205:
(1997): Carrasco JM+, Ann Pharmacot
Page 206 and 207:
CITALOPRAM Synonym: nitalapram Trad
Page 208 and 209:
CLEMASTINE Trade names: Aller-Eze;
Page 210 and 211:
Other Hypersensitivity (2002): Somm
Page 212 and 213:
CLOMIPRAMINE Trade names: Anafranil
Page 214 and 215:
CLOPIDOGREL Trade name: Plavix (Bri
Page 216 and 217:
Eczema (
Page 218 and 219:
(1997): Thaler D, Monona, WI (from
Page 220 and 221:
COCOA Scientific names: Theobroma c
Page 222 and 223:
COLESEVELAM Trade name: Welchol (Sa
Page 224 and 225:
CORDYCEPS Scientific name: Cordycep
Page 226 and 227:
CYCLAMATE Trade name: Sucaryl (Abbo
Page 228 and 229:
Inappropriate secretion of antidiur
Page 230 and 231:
(1996): Cox NH, Clin Exp Dermatol 2
Page 232 and 233:
(2007): Lim AK+, Intern Med J 37(1)
Page 234 and 235:
(1989): Kerker BJ+, Semin Dermatol
Page 236 and 237:
Pruritus (1-10%) Rash (sic) (1-10%)
Page 238 and 239:
(1988): Tham SN+, Singapore Med J 2
Page 240 and 241:
DASATINIB Synonym: BMS354825 Trade
Page 242 and 243:
Page 244 and 245:
(1980): Miescher PA+, Clin Haematol
Page 246 and 247:
(1985): Job JC+, Arch Fr Pediatr 42
Page 248 and 249:
DEXTROMETHORPHAN Trade names: Balmi
Page 250 and 251:
Erythema nodosum (
Page 252 and 253:
Mucosal Oral ulceration Hair Hair -
Page 254 and 255:
(1987): Masden JJ+, Curr Ther Res 4
Page 256 and 257:
(1998): Knowles S+, JAmAcadDermatol
Page 258 and 259:
Epiphora Other Abdominal pain Fever
Page 260 and 261:
DISOPYRAMIDE Trade names: Dimodan;
Page 262 and 263:
(1995): Cortes JE+, J Clin Oncol 13
Page 264 and 265:
DOMPERIDONE Trade names: Evoxin; Mo
Page 266 and 267:
DOXAPRAM Trade name: Dopram (Baxter
Page 268 and 269:
(1989): Jones AP+, Br J Cancer 59,
Page 270 and 271:
(1992): Bennett MJ, JRArmyMedCorps1
Page 272 and 273:
ECHINACEA Scientific names: Echinac
Page 274 and 275:
Hot flashes (
Page 276 and 277:
Pemphigus vegetans (1994): Bastiaen
Page 278 and 279:
Stevens-Johnson syndrome (
Page 280 and 281:
Ocular pruritus (1-10%) Other Cough
Page 282 and 283:
(2002): Bohm M+, Drug Saf 25(8), 59
Page 284 and 285:
Pustules (1993): Manu Shah R+, Eur
Page 286 and 287:
ESTAZOLAM Trade names: Domnamid; Es
Page 288 and 289:
Allergic reactions (sic) Cellulitis
Page 290 and 291:
Exanthems Photosensitivity Purpura
Page 292 and 293:
Other Anticonvulsant hypersensitivi
Page 294 and 295:
ETORICOXIB Trade names: Algix; Arco
Page 296 and 297:
Purpura (1996): Kallal SM+, West J
Page 298 and 299:
(1980): Couzigou P+, Therapie 35(3)
Page 300 and 301:
FINASTERIDE Trade names: Pro-Cure;
Page 302 and 303:
(1991): Abbott M+, Lancet 2, 633 Bu
Page 304 and 305:
FLUOCINOLONE Trade names: Capex (Ga
Page 306 and 307:
(2003): Salim A+, Br J Dermatol 148
Page 308 and 309:
Erythema multiforme (1985): Wernick
Page 310 and 311:
Injection-site reactions Rhabdomyol
Page 312 and 313:
Toxic epidermal necrolysis Urticari
Page 314 and 315:
Reactions Skin Angioedema Erythema
Page 316 and 317:
Reactions Skin Acne (
Page 318 and 319:
Thrombophlebitis *Note: Furosemide
Page 320 and 321:
GANCICLOVIR Trade names: Cymevan; C
Page 322 and 323:
(2002): Baselga J+, J Clin Oncol 20
Page 324 and 325:
(2003): D’Alessandro V+, Clin Ter
Page 326 and 327:
(1996): Merlob P+, Cutis 57, 429 (n
Page 328 and 329:
Hair Hair - alopecia (>2%) Nails Na
Page 330 and 331:
GLYBURIDE Synonyms: glibenclamide;
Page 332 and 333:
(1982): Bailin PL+, Clin Rheum Dis
Page 334 and 335:
Acne (1996): Lee PK+, JAmAcadDermat
Page 336 and 337: (2006): Bonkovsky HL, AnnInternMed1
Page 338 and 339: Peripheral edema (>10%) Purpura Urt
Page 340 and 341: (1984): Binder RL+, J Clin Psychiat
Page 342 and 343: HEPARIN Trade names: Calcilean; Cal
Page 344 and 345: (1990): Rogerson SJ+, BMJ 301, 345
Page 346 and 347: (1991): Vitris M+, Dakar Med 36(1),
Page 348 and 349: Other Anaphylactoid reactions/Anaph
Page 350 and 351: Exanthems Exfoliative dermatitis Fi
Page 352 and 353: HYDROMORPHONE Trade names: Dilaudid
Page 354 and 355: (1994): Perrot JL+, Ann Dermatol Ve
Page 356 and 357: Edema (
Page 358 and 359: (1994): Halpern SM, Arch Dermatol 1
Page 360 and 361: Mucosal Oral lesions Sialorrhea (
Page 362 and 363: IMIGLUCERASE Trade name: Cerezyme (
Page 364 and 365: (2001): Fife KH+, Sex Transm Dis 28
Page 366 and 367: Herpes simplex (
Page 368 and 369: (2004): Scheinfeld N, J Drugs Derma
Page 370 and 371: (2000): Poole PJ+, Cochrane Databas
Page 372 and 373: Injection-site pain (2006): Moyes V
Page 374 and 375: (2002): Tothova E+, Neoplasma 49(2)
Page 376 and 377: (1995): Shinohara K, NEnglJMed333,
Page 378 and 379: IOPROMIDE Trade name: Ultravist (Be
Page 380 and 381: ISOCARBOXAZID Trade names: Enerzer;
Page 382 and 383: ISOSORBIDE Trade name: Ismotic Indi
Page 384 and 385: Nails Nails - brittle (2001): Önde
Page 388 and 389: (2001): Burstal R+, Anaesth Intensi
Page 390 and 391: Pruritus (1-10%) Psoriasis (1992):
Page 392 and 393: LAMIVUDINE Synonym: 3TC Trade names
Page 394 and 395: (2006): Fix OK+, Clin Gastroenterol
Page 396 and 397: Eyelashes - ptosis (2005): Casson R
Page 398 and 399: LETROZOLE Trade name: Femara (Novar
Page 400 and 401: Other Abdominal pain (2003): Cramer
Page 402 and 403: Photosensitivity (
Page 404 and 405: (2002): Kalin JR+, JForensicSci47(5
Page 406 and 407: (2002): Serratrice J+, Am J Ophthal
Page 408 and 409: (1981): Hess EV, Arthritis Rheum 24
Page 410 and 411: Purpura (
Page 412 and 413: Reactions Skin Angioedema (
Page 414 and 415: Other Abdominal pain (7%) Cough (1%
Page 416 and 417: Reactions Skin Acne (1998): Wollina
Page 418 and 419: (1983): Nusbaum BP+, Arch Dermatol
Page 420 and 421: (1997): O’Reilly FM+, American Ac
Page 422 and 423: MEMANTINE Trade names: Akatinol; Ax
Page 424 and 425: MERCAPTOPURINE Synonyms: 6-mercapto
Page 426 and 427: (1998): Leal G, Fortaleza, Brazil (
Page 428 and 429: (2002): Caplehorn JR+, Aust N Z J P
Page 430 and 431: (1995): Vogt T+, Br J Dermatol 133,
Page 432 and 433: Mucosal Aphthous stomatitis (2003):
Page 434 and 435: (1987): Norris PG+, Clin Exp Dermat
Page 436 and 437:
(1998): Corazza M+, Contact Dermati
Page 438 and 439:
METOCLOPRAMIDE Trade names: Apo-Met
Page 440 and 441:
Oral ulceration Stomatitis (1987):
Page 442 and 443:
Reactions Skin Erythema multiforme
Page 444 and 445:
(1996): Carrington PR, Little Rock,
Page 446 and 447:
(2003): Abe M+, Intern Med 42(1), 4
Page 448 and 449:
Other Abdominal pain (2006): Preutt
Page 450 and 451:
Erythema multiforme Exanthems (9-16
Page 452 and 453:
Page 454 and 455:
MUPIROCIN* Trade names: Bactoderm;
Page 456 and 457:
Mucosal Gingivitis (
Page 458 and 459:
(1981): Wolf A, ZHautkr(German) 56,
Page 460 and 461:
(1984): Stern RS+, JAMA 252, 1433 V
Page 462 and 463:
Hair Hair - alopecia (
Page 464 and 465:
NEVIRAPINE Trade name: Viramune (Bo
Page 466 and 467:
(1982): Grunwald Z, Drug Intell Cli
Page 468 and 469:
Urticaria (
Page 470 and 471:
(2000): Rodrigues de Oliveira J+, G
Page 472 and 473:
(2007): Koulaouzidis A+, Ann Hepato
Page 474 and 475:
Vulvovaginal candidiasis (2002): Me
Page 476 and 477:
Mucosal Oral mucosal eruption (1987
Page 478 and 479:
Mucosal Tongue edema Other Anaphyla
Page 480 and 481:
Chills (5-10%) Hypersensitivity (
Page 482 and 483:
OXACILLIN Trade names: Bactocill; B
Page 484 and 485:
Page 486 and 487:
OXYMORPHONE Synonym: 14-hydroxy-dih
Page 488 and 489:
(2001): Robinson JB+, Gynecol Oncol
Page 490 and 491:
PANCRELIPASE Trade names: Cotazym (
Page 492 and 493:
Exanthems Fixed eruption (1994): Ki
Page 494 and 495:
(2006): Bettoli V+, Acta Derm Vener
Page 496 and 497:
Reactions Skin Adverse effects (sic
Page 498 and 499:
(1981): Hashimoto K+, JAmAcadDermat
Page 500 and 501:
Hypersensitivity (1999): Hsu HL+, T
Page 502 and 503:
Injection-site calcification (1991)
Page 504 and 505:
PEPPERMINT Scientific name: Mentha
Page 506 and 507:
(1995): Magro CM+, JAmAcadDermatol3
Page 508 and 509:
(1993): Leenutaphong V+, Int J Derm
Page 510 and 511:
PHENYLEPHRINE Trade names: Dionephr
Page 512 and 513:
(1991): Kleier RS, Arch Dermatol 12
Page 514 and 515:
Lymphoproliferative disease (1992):
Page 516 and 517:
(2006): Andersen KE+, Contact Derma
Page 518 and 519:
Oral candidiasis Stomatodynia Vagin
Page 520 and 521:
Reactions Skin Exanthems Petechiae
Page 522 and 523:
Reactions Skin Acne (1-10%) Angioed
Page 524 and 525:
Pruritus (
Page 526 and 527:
PREDNISONE Trade names: Deltasone (
Page 528 and 529:
Other Anticonvulsant hypersensitivi
Page 530 and 531:
Xerosis Mucosal Lip ulceration (198
Page 532 and 533:
(1982): Gall H+, Derm Beruf Umwelt
Page 534 and 535:
(2006): Barkin RL+, Am J Ther 13(6)
Page 536 and 537:
PROTAMINE SULFATE Indications: Hepa
Page 538 and 539:
(1987): Shelley WB+, JAmAcadDermato
Page 540 and 541:
Hypersensitivity Myalgia/Myositis/M
Page 542 and 543:
(1999): Drayton G, Los Angeles, CA
Page 544 and 545:
(1986): Bigby M+, JAMA 256, 3358 (1
Page 546 and 547:
Nails Nails - photo-onycholysis (19
Page 548 and 549:
Hair Hair - alopecia (1-10%) Other
Page 550 and 551:
RASBURICASE Trade names: Elitek (Sa
Page 552 and 553:
RETEPLASE Synonyms: recombinant pla
Page 554 and 555:
Other Inappropriate secretion of an
Page 556 and 557:
Tongue pigmentation Vulvovaginal ca
Page 558 and 559:
Reactions Skin Acne (
Page 560 and 561:
RIZATRIPTAN Synonym: MK462 Trade na
Page 562 and 563:
Glossitis (1%) Stomatitis (
Page 564 and 565:
(1995): Brandstatter G+, Clin Ther
Page 566 and 567:
Mucosal Cheilitis (
Page 568 and 569:
SELENIUM Trade names: Bio-Active Se
Page 570 and 571:
Mucosal Aphthous stomatitis (
Page 572 and 573:
(2004): Vasconcelos OM+, Muscle Ner
Page 574 and 575:
(2005): Mahe E+, Transplantation 79
Page 576 and 577:
SOLIFENACIN Trade name: Vesicare (G
Page 578 and 579:
Urticaria (
Page 580 and 581:
Pruritus (1997): Golsch S+, Hautarz
Page 582 and 583:
Glossitis (2%) Oral mucosal eruptio
Page 584 and 585:
Reactions Skin Allergic reactions (
Page 586 and 587:
(1995): Hertl M+, Br J Dermatol 132
Page 588 and 589:
(1992): Bodokh I+, Presse Med (Fren
Page 590 and 591:
SULFISOXAZOLE* Trade names: Isoxazi
Page 592 and 593:
(1984): Stern RS+, JAMA 252, 1433 J
Page 594 and 595:
TACROLIMUS Synonym: FK506 Trade nam
Page 596 and 597:
(2005): Fumal I+, Dermatology 210(3
Page 598 and 599:
(2000): Ernst E+, Forsch Komplement
Page 600 and 601:
Page 602 and 603:
Reactions Skin Diaphoresis (>1%) Ed
Page 604 and 605:
Mucosal Oral ulceration (1987): Hig
Page 606 and 607:
TETRACYCLINE Trade names: Apo-Tetra
Page 608 and 609:
Xerosis (2002): Bariol C+, J Gastro
Page 610 and 611:
Eyes Conjunctivitis (allergic conta
Page 612 and 613:
Page 614 and 615:
(2000): Chemnitz JM+, Med Klin (Ger
Page 616 and 617:
Note: Cutaneous side-effects of bet
Page 618 and 619:
Other Cough (0.8%) Fever (4.6%) Hep
Page 620 and 621:
TOLAZAMIDE* Trade names: Diabewas;
Page 622 and 623:
Reactions Skin Erythema (1.9%) Fung
Page 624 and 625:
TOSITUMOMAB & IODINE 131 Trade name
Page 626 and 627:
(2001): Vogel CL+, Oncology 61, 37
Page 628 and 629:
(1997): Gilchrest BA, JAmAcadDermat
Page 630 and 631:
Erythema (1999): Alexiou C+, Laryng
Page 632 and 633:
*Note: Trichlormethiazide is a sulf
Page 634 and 635:
TRIMETHOPRIM* Trade names: Abaprim;
Page 636 and 637:
Myalgia/Myositis/Myopathy/Myotoxici
Page 638 and 639:
Other Death (2002): Avarello TP+, N
Page 640 and 641:
(2001): Pechlaner C+, Blood Coagul
Page 642 and 643:
Bullous dermatitis (2001): Christ E
Page 644 and 645:
(1985): Schifter S+, Lancet 2, 499
Page 646 and 647:
Page 648 and 649:
VERAPAMIL Trade names: APO-Verap; A
Page 650 and 651:
Mucosal Gingival hyperplasia/hypert
Page 652 and 653:
(2001): Laack E+, Ann Oncol 12(12),
Page 654 and 655:
Fixed eruption (
Page 656 and 657:
(1986): Sjoberg A+, Lakartidningen
Page 658 and 659:
(1990): Broder S+, Am J Med 88, 31S
Page 660 and 661:
(1989): Valencia ME+, Rev Clin Esp
Page 662 and 663:
ZOLPIDEM Trade names: Ambien (Sanof
Page 664 and 665:
DRUGS RESPONSIBLE FOR COMMON REACTI
Page 666 and 667:
Ethambutol Ethanolamine Etoposide F
Page 668 and 669:
Procarbazine Progestins Promethazin
Page 670 and 671:
Erlotinib Ertapenem Escitalopram Et
Page 672 and 673:
Feverfew Floxuridine Fluconazole Fl
Page 674 and 675:
Insulin glulisine Interferon alfa I
Page 676 and 677:
Acamprosate Acebutolol Acetaminophe
Page 678 and 679:
Amobarbital Amoxicillin Amphoterici
Page 680 and 681:
Spironolactone Streptomycin Sulface
Page 682 and 683:
Miconazole Midazolam Minocycline Mi
Page 684 and 685:
Heroin Hydralazine Hydrochlorothiaz
Page 686 and 687:
Nefazodone Nevirapine Niacin Nicoti
Page 688 and 689:
Mephenytoin Mercaptopurine Mesalami
Page 690 and 691:
Cephradine Cetuximab Chamomile Chlo
Page 692 and 693:
Oxaprozin Penicillin G Phenytoin Pi
Page 694 and 695:
Ritonavir Rofecoxib Saquinavir Sele
Page 696 and 697:
Chlorotrianisene Chlorpheniramine C
Page 698 and 699:
Timolol Tinidazole Tolcapone Topira
Page 700 and 701:
Maprotiline Marihuana Mebendazole M
Page 702 and 703:
Allopurinol Alprazolam Alteplase Am
Page 704 and 705:
Azatadine Azathioprine Azithromycin
Page 706 and 707:
Phenelzine Phenindamine Phenobarbit
Page 708 and 709:
Seborrheic Dermatitis Buspirone Chl
Page 710 and 711:
Dacarbazine Dactinomycin Daptomycin
Page 712 and 713:
Anagrelide Anidulafungin Anisindion
Page 714 and 715:
Rifampin Rifapentine Rifaximin Rise
Page 716 and 717:
Tretinoin Valdecoxib Varicella vacc
Page 718:
Prazosin Pregabalin Procarbazine Pr
Page 721 and 722:
646 DESCRIPTION OF THE 34 MOST COMM
Page 723 and 724:
Page 725 and 726:
Page 728 and 729:
ALPHABETICAL INDEX Abacavir 1 Abare
Page 730 and 731:
Hawthorn (fruit, leaf, flower extra
Page 732 and 733:
Tirofiban 543 Tixocortol 543 Tizani
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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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