Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Serum sickness
(1998): Park H+, Ann Pharmacother 32, 1249
IVERMECTIN
Trade name: Stromectol (Merck)
Indications: Various infections caused by susceptible helmintic
organisms
Category: Antihelmintic
Half-life: 16–35 hours
Clinically important, potentially hazardous interactions
with: alprazolam, barbiturates, benzodiazepines, diazepam,
midazolam, valproic acid
Reactions
Skin
Angioedema
(2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with
praziquantel and albendazole)
Bullous dermatitis
(1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313
Bullous pemphigoid
(2001): Trindade P, Natal, Brazil (personal communication)
Burning
(1999): Editorial, Arch Dermatol 135, 705
Dermatitis
(1999): Editorial, Arch Dermatol 135, 705
Edema (10–53%)
(1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143
(1995): Darge K+, Trop Med Parasitol 46, 206 (arms and legs)
(10%)
(1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313
(1992): Chijioke CP+, Trans R Soc Trop Med Hyg 86, 284
(1992): Collins RC+, Am J Trop Med Hyg 47, 156 (facial) (31.8%)
(1992): Zea-Flores R+, Trans R Soc Trop Med Hyg 86, 663 (53%)
(1991): Bryan RT+, Lancet 337, 304
(1991): Guderian RH+, Lancet 337, 188 (leg)
Exanthems (1–34%)
(1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313
(1991): Whitworth JAG+, Lancet 337, 625 (1–5%)
(1990): Ette EI+, Drug Intell Clin Pharm 24, 426 (34%)
Facial edema (1.2%)
(1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143
(1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313
Peripheral edema
Pruritus (38%–71%)
(2005): Nontasut P+, Southeast Asian J Trop Med Public Health
36(2), 442
(1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143
(1995): Darge K+, Trop Med Parasitol 46, 206
(1993): Burnham GM, Trans R Soc Trop Med Hyg 87, 313
(1993): Kar SK+, Acta Trop 55, 21
(1992): Chijioke CP+, Trans R Soc Trop Med Hyg 86, 284
(71.2%)
(1992): Collins RC+, Am J Trop Med Hyg 47, 156 (34%)
(1991): Bryan RT+, Lancet 337, 304
(1991): Whitworth JAG+, Lancet 337, 625 (8%)
(1990): Ette EI+, Drug Intell Clin Pharm 24, 426 (9.6%)
(1989): Guderian RH+, Eur J Epidemiol 5, 294 (4%)
Pustules
Rash (sic) (1–93%)
(1998): Jaramillo-Ayerbe F+, Arch Dermatol 134, 143
(1993): Kar SK+, Acta Trop 55, 21
(1991): Bryan RT+, Lancet 337, 304 (93%)
(1991): Guderian RH+, Lancet 337, 188
(1991): Whitworth JAG+, Lancet 337, 625 (8%)
(1989): Guderian RH+, Eur J Epidemiol 5, 294 (4%)
Side effects (sic) (mild)
(2002): Prescrire Int 11(61), 137
Urticaria (0.9–22.7%)
(2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with
praziquantel and albendazole)
Other
Abdominal pain
(2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with
praziquantel and albendazole)
Fever
(2006): Olson BG+, Pediatr Infect Dis J 25(5), 466 (with
praziquantel and albendazole)
(2004): Pani SP+, JCommunDis36(4), 240
Myalgia/Myositis/Myopathy/Myotoxicity (20%)
(2004): Pani SP+, JCommunDis36(4), 240
(1995): Darge K+, Trop Med Parasitol 46, 206 (20%)
(1993): Kar SK+, Acta Trop 55, 21
JOJOBA OIL
Scientific names: Buxus chinensis; Simmondsia chinensis
Family: Simmondsiaceae
Trade and other common names: Coffeebush; Deer-nut;
Goat-nut; Pig-nut
Purported indications and other uses: Moisturizer in
cosmetics and hair care products, edible oil
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
Reactions
Skin
Dermatitis
(2006): Di Berardino+, Contact Dermatitis 55(1), 57
(1996): Wantke F+, Contact Dermatitis 34(1), 71
JUNIPER
Scientific names: Juniperus communis; Juniperus oxycedrus;
Juniperus phoenicea; Juniperus virginiana
Family: Cupressaceae
Trade and other common names: Baccae Juniperi; Cade Oil;
Enebro; Gemeiner Wachholder; Genevrier; Ginepro; Juniper Tar
Oil; Zimbro
Category: Anti-inflammatory
Purported indications and other uses: Cystitis, urethritis,
urinary tract infections, flatulent colic, rheumatism, arthritis, gout,
leucorrhea, blenorrhea, scrofula. Topical: joint pain, muscle pain,
neuralgia, chronic eczema. Inhalant: bronchitis, lung infections.
Condiment, flavor component (gin, Chartreuse, bitters), perfume
Half-life: N/A
Clinically important, potentially hazardous interactions
with: loop diuretics, spironolactone, thiazide diuretics,
triamterene
Skin
Allergic reactions (sic)
Reactions
JUNIPER 311