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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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310 ITRACONAZOLE<br />

ITRACONAZOLE<br />

Trade names: Isox; Itranax; Sopronox; Sporacid; Sporal;<br />

Sporanox (Janssen) (Ortho); Sporanox 15 D<br />

Indications: Onychomycosis, deep mycoses<br />

Category: Antibiotic, triazole<br />

Half-life: 21 hours<br />

Clinically important, potentially hazardous interactions<br />

with: alfuzosin, alprazolam, amphotericin B, anisindione, antacids,<br />

aprepitant, atorvastatin, bosentan, cimetidine, clorazepate,<br />

conivaptan, dasatinib, dexamethasone, dicumarol, didanosine,<br />

eplerenone, erythromycin, ethotoin, fentanyl, fosamprenavir,<br />

fosphenytoin, grapefruit juice, HMG-CoA reductase inhibitors,<br />

imatinib, lapatinib, lovastatin, mephenytoin, methylprednisolone,<br />

midazolam, pimozide, prednisolone, prednisone, quinidine,<br />

rifampin, rimonabant, sildenafil, simvastatin, sirolimus, solifenacin,<br />

temsirolimus, terfenadine, triazolam, vardenafil, vinblastine,<br />

vincristine, warfarin<br />

Reactions<br />

Skin<br />

Acute generalized exanthematous pustulosis (AGEP)<br />

(1997): Park YM+, JAmAcadDermatol36, 794<br />

(1995): Heymann WR+, JAmAcadDermatol33, 130<br />

Angioedema<br />

(1996): Foong H, Malaysia (from Internet) (observation)<br />

Edema (

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