Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

ISOCARBOXAZID
Trade names: Enerzer; Marplan (Oxford)
Indications: Depression
Category: Antidepressant; Monoamine oxidase (MAO) inhibitor
Half-life: N/A
Clinically important, potentially hazardous interactions
with: amitriptyline, amoxapine, bupropion, citalopram,
clomipramine, desipramine, doxepin, fluoxetine, fluvoxamine,
imipramine, meperidine, nefazodone, nortriptyline, paroxetine,
protriptyline, rizatriptan, sertraline, sibutramine, sumatriptan,
trimipramine, tryptophan, venlafaxine, zolmitriptan
Reactions
Skin
Diaphoresis
Exanthems (7%)
Peripheral edema (1–10%)
Photosensitivity (4%)
Pruritus (4%)
Rash (sic)
Telangiectasia
Mucosal
Tongue black
Xerostomia (1–10%)
(1984): Zisook S, J Clin Psychiatry 45(7 Pt 2), 53
ISOETHARINE
Trade names: Arm-a-Med; Asthmalitan; Beta-2; Bronkomed;
Dey-Lute; Numotac
Indications: Bronchial asthma
Category: Adrenergic beta-receptor agonist
Half-life: N/A
Clinically important, potentially hazardous interactions
with: phenelzine
Reactions
Mucosal
Xerostomia (1–10%)
Other
Anaphylactoid reactions/Anaphylaxis
(1982): Twarog FJ+, JAMA 248, 2030
ISOFLURANE
Trade names: Aerrane; Floran; Forane (Baxter); Forene;
Forthane; Isofluran; Isoflurano; Isofor; Isorane; Lisorane; Sofloran;
Tensocold
Indications: Maintenance of general anesthesia
Category: Anesthetic, inhalation
Half-life: N/A
Onset of action: 7–10 minutes
Clinically important, potentially hazardous interactions
with: cisatracurium, doxacurium, muscle relaxants, pancuronium,
rapacuronium
Reactions
Skin
Shivering (post-operative)
Other
Death
(2006): Ihtiyar E+, Indian J Gastroenterol 25(1), 41
ISONIAZID
Synonym: INH
Trade names: Cemidon; Diazid; Isotamine; Isozid; Nicotibine;
Nicozid; PMS-Isoniazid; Rifamate (Sanofi-Aventis); Rifater (Sanofi-
Aventis); Tibinide
Indications: Tuberculosis
Category: Antibiotic; Antimycobacterial
Half-life: 1–4 hours
Clinically important, potentially hazardous interactions
with: insulin detemir, rifampin
Reactions
ISONIAZID 305
Skin
Acne
(1988): Oliwiecki S+, Clin Exp Dermatol 13, 283
(1988): Yamanaka M+, Kekkaku (Japanese) 63, 11
(1982): Rosin MA+, Southern Med J 75, 81 (passim)
Acute generalized exanthematous pustulosis (AGEP)
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
Angioedema (